Does cell differentiation have to be irreversible, and what does it mean that cell differentiation i

Cell differentiation is irreversible, which means that in the organism there is a problem but it is said to be reversible, which refers to in the ex vivo condition.

The totipotent type of cells is an ex vivo condition, and it is true to say that the future of cell differentiation is determined and irreversible in the early stages of embryonic reproduction, but highly differentiated animal cells.

It can't be reversed.

Schematic diagram of cell differentiation In ontogeny, the process by which the progeny of one or one type of cells proliferates and changes in stability in morphological structure and physiological function is called cellular differentiation. Cell differentiation is a persistent change that occurs not only during embryonic development, but also throughout life to replenish aging and dying cells For example, the process of cell differentiation of pluripotent hematopoietic stem cells into different blood cells.

In general, differentiated cells will remain in their differentiated state until they die.

Therefore, it is irreversible, at least from the perspective of scientific experiments at this stage.

No, at least plant cells can be reversed, but highly differentiated animal cells cannot, and less differentiated animal cells can still be reversed.

Highly differentiated plant cells can be reversed in vitro!

Explants (ex vivo plant tissues, organs, or cells) – dedifferentiation (dedifferentiation) – callus ——— redifferentiation ———

It can be reversed, and there is no direct evidence to prove it, but theoretically it can.

Not necessarily, for example, the process of plant tissue culture is the process of reversing the differentiation and then re-differentiating of cells, you can look up this information on the Internet, there are many of them.

No, it is possible under certain conditions. For example, tissue culture of plant cells results in the formation of callus, which is a reversal. I think I've heard that tumor cells also fall into this category, but I'm not sure about that.

There are two ways to do this:

1.Isolated cells can be reversed, such as plant tissue culture, provided that the tissue or cell is isolated from the body.

2.The differentiation of cells that are not in vitro cannot be reversed.

It can be reversed, such as the dedifferentiation of plants.

The irreversibility of cell differentiation refers to the fact that once the cell differentiates in an organism, it will develop in a specific direction, that is, the cell has the specificity of cracking. For example, kidney cells, liver cells.

**Epidermal cells, etc., are cells with a single function after differentiation. These cells can only perform their own unique functions and then age and die.

Cells that have evolved to functionally differentiate cannot become cells with other functions again, such as kidney cells can only constitute kidneys and have the functions of kidney cells, and can no longer differentiate or transform into liver cells or ** cells. The root cells of the vast majority of plants also do not produce green leaves. This is the irreversibility of cell differentiation.

The rejuvenation of human cells is not a dream.

Chinese scholars have discovered the phenomenon of reverse differentiation of epidermal cells.

Can human cells be rejuvenated? In the recently published international famous medical journal "The Lancet", Professor Fu Xiaobing, a young trauma surgeon in China and director of the Trauma Surgery Research Office of the 304 Hospital of the People's Liberation Army, published the academic "Clinical Research on the Transformation of Epidermal Cells from Reverse Differentiation into Epidermal Stem Cells", which took the lead in reporting the phenomenon of reverse differentiation of human epidermal cells in the world.

Epithelial cells are one of the most metabolically active and vulnerable organs in the human body. Since the mid-nineties of the 20th century, under the guidance of Sheng Zhiyong, Wang Zhengguo, and other academicians who are famous in China's wound burn surgery experts, Professor Fu Xiaobing and his research group have first observed clinical phenomena that cannot be explained by traditional repair theories in the molecular and genetic mechanisms of wound healing and tissue regeneration, such as why wounds can be quickly repaired under the action of very small growth factors; I used to use growth factors, why can some epidermis change from "old" to "tender".

In order to reveal this mystery, Fu Xiaobing et al. began to explore the regulatory relationship between growth factors and stem cells. Through a large number of histological sections and a series of identification studies from developmental, histological and methodological studies, it was found that there was a phenomenon of stem cell aggregation in the wound healed with epidermal cell growth factor** (this phenomenon has been named "stem cell island phenomenon" by Fu Xiaobing), and it has been preliminarily proved that the stem cells existing in the repair epidermal spinous cells and granulosa cells are induced by epidermal cell growth factor, which is the result of the reverse differentiation of differentiated epidermal cells into epidermal stem cells. The discovery and preliminary confirmation of the phenomenon of reverse differentiation of epidermal cells provides a theoretical basis for the long-term pursuit of "rejuvenation" of tissue cells.

It is not only an important discovery in cell biology, but also has important implications for the in-depth elucidation of wound repair mechanisms. At the same time, this special phenomenon of reversing from differentiated epidermal cells to epidermal stem cells also has potential significance, such as the use of residual epidermal stem cells to regenerate sweat glands and hair follicles, and some refractory diseases.

After this important discovery was published in The Lancet, it caused strong repercussions at home and abroad. **On the day of the publication, Reuters sent an email to do a special interview, and more than 10 professors from France, the United States, and Israel also called to hope for in-depth research. The commendability of this discovery lies in the fact that it is a difficult basic research carried out by Fu Xiaobing and his domestic counterparts, and it is also the second important academic article published by Fu Xiaobing in The Lancet since 1998.