What medicines should not be used in combination with antibiotics?

With the popularization of the combination of traditional Chinese and Western medicine, its compatibility should also be strictly controlled. Unreasonable compatibility not only affects the efficacy, but also produces toxicity, and the following traditional Chinese medicines should not be used in combination with antibiotics.

Keels, pearls, oysters, sea clams, etc., which contain calcium, are easy to form chelates with tetracycline antibiotics to affect absorption and reduce efficacy.

Blood charcoal, mugwort leaf charcoal, and calcined corrugated alder have strong adsorption power, which can reduce the absorption of antibiotics in the gastrointestinal tract. Shenqu and malt contain a variety of digestive enzymes, and some antibiotics inhibit their activity and weaken their function of eliminating food and strengthening the stomach.

Gypsum, erythrite, talc and other magnesium, aluminum, iron ions and tetracycline antibiotics are combined to form chelates and reduce the efficacy. Xuanhu, mast, licorice, etc. inhibit the secretion of gastric acid, affect the absorption of tetracycline, Sijiqing and Huangyaozi can damage the liver, and the combination with tetracycline increases the toxic effect. Schisandra, hawthorn, and black plum can acidify urine, so that the efficacy of alkaline tetracycline and erythromycin is reduced.

Ginger, gentian, and raffle wood promote gastric acid secretion, and erythromycin destruction increases. Belladonna traditional Chinese medicine inhibits peristalsis, delays gastric emptying, prolongs the residence time of erythromycin in the stomach, and increases destruction. The tannins contained in elm, knotweed, pomegranate peel, etc., can bind to erythromycin and hinder erythromycin absorption.

Traditional Chinese medicine laxatives such as croton, black and white clown, etc., can accelerate the passage of erythromycin through the intestine and affect its absorption.

The protein and its hydrolysate (a variety of amino acids) contained in rhino horn and pearl can resist the antibacterial effect of berberine and reduce the efficacy.

Yin Chen has an antagonistic effect on the antibacterial effect of chloramphenicol, which can reduce the efficacy of chloramphenicol.

Traditional Chinese medicines containing tannins, such as gallnut, chebula, pomegranate peel, elm, jujube bark, Sijiqing, rhubarb, etc., can be combined into tannins precipitate when taken with griseofulvin, nystatin, lincomycin, etc., which are not easily absorbed. Alkaline Chinese medicine borax and amino acid glycoside antibiotics such as streptomycin, kanamycin, gentamicin, neomycin, and tobramycin can be taken at the same time, which can increase toxicity. When borax is used with weakly acidic carbofurandine, penicillin, and pioneer mycin, it can reduce the reabsorption of these drugs and reduce the blood concentration.

When a patient takes more than two antibiotics at the same time, the more drugs used, the higher the incidence of adverse reactions.

1.In general, the course of antibiotics is about 7 days, and the elderly, children, pregnant women, and people with poor liver and kidney function should reduce it. Of course, antibiotics serve prescription drugs.

2.Each drug takes effect at a certain speed, and too close to each other will cause the concentration of the drug in the blood to be too high, which may lead to nerve or liver and kidney damage; If the interval is too far away, the evolution of the drug in the blood is not enough, and the power against bacteria will be weakened, and drug resistance will also be generated. So friends, it is recommended that you take antibiotics must be taken 8 hours a day, three times a day.

In addition, contraceptives and lactase are not suitable for taking together with antibiotics, which will weaken the efficacy of the drug, which also needs to be paid attention to by patients.

Other than that, there are only certain foods that cannot be combined.

1. Cephalosporins cannot be eaten with alcohol, and the cephalosporin structure contains tetrathiotetrazole side chains, which will inhibit the activity of acetaldehyde dehydrogenase in liver cells, resulting in acetaldehyde can not be normally oxidized and metabolized, resulting in acetaldehyde agglomeration, resulting in disulfiram reaction. Symptoms include flushing and swelling of the face, dizziness, headache or difficulty breathing, drop in blood pressure and even shock.

When glucose is converted into hepatic glycogen in the liver, a large number of drug enzymes are released, causing the drug to prematurely destroy the active components of the drug; At the same time, the alkaline environment of glucose also has a certain damage to the drug.

2. Metronidazole can not be eaten with wine, acetaldehyde, the product of the middle cavity of alcohol capitalization, has a certain toxicity, metronidazole will inhibit the metabolism of acetaldehyde in the body, causing the body acetaldehyde accumulation poisoning reaction, manifested as bitter mouth, nausea, vomiting and dyspnea.

Metronidazole cannot be eaten with calcium-rich milk, and calcium ions can combine with drugs to form insoluble precipitates, which destroys the nutritional value of food and reduces drug efficacy.

3. Erythromycin cannot be eaten with foods rich in calcium, phosphorus and magnesium, such as milk, beans, kelp, fruits, etc., which will delay the effect of the drug and the absorption of the drug, and reduce the antibacterial effect of the drug.

Erythromycin cannot be eaten with alcoholic foods, and taking it together will increase the toxicity of erythromycin and damage liver function.

4. Tetracycline complexes with metal ions in alkaline foods to produce metal complexes that are difficult to absorb, which interferes with the body's metabolism and absorption of drugs; Alkaline foods will also neutralize with gastric acid in gastric juice, which will reduce the solubility of tetracycline and reduce the amount of drugs that the body can absorb, making it less effective.

