Where is the regorafenib regofinib regofinib Chinese manual?

RegorafenibInstruction manual:

Main ingredient] regorafenib.

Properties】 40 mg film-coated tablets.

Indications Indications] Stivarga is a kinase inhibitor indicated for patients with metastatic colorectal cancer (CRC) who have previously received fluoropyrimidine-, oxaliplatin, and irinotecan-based chemotherapy, an anti-VEGF, and, as in the KRAS wild-type, an anti-EGFR.

Specification and model] 40mg*28s

Dosage] (1) Recommended dose: 160 mg orally, once a day for the first 21 days of a 28-day course of treatment. (2) Take stivarga (a low-fat breakfast) with food.

Adverse reactions] The most common adverse reactions (30%) were fatigue, decreased appetite and food intake, hand-foot** reaction (HFSR) [palmar foot redness and swelling (PPE)], diarrhea, oral mucositis, weight loss, infection, hypertension, and dysphonia.

Contraindications] are not clear.

Precautions】 (1) Bleeding: For severe or life-threatening bleeding, stivarga is permanently terminated. (2) ** Toxicity:

Regorafenib tablets** are discontinued and then reduced or discontinued with stivarga depending on the severity and persistence of the toxicity. (3) Hypertension: Temporary or permanent termination of stivarga for severe or uncontrollable hypertension.

4) Cardiac ischemia and infarction: Refusal to give stivarga to new or acute ischemic infarction and recovery only after resolution of acute ischemic events. (5) Reversible posterior leukoencephalopathy syndrome (RPLS):

Terminate stivarga. (6) Perforation or fistula of the gastrointestinal tract: terminate stivarga.

7) Complications of wound healing: regorafenib tablets ** are sold before surgery to stop stivarga. Terminated in wound dehiscence patients.

8) Embryonic fetal toxicity: may cause fetal harm. Advise women about potential risks to the fetus.

Storage] Shading, sealed storage.

Regorafenib is the only oral targeted drug for bowel cancer, and it has also passed the targeting of liver cancer**, several versions, the Bangladeshi version of 1,000 to 2,000, and the domestic one is now also under medical insurance, and it only takes 2ooo in my case