What is the chemical raw material of methyl violet solution,

1 Pinyin 2 English references.

3 Pharmacopoeia standards for methyl violet solution.

Product name: Chinese name: Hanyu Pinyin.

English name content or potency provisions.

Determination of the content of the identification of prescription production traits.

Category: Storage version attached: *Methyl violet solution drug instructions.

jiǎ zǐ róng yè

methylrosanilinium chloride solution

Chinese name: methyl violet solution.

Hanyu Pinyin jiazi rongye

English name: methylrosanilinium chloride solution

This product contains methyl violet should be % g ml).

10g of purple stuffy jujube xun, an appropriate amount of ethanol, and an appropriate amount of water are made into 1000ml

Take methyl violet, add an appropriate amount of ethanol to dissolve, and then add an appropriate amount of water to make 1000ml, filter, that is, to get this.

This product is a purple liquid.

1) take 5ml of this product, add 2 drops of hydrochloric acid, and add tannic acid test solution dropwise to generate a dark blue precipitate.

2) take 2ml of this product, evaporate it on a water bath, take a little residue, and sprinkle it on the liquid surface of 1ml of sulfuric acid, that is, it dissolves into an orange-yellow or brown-red solution, pay attention to dilute with water, that is, the rock talks become brown, gradually turn green, and finally turn blue.

The loading amount of this product shall be checked according to the minimum loading inspection method (Appendix F of Part II of the 2010 edition of the Pharmacopoeia), and shall comply with the regulations.

Take 10ml of this product accurately, put it in an evaporation dish of 105 constant weight, evaporate it on a water bath, dry it to constant weight at 105, calculate, and obtain.

Disinfectant antiseptics.

Shade and seal for preservation.

Methyl violet belongs to triphenylmethane dye disinfectant, and the microbial enzyme system has a competitive confrontation of hydrogen ions, so that the enzyme car delay into an inactive oxidation state, so as to play a bactericidal effect. It mainly has a killing effect on gram-positive bacteria such as staphylococcus baredo, diphtheria bacillus, as well as Pseudomonas aeruginosa, Candida albicans and epidermophyte, and has almost no effect on other gram-negative bacteria and acid-fast bacteria.

Indications: It is used for suppuration of ** and mucous membranes**, stomatitis caused by Candida albicans, and also for scalds, burns, etc.

Potential carcinogenicity.

American toxicologists have found that alpha violet is a dose-related carcinogen that can cause liver cancer, a certain adenoma and sarcoma in rodents, and in vitro cell tests have also confirmed that alphaviolet can cause mutagenesis and chromosomal breakage. However, the results of animal tests are based on long-term oral ingestion of methyl violet for up to 1 2 years. If it is used externally in a normal **, the dose is very low, and it is difficult for methyl violet to enter the human body.

Therefore, in European and American countries, it is strictly forbidden to mix with animal feed (methyl violet has the effect of controlling intestinal parasites), and it cannot be taken internally, but it is not completely forbidden to use it externally.

At present, there are no monitoring reports of adverse reactions caused by methyl violet carcinogenesis in China, and there are no such cases reported internationally. Although methyl violet solution is rarely used in current clinical practice, it is still used as a topical disinfectant in the drug list of various countries and the World Health Organization (WHO).

When using, in order to avoid the body's ingestion of alpha-violet solution, long-term, high-dose and large-scale use should be avoided.