Is there a problem with the children of the three generations of blood relatives?

The risk of collateral third-generation blood relatives is doubled. Within three months of pregnancy, diazepam tablets have the risk of increasing fetal teratogenicity, and pregnant women can become addicted to long-term use, causing newborns to show symptoms of drug withdrawal, irritability, tremor, vomiting, and diarrhea; Medication in the third trimester of pregnancy affects the central nervous system activity of newborns. Medication before and during delivery can lead to weak neonatal muscle tone and should be contraindicated.

Once or twice once in a while should be fine though, and your dosage is small.

According to expert estimates, each normal person may carry several or even a dozen harmful recessive alleles, and intermarriage will make these recessive alleles have more chance of encountering and produce genetic abnormalities. Half of the human nuclear genome comes from the father and half from the mother, and in the case of consanguineous marriage, the chances of two identical problematic genes joining together are far greater than in non-consanguineous people. How risky is it that consanguineous marriages are involved?

Let's calculate it from the following mating pattern:

If there is a first-degree separation between first-degree and second-degree cousins, which means that there is an intermarriage between a first-degree cousin and a first-degree cousin, then the inbred index is 1 32 and so on for the other types. Suppose the proportion of a genetic disease in the population is 1 in 1000:

The risk of disease in offspring of non-consanguineous marriages is 1 500 1 500 1 4 = 1 1000000 (1 in million);

The risk of disease in the offspring of second-degree cousins is 1 500 1 64 1 4 = 1 128000

The risk of disease in the offspring of first-degree cousins is 1 500 1 16 1 4 = 1 32 000

The risk of disease in offspring of sibling marriage is 1 500 1 4 1 4 = 1 8000

The risk of second-degree consanguineous relatives is doubled compared with non-consanguineous marriages; The risk of first-degree consanguineous relatives is increased by 31 times; The risk rate of sibling marriage is 125 times higher than that of normal random marriage!

It's been three generations, and it may not have any impact (and I'm not sure) I remember hearing the neighbor's aunt tell me that his husband was his cousin, and their three children are all fine at present. Diazepam tablets are sedative and hypnotic drugs, pregnant women, pregnant women, and newborns should be used with caution, and it is recommended that your wife go to the hospital for a check-up.

Collateral blood relatives within three generations are forbidden to marry, this is a legal requirement, but it is definitely scientifically justified. I think it's best to go to the hospital for a check-up and listen to the advice of a doctor or a specialist if you really want this child.

Children born to direct blood relatives and collateral blood relatives within three generations may have genetic diseases, and even if this generation does not have them, they may also manifest themselves in the offspring.

Test for DNA, or blood tests for close relatives, improve preconception testing, and give detailed guidance in combination with your specific situation...

It is best to do a genetic test, some genetic disorders can be recognized, especially recessive or intergenerational genetic diseases. Some genetic disorders are inherited with little chance of being separated from each other, but have a high chance of being inbred together. However, it is also possible to monitor the fetus and cancel the pregnancy in time if there is an abnormality.

Black and white ultrasound has no effect on the fetus, is cheap, starts at a longer interval, and is monitored once a month later. Not only responsible for your family, responsible for your children, but also responsible for society!

Even if there is a 99% chance of a teratogenic factor, maybe you happen to be the lucky 1%; Maybe there is only a 10% chance of inheriting some recessive genetic diseases, maybe you just happened to encounter them, then there is no way, just pay attention to more examinations during pregnancy. For example, Down's screening at 4 months, and screening for various neurological malformations at 6 or 7 months should be done.

Valium (diazepam) is generally not affected by small doses of diazepam, so don't be too nervous. Pregnant women should maintain a light and cheerful mood, strengthen nutrition, pay attention to rest and moderate exercise.

From a medical point of view, close relatives are not allowed to marry within three generations, but with the modern medical level, there should be no big problems with constant monitoring. When I was three months old, I went to the hospital to check the amniotic fluid and see if there was any problem. Generally speaking, the first trimester of pregnancy is the most critical, because this period is in the gene expression stage, which is the stage of forming organs such as brains and nerves, and generally do not take medicine.

