What is the cause of premature decay of body cells?

The most likely cause is malnutrition, and supplementing with some necessary nutrients may alleviate it. Another reason is that there is a genetic disease, so it is recommended to go to the hospital for examination.

1. Excessive macromolecular cross-linking is a major factor of aging, such as DNA cross-linking and collagen glue can damage their function and cause aging.

2. After the accumulation of cell metabolites to a certain amount, it will harm the cells and lead to the aging of the cells.

3. Free radicals contain unpaired electrons, which are highly reactive, which can trigger chain self-slag rotten radical reactions, such as denaturation and cross-linking of DNA, proteins and lipids, especially polyunsaturated fatty acids and other macromolecular substances, damaging DNA, biofilms and structural proteins and functional proteins, thereby causing the occurrence of various phenomena of aging.

4. The mitochondria that exist in the cells to provide energy are prone to mutations, and the accumulation of mutations is likely to be one of the reasons for the aging of the human body.

The phenomenon that occurs in the nucleus of senescent cells is called swelling of the nucleus.

This question involves a lot of senescent cell changes, and the main ones are as follows:

1.As a result of cellular senescence, transcriptional capacity decreases, histone proteins decrease, and chromatin condensation decreases, affecting the transcription of related proteins.

2.The composition of the nuclear skeleton changes, the nuclear fiber layer has a supporting role in the nuclear membrane, and the cell aging causes the structure of the nuclear fiber layer to loosen, and the supporting role of the nuclear layer is reduced.

3.Alteration of ion concentration: due to cell aging, the stability of the nuclear pore complex and nuclear membrane decreases and permeability increases. The extremely strict difference in the concentration of ions inside and outside the nucleus affects the tension of the membrane and the concentration and amount of the internal nuclear matrix, resulting in the swelling of the nucleus.

Studies have shown that the nucleus, cytoplasm and cell membrane of senescent cells have obvious changes: the intracellular water decreases, the volume becomes smaller, and the metabolism slows down; decreased activity of intracellular enzymes; Pigments accumulate within the cells; Intracellular respiration slows down, the nucleus increases in size, the nuclear membrane folds inward, chromatin shrinks, and the color darkens. The number of mitochondria decreases and the volume increases; The permeability function of the cell membrane is changed, which reduces the function of material transport.

Morphological changes In general, the various structures of aging cells are degenerating.

The process of cellular senescence is a process of complex physiological and biochemical changes in cells, which is ultimately reflected in changes in the morphology, structure and function of cells, so it has the main characteristics of cellular senescence: (1) The water in senescent cells decreases, resulting in cell atrophy, smaller volume, and slowed down cell metabolism. (2) In senescent cells, the activity of some enzymes decreases.

For example, when melanocytes at the base of a person's hair age, tyrosinase activity in the cells decreases, which can lead to graying of the hair. (3) Intracellular pigments will gradually accumulate with cell aging. Due to the increase in the area occupied by lipofuscin in cells, it hinders the communication of intracellular substances and the transmission of information, affects the normal physiological functions of cells, and finally leads to cell aging and death.

4) The rate of intracellular respiration in senescence slows down, the volume of the nucleus increases, and the chromatin consolidates and the staining deepens. (5) The permeability function of the cell membrane is changed, which reduces the material transport function.

It comes down to the results of metabolism.

Because human cells need 30 to 50 different colors and different tastes of nutrients every day to nourish, if we only rely on daily meals can not be solved, then there will be cells in a state of hunger for many years, cells are hungry, tissues, organ functions begin to decline, then the system will not be smooth, the whole person will age, all kinds of diseases will follow, if you want to solve the problem to follow these steps, 1, balanced nutrition 2, good attitude 3, adequate sleep 4, appropriate exercise, These four cornerstones are indispensable and cannot be substituted for each other.