How does polycystic kidney disease occur and how does polycystic kidney disease occur

Polycystic kidney disease is mostly inherited through parental genes, but some patients are caused by genetic mutations during embryonic formation. For polycystic kidney disease, which is hereditary kidney disease, it is not preventable, but it can reduce the aggravating factors, patients need to pay attention to rest, quit smoking and alcohol, and if kidney function damage occurs, pay attention to a high-quality low-protein diet and eat less legumes.

Polycystic kidney kidney is a genetic disorder that affects the kidneys and other organs. There are two types of the disease, autosomal recessive (infantile) polycystic kidney disease, which begins in infancy; Autosomal dominant (adult) polycystic kidney disease, usually found in young middle age, can occur at any age. Gene decoding can accurately and quickly identify the patient's pathogenic genes, design the best scheme according to the pathogenic genes, guide eugenics, and avoid offspring or second children from getting sick again.

The abnormal proliferation of intraglomerular epithelial cells in patients with polycystic kidney disease is one of the distinctive features of polycystic kidney disease, which is in a state of incomplete maturation or redevelopment, which highly indicates that the regulation of cell development and maturation is impaired, so that the cells are in an immature state, thus showing strong proliferation. Abnormal epithelial cell transport is another significant feature of polycystic kidney disease, which is manifested by the subunit combination, distribution and active expression of Na+-K+-ATPase, which is closely related to cell transport. Abnormal cell signaling and changes in ion transport channels. Dysplasia of the extracellular matrix is the third distinctive feature of polycystic kidney disease.

There are many causes of polycystic kidney disease. For example, congenital polycystic kidney disease is caused by congenital dysplasia, and some genes are caused by some other factors. Only by correctly grasping the symptoms can patients live a better life and have a healthy body.

1. Gene mutations.

For polycystic kidney disease, it is mostly inherited through parental genes, which is divided into autosomal dominant inheritance and autosomal recessive inheritance, but some patients with polycystic kidney disease are neither parental inheritance nor congenital dysplastic polycystic kidney disease, but gene mutations at the time of embryogenesis. In the process of embryogenesis, due to the action of various factors, the gene mutations form polycystic kidney disease, although this situation is rare, but it can still occur, therefore, some patients with polycystic kidney disease can have no parental genetic history.

2. Causes of kidney cysts with congenital dysplasia.

Congenital dysplasia can produce a variety of diseases, for cystic nephropathy, it can mainly cause medullary sponge kidney, dysplastic polycystic kidney disease, etc., and the genes of congenital dysplasia are generally not abnormal, so it is different from genetic inheritance or gene mutation.

3. Toxins act on the human body, which can cause damage to various cells, tissues and organs, resulting in diseases and even life-threatening, and are also one of the main reasons for genetic mutations and congenital development abnormalities. Common toxins such as pesticides, certain chemicals, radiation, pollution, etc. In particular, some drugs are also nephrotoxic and can cause kidney damage if used incorrectly, including:

Kanamycin, gentamicin, sulfonamides, rifampicin, indomethacin, and other Western medicines, as well as centipede, strychnine and other traditional Chinese medicines.

4. Various infections.

Infection can cause abnormal changes in the internal environment of the body, thereby creating environmental conditions conducive to changes in cyst genes, so that the activity of internal factors of cysts is enhanced, which can promote the formation of cysts; Any infection in any part of the body will enter the kidneys through the blood and affect the cyst, if the cyst is infected, in addition to aggravating the clinical symptoms, it will also promote the cyst to further accelerate the growth rate and aggravate the kidney function damage. Common infections include upper respiratory tract infections (including colds), urinary tract infections, gastrointestinal tract infections, ** infections, trauma infections, device infections, etc., that is, whether it is a bacterial infection or a viral infection, it can have a great impact on cysts.

The above are several reasons for polycystic kidney disease, more importantly, polycystic kidney patients must be correct according to their own symptoms, in order to achieve the ideal effect, I wish you a happier life as soon as possible.

Polycystic kidney disease is a common hereditary kidney disease characterized by multiple cysts of different sizes in both kidneys, which progressively enlarge and eventually destroy the structure and function of the kidneys, leading to end-stage renal failure. Generally, pay attention to rest, avoid smoking, avoid drinking tea, coffee and alcohol-containing beverages, avoid chocolate, have a low-salt diet when you have high blood pressure, and recommend a low-protein diet in the late course of the disease. Most patients do not need to make lifestyle changes or limit physical activity in the early stages.

When the cyst is large, strenuous physical activity and abdominal trauma should be avoided. Patients should be followed up regularly. Complications should be actively controlled, and renal replacement should be taken in a timely manner for patients with end-stage renal disease**.

Surgery can be used to remove the enlarged cyst in patients who do not respond to conservative**, and the choice of regimen for different patients should depend on the severity of symptoms, the degree of lesions, the number and location of cysts, the level of renal function, and the degree of complications.

?Due to the insidious nature of polycystic kidney disease in the early stage of its onset, the disease often develops very rapidly during the onset of the disease, which undoubtedly creates a lot of difficulties for the diagnosis and ** of patients. The method of disease focuses on early, so early detection plays a good role in the disease.

Let's analyze the pathogenesis of polycystic kidney disease: 1. Renal insufficiency: This is also one of the common symptoms that cannot be ignored in patients with polycystic kidney disease.

The onset of polycystic kidney disease can also cause the appearance of abdominal masses to a certain extent. It is mostly felt in the upper abdomen on both sides, and the lumps vary in size. Therefore, patients must not be careless about the appearance of abdominal mass.

3. Hematuria: Hematuria is one of the earliest symptoms of polycystic kidney disease, often the first manifestation of polycystic kidney disease, and more than half of the patients can appear, mainly intermittent gross hematuria. It has caused and bad effects on the majority of polycystic kidney disease patients.

The above introduction to the characteristics of polycystic kidney disease is believed to have some understanding of patients.