What is the effect of adenosylmethionine butyl disulfonate enteric coated tablets

Adenosylmethionine butadisulfonate can restore the fluidity of the cytoplasmic membrane by promoting the synthesis of adenosylmethionine-dependent membrane phospholipids (reducing the proportion of cholesterol phospholipids), overcome the transthio-reaction disorder, promote the synthesis of sulfur groups in the endogenous detoxification process and achieve the purpose of anti-cholestasis. Simeite, which can be used for intrahepatic cholestasis before cirrhosis and cirrhosis; **Intrahepatic cholestasis during pregnancy.

Adenosylmethionine succinate enteric-coated tablets can accelerate the resolution of jaundice, promote the recovery of liver function, reduce postoperative complications, significantly improve symptoms, effectively improve oxygen stress injury after biliary obstruction, and significantly improve liver function. At the same time, adenosylmethionine butyl disulfonate enteric-coated tablets (Simite) achieve a detoxification effect by promoting glutathione synthesis and neutralizing toxic substances.

As a methyl donor and a precursor of physiological sulfhydryl compounds, adenosylmethionine butyl tetraben enteric-coated tablets (SMITE) are involved in important biochemical reactions in vivo.

Adenosylmethionine is a physiologically active molecule ubiquitous in human tissues and fluids. It acts as a methyl donor, methyl action, and a precursor to physiological sulfhydryl compounds (such as cysteine, taurine, glutathione, and coenzyme A) and thio-group action, which participates in important biochemical reactions in vivo.

In the liver, adenosylmethionine regulates the fluidity of the liver cell membrane by methylating the plasma membrane phospholipids, and the synthesis of sulfide products during detoxification can be promoted through the transthio-group reaction. These reactions help prevent intrahepatic cholestasis.

The multiple mechanisms of action of adenosylmethionine are mainly reflected in the following aspects:

Methyl transgeny: improve the fluidity of liver cell membranes, enhance the activity of Na+-K+-ATPase, promote bile secretion and function, and participate in neurotransmitter synthesis, which can improve patients' mood.

Transthio: Generate endogenous antidotes, such as cysteine, glutathione, taurine, etc., to exert detoxification, antioxidant effects, and reduce liver cell damage.

Transpropylamine: synthesizes biopolyamines, participates in metabolism in the body, regulates the regeneration and proliferation of hepatocytes, and accelerates liver function repair.

Initial**: Use adenosylmethionine butadisulfonate for injection, 500-1000 mg per day, intramuscularly or intravenously, for a total of two weeks. The IV must be given very slowly.

Maintenance**: Use adenosylmethionine butyl disulfonate enteric-coated tablets, 1000-2000 mg per day, orally.

Its chemical name is:( 5'-[r[sup]*[sup])-r[sup]*[sup])-3-ammonia to likyl-3-carboxypropyl nuclear grinding late group]methylsulfonyl]-5'-Deoxyadenosine 1,4-butanedisulfonate, its structural formula is: Molecular Formula:

c15h23n6o5s[sup]+[sup] ·c4h9o6s2[sup]- sup]· Molecular weight:

Adenosylmethionine butyl disulfonate enteric-coated tablets are indicated for intrahepatic cholestasis before and after liver cirrhosis. It is indicated for intrahepatic cholestasis during pregnancy.