Explain the main causes of myasthenia gravis from the perspective of cell membrane material transpor

1. Familial hereditary: In recent years, many autoimmune diseases have been observed and found that they are not only related to often histocompatibility antigen complex genes but also incompatible antigen complex genes, such as T cell receptor and immunoglobulin, cytokines, apoptosis and other genes, which is one of the myasthenia gravis.

2. Abnormal immune system: clinical observation found that many immune indicators in patients with myasthenia gravis are abnormal, and the clinical symptoms disappear after diagnosis and treatment, but the abnormal immune indicators do not change, which may be an important factor in the instability of myasthenia gravis and easy to attack, which is the cause of myasthenia gravis.

3. External environmental factors: myasthenia gravis is caused by environmental pollution that can bring about a decline in the immune system, overwork that causes immune dysfunction in the body, viral infection or the use of certain antibiotics and drugs by patients to induce certain genetic defects.

4. Mental factors, the cause of myasthenia gravis is excessive fatigue because of playing mahjong and computer games for a long time, on the one hand, it can reduce the body's defense function and induce respiratory tract infections, and on the other hand, excessive fatigue aggravates the weakness of respiratory muscles and swallowing muscles, inducing crises. To this end, it is necessary to combine work and rest, maintain a comfortable mood, and do a good job in preventing myasthenia gravis.

5. Psychologically, many patients suffer from this disease, which damages their emotional marriage, thus losing emotional support, weakening their confidence in overcoming the disease, and inducing crisis awareness.

Liu Quanpeng, Deputy Chief Physician of the Department of Impotence, Beijing Deshengmen Hospital of Traditional Chinese Medicine What are the causes of myasthenia gravis?

It still has a lot to do with it.

Liu Quanpeng, deputy chief physician of the Department of Impotence of Beijing Deshengmen Hospital of Traditional Chinese Medicine, made the muscle gravis or the cause of the weakness of the rapid bureau Chang Nian.

The structure of the nerve endings in contact with the muscle cells is called the neuro-muscular junction, which resembles a synapse, and the membrane of the axon endings is called the anterior junction membrane, which is filled with a vesicle encapsulated acetylcholine address, waiting to be distributed. The gap in the middle is called the junction space, which is similar to the synaptic cleft, and there is nothing to explain it. The opposite muscle membrane is called the posterior membrane of the joint, which is professionally called the end plate, and the endplate is distributed with the receptor of acetylcholine, which is used to feel the acetylcholine released by the anterior membrane and cause subsequent muscle excitement.

Myasthenia gravis is an autoimmune disease in which the immune system produces antibodies that bind to the endplate membrane acetylcholine receptors, resulting in the inability to feel the anterior membrane ACH and causing the muscles to relax and not contract.

Myasthenia gravis (MG) is an autoimmune disease caused by dysfunction of transmission at the neuromuscular junction, which is clinically manifested as partial or systemic skeletal muscle weakness and fatigue, which worsens after activity and is relieved by rest. The prevalence is 77,150,100,000, with an annual incidence of 4,111,100 million. The prevalence is greater in women than in men, about 3:

2. It occurs in all ages, and children are mostly 1 to 5 years old.

Clinical presentation. In the early stages of myasthenia gravis, patients often feel soreness and discomfort in the eyes or limbs, or blurred vision, fatigue is easily fatigued, and fatigue is worse in hot weather or menstruation. As the disease progresses, skeletal muscles become significantly fatigued and weak, which is characterized by muscle weakness that worsens after exertion in the afternoon or evening and decreases after getting up or resting, a phenomenon called "morning light and twilight heaviness".

1.Patients with myasthenia gravis can have skeletal muscle involvement throughout the body and may have the following symptoms.

1) Dropy eyelids, blurred vision, diplopia, strabismus, and inflexible eye movement.

2) Indifferent expression, wry smile, large tongue, difficulty in arthria, often accompanied by nasal voice.

3) Weakness in chewing, choking on drinking water, and difficulty swallowing.

4) Weak neck, difficulty in raising the head, weakness in turning the neck and shrugging the shoulders.

5) Difficulty in raising arms, combing hair, going up stairs, squatting, and getting on the bus.

Liu Quanpeng, deputy chief physician of the Department of Impotence of Beijing Deshengmen Hospital of Traditional Chinese Medicine, made the muscle gravis or the cause of the weakness of the rapid bureau Chang Nian.