What is the incidence of ALS What is the incidence of ALS?

ALS has an incidence of about 4 to 6 per 100,000 people, and its technical term is amyotrophic lateral sclerosis, which is a chronic, progressive degenerative disease that affects upper and lower motor neurons and their innervated trunk, limbs, and head and face muscles. ALS is caused by genetic factors and predisposing factors. **Method*** Normal breathing, enhanced nutrition, medication**.

Causes of ALS:

1. Genetic factors. This disease is hereditary, and if someone in the family suffers from this disease, it is recommended that the immediate family members check it out to see if they have it, as soon as possible**.

2. Predisposing factors. There are many predisposing factors that can lead to amyotrophic lateral sclerosis, such as smoking, exposure to toxins (such as exposure to organic solvents, pesticides, heavy metals, etc.), history of head trauma, metabolic diseases, autoimmune dysfunction, viral infections, and neuroinflammatory reactions.

**Method: 1. Ensure normal breathing. Noninvasive assisted ventilation can be used for respiratory muscle weakness, and a tracheostomy and ventilator can be given to assist breathing if necessary.

2. Strengthen nutrition. If you can eat, increase your nutrition, eat some foods with nutritional value, and if you have difficulty eating, you can use a liquid diet to eat less and more often.

3. Drugs**. You can take drugs such as lirutai and edaravone under the guidance of a professional doctor.

It can occur at any age, but it is more common in 30 to 60 years of age, and there are more males than females, and the male-to-female ratio is about 3:1. ALS, the most common type of motor neuron disease in clinical practice, is distributed worldwide, with an annual incidence of about 2.1 million and a prevalence of about 6.1 million, with more than 90 cases being sporadic and the remaining 10% being familial (hereditary).

ALS refers to motor neuron disease, which has a prevalence of about 7 to 10 and is also a rare disease. In this disease, patients will have some muscle weakness, such as weakness of head and neck muscles, the head can not be lifted, there will be weakness of the limbs, unable to walk, and even the upper limbs cannot be lifted. However, the patient's feeling is completely normal, and the consciousness is clear, and the whole person is mainly affected by motor function, as if it is frozen, so it is also called ALS.

There are many theories about the pathogenesis of this disease, such as genetic factors, oxidative emergency, autoimmune disorders, etc., specifically, there is no obvious cause of the disease, and there is no special effect.

ALS, also known as amyotrophic lateral sclerosis, is a rare neurodegenerative disease, in which patients mainly manifest as weakness, atrophy, and bulbar paralysis of skeletal muscles, and its causes are several ways:

1. Immune factors, clinical examination often finds that the patient's immune function is abnormal, and the number of immune complexes and immunoglobulins in the body is abnormal.

2. Deficiency of trace elements, such as metal elements and other trace elements, is a phenomenon found in patients with ALS.

3. Genetic factors, according to clinical investigations, ALS is an autosomal inherited disease, and there may be a 5%-10% chance of being passed on to the next generation according to the difference between dominant and recessive genes.

The incidence of ALS is about 1 to 3 per 100,000 per year, and the prevalence is about 4 to 8 per 100,000 per year.

The scientific name for ALS is motor neuron disease, which is a neurodegenerative disease with an incidence of about 3 to 7. The pathogenesis of this disease is not particularly well understood, and may be related to genetic factors, toxicity of excitatory amino acids, neurotrophic disorders, major trauma and environmental factors, and immune dysfunction. Patients have a slower onset of illness.

The incidence of amyotrophic lateral sclerosis in China is about 4 per 100,000. It mostly occurs in the case of people over 40 years old. There is no very clear ** and other situations for the time being.

There's no point in worrying about you. Worrying about such a small probability will only affect your normal life. Don't overthink it.

ALS is a disease that can occur at all ages, so it can occur from young age to advanced age. However, the age of onset is relatively concentrated, and the age of onset is reported in foreign literature to be 30-60 years old, and most patients are over 45 years old, and there are more males than females. In 2009, the China ALS Cooperative Group, composed of 10 hospitals in Beijing and other domestic hospitals, carried out a multi-center registration study.