Because the drug may have "three causes" (teratogenic, carcinogenic, mutagenic), it is said that if you take the drug, you must monitor it from time to time, and if there is a problem, induce labor in time.

There is no problem necessarily. Inbred marriage can only be said to have a greater chance of onset, because many diseases controlled by recessive genes, in the consanguineous system, it is very likely that both parties carry the same recessive pathogenic gene, and when the two are combined, the two recessive ones show dominant symptoms, so the disease occurs.

Distant relatives do not necessarily give birth to children who are completely normal, the reason is the same, but because distant relatives are less likely to carry the same recessive disease-causing gene.

Therefore, whether it is a distant relative or a close relative, it is necessary to have a check-up at any time after pregnancy, and to do a good job of pregnancy health care, so as to avoid genetic mutations, which may also cause malformed fetuses.

In your case, of course, the probability of developing a genetic disease is higher than in the normal case.

But I think that the question of having a child is not a question of not having a child if you get sick, but not having a child if you don't get sick, the key is whether you and your husband and wife are mentally prepared: that is, if your child really has a disease that cannot be cured in your lifetime, are you willing to spend the rest of your life taking care of that child? Do you have the ability to withstand an environment that is different from that of a normal family?

There is also a couple in my hometown who are close relatives who are married, and the child they have has a bit of a problem with intelligence, and they can't keep up with the children of the same age, but I haven't heard any bad rumors about their family for so many years, and a food wholesale store opened by their family in their hometown is getting better and better every year, and the child there, although the intelligence is not as good as that of a normal person, but he maintains the innocence of a child, and he does not have the messy thoughts of some people who are his age now, and I think this family is quite happy Although I can't guarantee that their family will be as happy as they are in the next few decades (their children are almost adults, according to country customs, I think the biggest headache for his parents is his marriage).

First of all, there is no violation, because more than three generations.

Congratulations!!! If you are afraid of a genetic disease!!

1. It's hard to say about probability, but it's not much of a problem from the perspective of probability.

But drinking water has a time when the teeth are plugged, so even if the two are not related by blood, it is not foolproof, and the marriage of close relatives does not necessarily give birth to fools.

2. Medical examination is the key, and some genetic diseases can be detected.

Have faith in medicine.

3. I don't know about diazepam tablets, you look at the taboo column in the instructions, it's basically fine if you don't write it, people still have to take medicine when they're sick, but you need to pay more attention.

If you are pregnant, you should pay more attention to hygiene, do some appropriate exercise, enhance your resistance, and reduce the invasion of diseases, which is the key.

Finally, congratulations on becoming a father!!

Is the landlord still there? I have the same concerns as you and would like to ask how your child is doing.

Is there a problem that you can't know until the child is born, are you afraid of getting sick, don't you want a child? Fear of burden??? Science says that there is a certain percentage, but it doesn't say that it must be, isn't it, don't be afraid, support you.

Lineal consanguinity: Lineal blood relatives in the legal sense include two situations, one is relatives who are from the same ancestor and have natural blood ties, such as grandparents, parents, children, etc.; The second refers to the fact that there is no natural blood relationship, but the status is legally determined to be equal to that of blood relatives, such as the relationship between adoptive parents and adoptive children is equivalent to direct blood relatives.

Collateral consanguinity within three generations: Collateral consanguinity refers to relatives with indirect consanguinity, that is, non-direct consanguinity from the same ancestor, such as siblings, cousins, cousins, uncles and aunts, nieces, nieces, etc. The so-called "within three generations" is counting from oneself, oneself is the first generation, to the parents Hanmin is the second generation, to the grandparents and grandparents are the third generation; Counting down from oneself, oneself is the first generation, to the second generation of children, and to the third generation of grandchildren and grandchildren.

Blood relatives other than direct blood relatives within three generations are collateral blood relatives within three generations.

Close kinship: In-law refers to the kinship relationship mediated by marriage, which mainly refers to the parents of the spouse, the siblings of the spouse and their spouses, the spouses of the children and the parents of the children's spouses, and the spouses of collateral blood relatives within three generations.

The concept of 1. 3rd generation collateral blood relatives.