1. Avoid alcohol and alcoholic beverages.

Children should avoid some alcohol-containing foods and drugs, such as sake lees, Huoxiang and pure mu Zhengqi water.

2. Avoid vinegar. Acetic acid can aggravate stomach acid, and some antibiotic drugs are alkaline, and the two work at the same time, which may neutralize the efficacy of the drug and affect the absorption of the drug.

3. Avoid fruit juice.

Do not drink fruit juice and eat fruit within two hours of taking antibiotics, fruit juice contains fruit acids, which will accelerate the dissolution of antibiotics and affect the efficacy of the drug.

4. Supplement nutrients such as calcium, magnesium, zinc, etc.

Metal ions such as calcium, magnesium, iron and phosphorus will combine with some components in antibiotics and easily form substances that are difficult to dissolve and absorb, reducing the efficacy of the drug. If your child is taking antibiotics, some calcium, iron, zinc, and even seafood that is rich in these elements should be stopped.

5. Do not use milk to feed medicine.

Milk, tofu, chocolate and other foods are rich in tyramine, and some ingredients in antibiotics can inhibit the activity of monoamine oxidase, resulting in the accumulation of tyramine, causing the body to release endogenous norepinephrine, which may cause high blood pressure. After your child takes the medicine, wait at least two hours before drinking milk.

5. Seafood is rich in calcium, magnesium, iron and phosphorus and other metal ions, which will combine with guitaramycin, which is easy to form substances that are difficult to dissolve and absorb, and reduce the efficacy.

6. Furazolidone can inhibit the oxidation of alcohol and the decomposition of Xiangcong, hinder the degradation of acetaldehyde, and cause acetaldehyde poisoning.

Milk, tofu, chocolate and other foods are rich in tyramine, furazolidone will inhibit the activity of monoamine oxidase, resulting in the accumulation of tyramine, causing the body to release endogenous norepinephrine, together with an increase in blood pressure, may cause high blood pressure. In particular, patients with high blood pressure must pay special attention.

7. Improper use of antibiotics will cause damage to the body, and antibiotics must not be used without authorization. There are many types of antibiotics, and the contraindications for the use of antibiotics are far more than those mentioned above; Pregnant women and children are special populations, and there are also requirements for the use of antibiotics; Antibiotics may also be affected by medications used in patients with other medical conditions, so it is best to consult your doctor about the type of antibiotic to use safely and the dose of the drug.

In the case of infectious diseases, in order to increase the efficacy of antibiotics, shorten the course of the disease, and reduce the emergence of bacterial resistance, we often use two or more antibiotics together, which is called "combination of antibiotics".

Modern clinical pharmacology believes that the combination of antibiotics may occur in the following four situations:

1. Enhancement: The effect of the two antibiotics when combined is greater than the sum of their effects when used alone;

2. Additive effect: the effect of their combination is equal to the sum of the effects of the two antibiotics alone;

3. Irrelevant effect: the effect of the combination of two antibiotics is only equivalent to the effect of one of the antibiotics with a strong effect;

4. Antagonism: The effect of the two antibiotics when combined is less than the sum of their effects when they are used separately. The purpose of our combined use of antibiotics is to enhance the efficacy and shorten the course of the disease, if the combination of antibiotics is an irrelevant effect or antagonistic effect, this not only reduces the efficacy, is not conducive to shortening the course of the disease and speeding up the recovery, but also increases the incidence of adverse reactions.

Clinical practice has proved that when two bactericidal antibiotics are used in combination, there are more opportunities for them to produce enhancement or synergistic effects, such as the common penicillin combined with gentamicin, the reason why the two antibiotics show an enhanced effect after the combination is mainly because penicillin inhibits the cell wall synthesis of sensitive bacteria during the reproduction period, while gentamicin inhibits the protein synthesis of sensitive bacteria in the quiescent stage, and the two drugs act on bacteria through different ways and accelerate bacterial death; When two rapid bacteriostatic antibiotics are used in combination, there will be additive effects, such as erythromycin combined with chloramphenicol, erythromycin combined with tetracycline, or tetracycline combined with chloramphenicol, etc., the reason why these rapid antibacterial antibiotics are combined is that they all act by inhibiting the protein synthesis of sensitive bacteria, and the same pathway of action; When bactericidal and bacteriostatic antibiotics are used in combination, they are generally mostly manifested as irrelevant effects or antagonistic effects, such as penicillin combined with erythromycin, tetracycline or chloramphenicol, etc., because penicillin is a rapid bactericidal antibiotic, which has a strong effect on bacteria in the breeding period, while erythromycin, tetracycline and chloramphenicol are rapid bacteriostatic antibiotics, which can quickly inhibit the reproduction of sensitive bacteria. Penicillin also virtually reduces the bacteriostatic ability of erythromycin, tetracycline and chloramphenicol.

According to the statistics of clinical pharmacists, about 60% and 70% of the combined use of antibiotics show unrelated effects or additive effects; Approximately 20% to 25% of cases show a reinforcing effect; In about 10% to 15% of cases, it is manifested as a mutual antagonistic effect.

In the clinical use of antibiotics ** infectious diseases, where the use of an antibiotic can achieve the first purpose, try not to use the second and third, only for those infections are particularly serious, it is estimated that there are more than two bacteria co-infection, or it is estimated that it is difficult to control the infection with one antibiotic, only consider the combination of antibiotics.

Chinese patent medicine can be taken with antibiotics, I had a cold and cough and sneezed for a few days, so I went to the pharmacy by myself