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Parkinson's disease (PD), also known as parkinsonism, is one of the most common neurodegenerative diseases. Epidemiology shows that the prevalence is 15,328,100,000 in the population, or about 1% > 65 years of age; The incidence is 10 21 100,000 population years. PD** and its pathogenesis are not yet clear, and may be related to social factors, drug factors, patient factors, etc.
The pathological changes of PD are: depigmentation of substantia nigra and coeruleus neurons in the midbrain, pale pigment of substantia nigra and the appearance of Lewy bodies. PD neurobiochemical changes to:
The loss of neurons in the substantia nigra and locus coeruleus in the midbrain leads to a decrease in dopamine (DA) in the above parts and their nerve endings, (PD clinical manifestations are produced when DA is reduced by 70%), while the acetylcholine (ACH) in the substantia nigra striatal system is relatively hyperactive, and the balance between DA and ACH is out of balance.
Clinical presentation. 1.Motor symptoms.
bradykinesia, muscle rigidity, resting tremor, postural gait abnormalities.
2.Non-motor symptoms.
Cognitive psychiatric abnormalities, sleep disturbances, autonomic dysfunction, sensory disturbances.
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Parkinson's is a degenerative disease of the nervous system, which is mainly manifested by poker face, resting tremor, bradykinesia, postural gait disorders, etc.
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A: It's Alzheimer's disease, such as Biden in the United States!
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Parkinson's disease is a progressive condition that worsens over time, and in the early stages, some symptoms tend to indicate Parkinson's disease, so early detection is better prepared.
Limb tremors: In the early stages of Parkinson's, these tremors are often subtle and may occur in subtle areas, such as a noticeable tremor in the fingers or in one limb. When at rest, these symptoms are more pronounced and are called resting tremor.
In the early stages, be sure to pay more attention.
Abnormal walking posture: Parkinson's is not only a simple case of shaking hands and feet, Parkinson's itself will affect the human motor nerves due to the decrease of dopamine substances, which will then cause some limb stiffness, which can develop from one place or one side to the whole body. Most patients with advanced Parkinson's disease have general stiffness and difficulty in taking care of themselves.
In the early stages, there is a stiffness in one part of the body, or an abnormal posture when walking due to the stiffness. Be sure to pay attention.
Sleep quality: Parkinson's can seriously affect the sleep quality of patients, and some patients will have symptoms such as sleepless nights, insomnia, dreaminess, and light sleep. In the early stages of the disease, Parkinson's can also have an impact on sleep quality.
In addition, in the early stage of Parkinson's there will be some characteristics, such as mask face, constipation, weakness of hands and feet, etc., the appearance of these symptoms does not mean that it is necessarily Parkinson's, but it is also necessary to pay more attention to and prevention, if a similar situation is found, we must go to the relevant examination in time.
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What is the pain of Parkinson's patients, Parkinson's patients will have numbness in the limbs at first, and then the body will gradually develop movement disorders, and finally there will be degenerative diseases, resulting in brain dementia.
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Parkinson's pain is as follows: skeletal muscle pain; radicular or neuropathic pain; dystonia-related pain; pain caused by not being able to sit still; peripheral or central Parkinson's disease pain, musculoskeletal pain, central pain, etc.
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What is the pain of Parkinson's patients, Parkinson's.
Patients will experience a variety of pain for life.
It has caused significant effects, such as muscle cramps.
Pain and joint pain, often accompanied by soreness, strong muscles.
Straight pain, with localized postural abnormalities, mobility.
After relieve, radiating sharp pain, often present.
Numbness and tingling in the fingers and toes are present and persistent.
Dull pain, tingling, burning, or tight banding.
Hoop sensation, sometimes with transient knife cuts or electric shocks.
Acute onset of pain, typically hanger-type pain.
Pain, abdominal pain and burning pain in the lips** are not easy.
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Parkinson's disease (Parkinson'S disease (PD) is a common degenerative disease of the nervous system in middle-aged and elderly people, characterized by four major symptoms: resting tremor, stiffness or stiffness of limb muscles, bradykinesia, and postural balance disorders.
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In recent years, Parkinson's disease has a high incidence in middle-aged and elderly people, which has a great impact on people's normal life and work. But which one is it for Parkinson's? Most people don't know much about this issue.
In fact, Parkinson's disease is a functional brain disease that mainly affects a person's motor function.
1. What is Parkinson's?
Parkinson is a functional brain disease that mainly affects people's motor functions, such as involuntary shaking of hands and feet, not moving when stationary, holding chopsticks, not moving when drinking, reduced shaking, and severe shaking in some patients, these actions can be completed. About 60% to 70% of patients begin with limb tremors.
If there are no other symptoms, such as stiff limbs, ineffective movement, fingers can not do fine work, walking without shaking arms, walking can not take out of the legs, or small broken steps after taking a step, forward gait, etc., it cannot be judged as Parkinson's disease, and it is necessary to go to the hospital for some auxiliary examinations, and it can be distinguished from diseases that can cause tremor, such as hyperthyroidism.
2. How can I get Parkinson's?
At present, it is known that the causes of Parkinson's disease are: "decreased" dopamine transmitter secretion in the brain, acetylcholine transmitter production "normal", these two neurotransmitters contain each other, produce "normal" amounts, maintain the normal movement of the body, and this balance is disrupted at the onset of the disease, resulting in Parkinson's disease limb symptoms.
The production of dopamine neurotransmitters does not occur overnight, but gradually decreases, and only after a certain amount is reduced, then obvious limb symptoms appear, so it is often called Parkinson's disease with insidious onset and slow progression. But what exactly causes the decrease in dopamine neurotransmitter production is still inconclusive.
Many experts believe that the occurrence of Parkinson's disease is related to aging, genetic factors, environmental toxins and other factors, and is not caused by a single factor, but the result of multiple factors.
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Presents as a slow rhythmic tremor, often starting in one finger and affecting the entire upper extremities, lower extremities, jaw, lips, and head. Typical tremor is resting tremor, which refers to the involuntary tremor of the patient at rest. It mainly affects the upper limbs, and the hands tremble like rubbing balls, and sometimes the lower limbs tremble.
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Parkinson's disease can easily cause a pain in the body, which is mainly affected by two factors
Clause. 1. For patients with middle and advanced Parkinson's disease, due to muscle tonic-clonic and reduced activity, it is easy to have physical pain, which is a manifestation of Parkinson's disease in the middle and late stages. Passive movement of the limbs can be given, and muscle massage can be given to relieve the pain.
Clause. 2. Pain in patients with Parkinson's disease is related to anxiety and somatization disorder. Because Parkinson's patients are prone to comorbid anxiety somatization disorder, depression, and physical pain. An anxiety and depression scale can be made, and anti-anxiety or antidepressant drugs can be given, such as lespro, duloxetine and other drugs taken orally.
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Disease analysis: Parkinson's patients last about 10 years, and the course of the disease will enter an advanced stage. In the early stage of Parkinson's disease, patients generally do not have obvious impairment in their ability to take care of themselves, but Parkinson's disease is a disease that cannot be improved.
The vast majority of patients will reach an advanced stage about 10 years after the onset of the disease, at which point patients will develop severe impairment in their ability to take care of themselves.
Condition recommendation: Patients with Parkinson's disease need to be undergoing neurology**. In the early stages, patients can choose monotherapy**, such as levodopa, dopamine agonists, etc.
In advanced stages of the disease, a combination of levodopa** is usually required, such as levodopa in combination with a monoamine oxidase inhibitor or in combination with a dopamine agonist.
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