Explanation of terminology in technical specifications for chemical toxicity identification

Adopted at the 52nd executive meeting on January 9, 2002, promulgated by Order No. 344 of the People's Republic of China on January 26, 2002, and effective as of March 15, 2002; According to the 144th executive meeting on February 16, 2011, it was revised and adopted, and re-promulgated on March 2, 2011 by Order No. 591 of the People's Republic of China, which came into force on December 1, 2011; According to the 32nd executive meeting of Hengpi on December 4, 2013, promulgated on December 7, 2013 by Order No. 645 of the People's Republic of China, and implemented on December 7, 2013, the "Decision on Amending Some Administrative Regulations" is amended).

Chapter I: General Provisions.

Article 1 These Regulations are formulated in order to strengthen the safety management of hazardous chemicals, prevent and reduce accidents with hazardous chemicals, ensure the safety of people's lives and property, and protect the environment.

Article 2 These Regulations shall apply to the safety management of the production, storage, use, operation and transportation of hazardous chemicals.

The disposal of discarded hazardous chemicals shall be carried out in accordance with the relevant laws, administrative regulations and relevant national regulations on environmental protection.

Article 3 The hazardous chemicals mentioned in these Regulations refer to highly toxic chemicals and other chemicals that are toxic, corrosive, combustible, combustion-aiding, etc., and are harmful to the human body, facilities and the environment.

The catalogue of hazardous chemicals shall be determined and published by the competent departments of production safety in conjunction with the competent departments of industry and information technology, public security, environmental protection, health, quality supervision, inspection and quarantine, transportation, railway, civil aviation, and agriculture according to the identification and classification standards of chemical hazard characteristics, and shall be adjusted in a timely manner.

Article 4 Safety management of hazardous chemicals shall adhere to safety first.

First, the policy of prevention first and comprehensive management, strengthen and implement the main responsibility of the enterprise.

The main person in charge of the unit that produces, stores, uses, operates and transports hazardous chemicals (hereinafter referred to as the hazardous chemicals unit) shall be fully responsible for the safety management of hazardous chemicals in the unit.

Hazardous chemicals units shall meet the safety conditions stipulated by laws and administrative regulations and national standards and industry standards, establish and improve safety management rules and regulations and post safety responsibility systems, and conduct safety education, legal education and on-the-job technical training for employees. Employees shall receive education and training, and work after passing the assessment; For positions that are qualified and required, personnel shall be assigned to obtain corresponding qualifications in accordance with law.

Article 5 No unit or individual shall produce, operate or use hazardous chemicals prohibited by the State.

Where the state has restrictive provisions on the use of hazardous chemicals, no unit or individual may use hazardous chemicals in violation of the restrictive provisions.

Acute dermal toxicity: the health damage effect of the tested sample after one or more times of exposure to the virus within 24 hours.

Dermal median lethal dose: the dose that causes the death of 50% of experimental animals by ** trembling and poisoning of the test sample Kuanbipin once or multiple times within 24 h, expressed as mg kg bw.

Dose-response relationship: Indicates the relationship between the dose of a chemical poison and the incidence of a mass effect in a population.

This specification is formulated in accordance with the Law of the People's Republic of China on the Prevention and Treatment of Occupational Diseases, the Regulations on the Labor Protection of the Use of Toxic Substances in the Workplace, the Regulations on the Safety Management of Hazardous Chemicals, the Measures for the Administration of Occupational Health Technical Service Institutions, and the Administrative Standards for the Identification of Chemical Toxicity.

This method specifies the basic principles, techniques and requirements for acute percutaneous toxicity testing in animals.

This method is suitable for the evaluation of acute percutaneous toxicity of chemicals.