At that time, 455 ALS patients were counted, and the results showed that the average age of onset of patients was in the years, and the peak age of onset of ALS was 55-59 years and 45-49 years old for men and women, respectively. Therefore, the age of onset is later in men and slightly less in women, but the age is relatively early. From 2010 to 2015, the average age of diagnosis of ALS in Beijing was years.

ALS people of different age groups have slightly different onset and manifestations. Patients with early onset are more likely to have a family history than those with early onset; Sporadic cases are more common in patients with a later onset of the disease.

ALS generally refers to amyotrophic lateral sclerosis, which is the most common classic form of motor neuron disease, which generally takes about 3-5 years from the occurrence of the lesion to the final death of the patient, and most of them have a poor prognosis.

Usually the age of onset is about 30-60 years old, most patients are over 45 years old, more men than women, the common first symptom is one or both finger activities clumsiness, weakness, followed by atrophy of small muscles of the hand, with the thenar muscle, thenar muscle, interosseous muscle, vermiform muscle is the most obvious, can gradually affect the forearm, upper arm, shoulder girdle muscle, with the prolongation of the course of the disease, muscle weakness and muscle atrophy will gradually expand to the trunk, neck, and finally involve the facial muscles, throat muscles. Generally, it takes about 3-5 years from the occurrence of the lesion to the final death of the patient, and most of the prognosis is poor.

ALS refers to amyotrophic lateral sclerosis. It is one of the most common types of motor neuron disease. The age of onset is generally between 30 and 60 years old, and most patients do not develop it until they are over 45 years old.

Men are more likely to develop the disease than women. Its pathogenesis is not fully understood, but studies suggest that it may be related to viral infections, immune abnormalities, genetic factors, certain metal poisoning, or B vitamin deficiencies, as well as abnormal secretion of some neurotransmitters.

ALS usually begins between 30 and 60 years of age, with most patients suffering from ALS over the age of 45. There are more cases in men than in women, and ALS mainly refers to amyotrophic lateral sclerosis, which is one of the most common types of motor neuron disease. ** and pathogenesis are not well understood, and may be related to viral infections, immune dysfunction, genetic factors, certain metal poisoning, or vitamin deficiencies.

June 21 is the World "ALS" Day, one of the five major terminal diseases listed by the World Health Organization, along with cancer and AIDS. But ALS is not as much of a concern as cancer and AIDS. In recent years, with the "Ice Bucket Challenge", this disease has gradually attracted everyone's attention.

ALS people are actually amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND). Stephen Hawking just got this disease.

At present, the mechanism and mechanism of ALS are not very clear, and it is very complex and difficult to understand, including inflammation and infection, immunity, trauma, poisoning, malnutrition, trace element deficiency, etc. In order to better ** patients, medical personnel are looking for ** and mechanisms. Some scholars believe that familial inheritance is one of the most important causes.

As of January 2019, according to data, there are more than 120,000 ALS patients in China. Frostbite is common in middle-aged and elderly patients (between 40 and 60 years old), and the incidence is twice as high in men as in women. However, with the emergence of environmental pollution and other problems, the age and gender factors of the affected population have been broken.

Distal limb paralysis and weakness require prompt screening and diagnosis. The early clinical manifestations of ALS are the damage of upper and lower motor neurons, mainly due to the movement variation of the patient's limbs. Care must be taken when the patient presents with weakness, muscle atrophy, muscle throbbing, or affecting the throat to swallow, speak, breathe, etc.

In severe cases, because the patient's ability to swallow is reduced, it is easy to choke and need a gastric tube or gastrostomy. For people who struggle to breathe, they may need to be put on a ventilator.

Therefore, when the patient finds that the distal end of the limb, especially the hand, the interosseous muscles, vermiform muscles, thenar muscles, etc., are weak, the muscles are atrophied, not full, or there is a flesh beating near the joints, they should be careful and send them to a neuromuscular specialist immediately, preferably to the neuromuscular disease specialist of a major hospital.