Lineal blood relatives are relatives who are directly related by blood, that is, the upper and lower generations of relatives who have given birth to themselves and the relatives they have given birth to. Both the father and the mother are included. For example, parents and children, grandparents and granddaughters, maternal grandparents and granddaughters, etc.

Collateral blood relatives are relatives who are indirectly related by blood, that is, relatives who are not direct blood relatives but are of the same origin as themselves in blood. A collateral blood relative within three generations is a relative who is related to oneself by blood within three generations.

The three generations here are three generations counted as one generation from the beginning of themselves. (To put it simply, consider whoever is in charge of the first generation, and look up until they are born to the same parents). For example:

1. Brothers and sisters are from the same parents, they are the first generation, and their parents are the second generation, so the brothers and sisters are collateral blood relatives within the second generation;

2. Uncles, uncles, aunts, brothers, cousins, cousins, and cousins are from the same grandparents, and they are the first generation, and their fathers and uncles, uncles, and aunts are the second generation, and their grandparents are the third generation, and these relatives are all from the third generation, so they are collateral blood relatives within three generations with their uncles, uncles, aunts, fathers, brothers (cousins), cousins, and cousins;

3. Uncles, aunts, cousins, cousins, maternal brothers (aunts), maternal sisters (aunts) and themselves are from the same maternal grandparents, they are the first generation, their mothers and uncles and aunts are the second generation, and their maternal grandparents are the third generation, and these relatives are all from the third generation, so they are also collateral blood relatives within three generations between themselves and their uncles, aunts, uncles, cousins, maternal brothers (aunts), and mothers (aunts). This kind of expression can be said to be very clear and easy to understand in words, but it is really difficult for people who are new to understand it, so it is good to understand it slowly.

A sibling is a child of his or her father's (uncle). They are also called uncles, brothers and sisters, and cousins. "Kintang" refers to his cousin Lun Xiangda, who has the same grandfather as himself.

A "cousin", also known as a "middle cousin", refers to a female male or female who is a sister of his father or a brother or sister of his mother. There are aunts, uncles and aunts.

An aunt or cousin is a female male or female person who is a member of his or her uncle or aunt.

A sibling is a child of his or her own mother. They are also called aunts and sisters, and cousins.

2. Extrapolation rules.

I am counted as one generation, the previous generation of parents, and the generation of grandparents is three generations.

I am counted as one generation, the next female male generation, and the granddaughter male generation is three generations.

According to Article 1048 of the Civil Code, "Marriage is prohibited between lineal blood relatives or collateral blood relatives within three generations." ”

Estimation of collateral blood relatives:

Count from the two collateral relatives up to the two homologous blood relatives, who themselves are one generation, and if the number of the two sides is equal, the number of either side is their algebra; If the numbers on both sides are not equal, the larger number is used as its algebra.

According to the provisions of China's Civil Code, under normal circumstances, collateral blood relatives within three generations generally include: collateral blood relatives of the second generation and collateral blood relatives of the third generation, which refer to collateral blood relatives who are from the same parents or grandparents or maternal grandparents as themselves. The scope includes siblings, uncles, aunts, aunts, cousins, nieces, nephews.

Relatives beyond this range are not collateral blood relatives within three generations.

[Legal basis].

Civil Code of the People's Republic of China Article 1048 [Circumstances Prohibited from Marriage] Marriage is prohibited for direct blood relatives or Bu Ye Zheng collateral blood relatives within the third generation of songs.

Legal Analysis: Collateral blood relatives within three generations: including collateral blood relatives of the second generation and collateral blood relatives of the third generation, refer to collateral blood relatives who are from the same parents or Huiye's grandparents or maternal grandparents.

The scope includes siblings, uncles, aunts, aunts, cousins, cousins, nieces, and nephews. Relatives beyond this range are not collateral blood relatives within three generations.

Legal basis: Article 1045 of the Civil Code of the People's Republic of China Relatives include spouses, blood relatives and in-laws.

Spouses, parents, children, siblings, grandparents, grandchildren, and grandchildren are close relatives.

Spouses, parents, children and other close relatives living together are family members.