How do superbugs fight antibiotics by closing their pores?

According to foreign media New Atlas, the emergence of "superbugs" is worrying - these bacteria become resistant to antibiotics and could eventually make the most basic infections fatal again. Now, researchers at Imperial College London have discovered that a high-priority superbug resists drugs by closing its pores, a discovery that could lead to new ways. <>

The bacteria involved in the study are called Klebsiella pneumoniae and, as the name suggests, can cause certain types of pneumonia. Unfortunately, these types of infections are increasingly resistant to antibiotics, including a drug called carbapenems, which is considered the last line of defense against this type of bacteria.

As a result, scientists involved in the new study began to analyze how bacteria develop resistance to these drugs. The team compared carbapenem-resistant strains of Klebsiella pneumoniae with other non-carbapenem strains in an attempt to find structural differences. <>

Recently, they discovered that resistant bacteria have modified a protein called OMPK36 and, in some cases, lost it altogether. This protein is responsible for creating pores in the cell wall of bacteria, through which drug molecules enter the cell to kill bacteria. By reducing OMPK36, bacteria have fewer and smaller pores and are therefore better resistant to antibiotics.

Now that we have a better understanding of the process, scientists may try to come up with new techniques and drugs that may interfere with this mechanism. But this brings new challenges. "Modifications used by bacteria to fight antibiotics are difficult to address," said GAD, the study's principal investigator

Frankel said. "Any drug that resists this defense mechanism is likely to be blocked by a closed 'door'. But we want to be able to design drugs that 'lock the door', and our data provides information to help scientists and pharmaceutical companies find ways to develop these new drugs." ”

Superbugs have a special structure, and they feel the antibiotic, so they close the pores.

That's what makes superbugs special, isn't it, they're all so powerful.

These bacteria develop resistance to antibiotics and can eventually make the most basic infections lethal again.

Because it is a reaction of his own, which is the self-protection of superbugs.

Superbugs close their pores to fight antibiotics and cleanse themselves.

It is through a change of one's own nature that such a change is made to adapt to the change of the environment.

Superbugs may have cell walls, cells, sap cells, and these, and if they want to shield themselves from antibiotics, they should tighten their cell walls or hide their nuclei.

Self-reaction, you can observe the mimosa, that's how it works.

I think it should be closed through some reactions of my own.