Doctors remind everyone that most of these neurodegenerative diseases are related to inflammation and immune disorders, so we need to start paying attention to physical recuperation at a young age, paying attention to exercise and rest, and improving immunity.

The answer is that it is not completely**, and it can only prolong the survival time of patients and delay the disease by taking riluzole tablets.

The famous physicist Stephen Hawking believes that everyone does not know. In addition to his legendary research results, his physical immobility was a matter of concern.

1. What kind of disease is ALS?

ALS, also known as neuronal motility, mainly refers to the gradual weakening and atrophy of muscles such as the ball, limbs, trunk, chest and abdomen after the upper and lower motor neurons of our body are damaged.

On the other hand, patients with ALS are mainly men between the ages of 40 and 50 and often have symptoms such as progressive atrophy of the muscles of the limbs, weakness, and respiratory failure.

In addition, in the early stage, it is easy to have difficulties in swallowing and speaking.

So, what causes patients to get ALS?

2. Causes of ALS.

Now, there is no correct conclusion about the cause of ALS. However, the following factors are thought to be involved in the occurrence of ALS.

Bad lifestyle habits, long-term smoking, etc.

Exposure to pesticides, lead, organic poisons, electromagnetic radiation, etc.

Abnormal metabolism of neuronal proteins and neuronal microfilaments, etc.

So, what can we do with this type of disease like ALS?

3. What should ALS do**?

Because ALS is a special disease, there are mainly the following methods.

1) Medications**.

Commonly used drugs: cresol tablets, ropivacaine hydrochloride tablets, etc.

Meconazole tablets. Imidazole tablets are a drug that can delay the development of ALS, has the effect of reducing excitatory transmitter toxicity, and can be used to increase cell survival through the blood-brain barrier, suitable for ALS patients**.

Ropivacaine hydrochloride tablets.

Ropivacaine hydrochloride tablets, the main ingredient is ropivacaine hydrochloride, which is a relaxant of central skeletal muscle, with a variety of pharmacological effects, acting on vascular smooth muscle, playing a role in dilating blood vessels and increasing blood flow, suitable for improving the flexibility of the patient's limbs, but not reducing muscle strength.

2) Breathing**.

On the other hand, respiration** in patients with ALS can be aided by general oxygen and dual positive pressure ventilators when the patient has symptoms of dyspnea. If the condition deteriorates further and there is respiratory failure, it is necessary to immediately cut the trachea and use an artificial ventilator.

Finally, Xiaokang will explain to you again. Here are some frequently asked questions about ALS.

Fourth, the answers to common doubts.

1. What are the contraindications for ALS patients?

In terms of diet, it is necessary to avoid chicken essence and miso soup.

It is necessary to prohibit the preamble in terms of living habits.

Patients with ALS should not be exposed to pesticides, lead, organic poisons, electromagnetic radiation, etc.

2. Is ALS complete?

According to current medical technology, ALS is not yet possible. On the other hand, taking imidazole tablets can only prolong the survival time of patients to a certain extent, and it is also helpful to delay the progression of the disease, which can give patients a longer time and better quality of survival.

Amyotrophic lateral sclerosis (ALS) is also known as motor neuron disease (MND), the latter name is commonly used in the United Kingdom, Charcot disease in France, and Lou Gehrig disease in the United States. In China, amyotrophic lateral sclerosis and motor neuron disease are commonly mixed. It is caused by damage to the upper and lower motor neurons, resulting in gradual weakness and atrophy of the muscles including the bulbar (the bulbar refers to the part of the muscles innervated by the medulla), limbs, trunk, chest and abdomen.

Motor neurone disease is commonly known as ALS, and the more famous person is Stephen Hawking. Motor neuron disease only invades the motor system, it can invade the pyramidal cells of the cerebral cortex, the corticospinal tract, the motor nerve cells of the brainstem, and the anterior horn cells of the spinal cord, so it mainly invades the motor system and the sensory system is not affected.