What is the polarity of a drug and what does the polarity of a drug mean Why is the polarity small

The answer to your question is as follows: A covalent molecule is polar, which means that the charge distribution within the molecule is not uniform, or that the positive and negative charge centers do not coincide. The polarity of a molecule depends on the polarity of the individual bonds within the molecule and how they are arranged.

In most cases, polar molecules have polar bonds in them, and non-polar molecules have non-polar bonds in them. However, non-polar molecules can also be made up entirely of polar bonds. As long as the molecule is highly symmetrical, the positive and negative charge centers of each polar bond are concentrated in the geometric center of the molecule, so that the polarity of the molecule is eliminated.

Such molecules are generally linear, triangular, or tetrahedral in shape. The polarity of the molecule has a great influence on the solubility of the substance. Polar molecules are soluble in polar solvents, and non-polar molecules are soluble in non-polar solvents, that is, "similar solubility".

Polar molecules such as sucrose, ammonia, and ionic compounds such as sodium chloride are easily soluble in water. The components of organic matter with long carbon chains, such as oils and oils, are mostly insoluble in water, but soluble in non-polar organic solvents.

dissolving the drug in a polar liquid to compound into a polar drug; Or dissolve the drug in water, use its aqueous solution as the base solution, and then make a polar drug. At the same time, the "external gravity" is applied to the lesion in vitro, which can control the polar drug and guide the drug to stay in the patient according to the position of the patient, so as to increase the concentration of the drug in the patient, enhance the efficacy, and reduce the risk to other organs.

What does the "polarity" of the drug mean that the positive and negative charge centers in the molecule do not coincide, and from the perspective of the whole return to the molecule, the distribution of the charge is uneven and asymmetrical, such a molecule isPolar moleculestoPolar bondsThe bound diatomic molecule must be a polar molecule, and the polyatomic molecule bound by a polar bond depends on the structure, such as ch4, which is not a polar molecule.

About solubility.

In general, polar molecules are easily soluble in polar solvents.

e.g., leaking skin wheel water), non-polar molecules are easily soluble in non-polar solvents (fat-soluble). This is often referred to as resemblance dissolving.

Absorption of fat-soluble drugs:

Studies have shown that most fat-soluble drugs are absorbed faster by the body in the morning than in the evening. Therefore, when taking these medications, especially once a day, try to take them at night.

For example, isosorbide nitrate is administered in the morning and peaks significantly shorter than in the evening. However, general drugs do not require quick relief, because the absorption is fast, the metabolism will be faster, and it is difficult for the drug to reach the peak concentration in the body, so for fat-soluble drugs, choose to take it at night.

Polarity: the direction or attraction of an object to a particular thing (e.g., tilt, feeling, or thought) that exhibits opposite intrinsic properties or forces in opposite parts or directions; A tendency or tendency in a particular direction, a specific positive or negative state to the poles or to an electrification (e.g., of an object). In chemistry, polarity refers to the non-uniformity of the charge distribution in a covalent bond or a covalent molecule.

If the charge is not evenly distributed, the bond or molecule is said to be polar; If it is homogeneous, it is said to be non-polar. Some of the physical properties of a substance like solubility, melting boiling point, etc., are related to the polarity of the molecule.