How is ALS caused?What causes ALS?

1.Heredity. If someone in the family has the disease, the chances of the offspring will also be higher. Mainly because the dominant gene has a relatively strong hereditary nature, there will be a certain chance of developing this disease.

2.Toxin accumulation.

When neurotoxins accumulate continuously, glutamate is caused.

It accumulates between nerve cells, and over time, there is a high possibility of causing damage to nerve cells, which will cause this disease. For example, aluminium poisoning can lead to ALS.

3.Genetic defects.

If there is a genetic defect in the body during the fetal period, it may lead to some kind of neurodysplasia in the body, and the patient is free radicals.

Make nerve cell membranes.

There is a certain amount of damage, so there is a certain possibility of ALS.

Second, ALS.

1.Take it like a lot.

At present, the more effective drug for ALS is Lirutai, which must be used at the onset of the disease, and the sooner it is used, the better the effect.

2.Take neurotrophic factors as well as antioxidants.

During the period of taking drugs**, it is also necessary to use certain adjuvant drugs**, and neurotrophic factors and antioxidants are better adjuvant drugs. Examples include vitamin E, vitamin C, and creatine.

Wait. 3.Oxygen**.

If the disease causes the respiratory system.

If there is a certain disorder, oxygen or a dual positive pressure ventilator can be used to help the patient breathe.

3. Nursing care of ALS patients.

1.Eat a balanced diet.

When ALS patients are able to eat normally, they must eat a balanced diet and eat more high-protein.

High-calorie foods that can help the body consume nutrients.

2.Eat more liquid foods.

If the patient has difficulty swallowing and other problems, he or she can choose to eat semi-liquid or soft food.

The causes of ALS are as follows:

1. Infection and immune factors, this factor is the main cause of this disease, and the occurrence of this disease is related to virus administration and human immunodeficiency virus.

2. Metal elements, the occurrence of this disease is related to some metal poisoning or the lack of certain elements, and the overall difference in the content of metal elements in the environment is the main reason for the geographical high incidence of ALS in some areas.

3. Genetic factors, the disease has a strong hereditary nature, most patients have a family history, the main way of inheritance is chromosomal dominant inheritance, the most common pathogenic gene is copper superoxidase.

4. Nutritional disorders, some patients will have different degrees of ALS after gastrectomy, so the appearance of this disease is related to nutritional disorders.

5. Neurotransmitters and excitatory amino acids have a certain degree of neurocytotoxicity, and if the substance exceeds the standard in the body, it will lead to ALS.

The cause of ALS is determined based on the currently known data. First of all, about 5% of patients are caused by genetic factors. Second, it is related to genetic mutations.

Third, it is associated with infections, including enteroviruses, polioviruses, etc., which can cause damage to the anterior horn motor horm in the human body, leading to its death. Fourth, it is related to heavy metal pollution.

ALS is a neurodegenerative disease that occurs in middle-aged and elderly people aged 40 to 70, and the onset is mostly insidious and progressive. The symptoms are: the muscles are gradually unable to move, as if they are frozen, and gradually appear limb weakness, muscle tremors, and slowly progress to muscle atrophy, dysphagia and even respiratory failure.

Generally speaking, it takes about three to five years from the onset of symptoms to the time when the whole body is frozen, and the induced mortality rate is 90% within five years.

ALS is known as one of the world's five major terminal diseases, and it is currently unavailable. Through research, it has been found that the main causes of ALS are as follows:

Familial inheritance. In ALS, only 5%-10% are familial, and the inheritance mode is mainly autosomal significant. Have a clear genetic background; Between 90% and 95% of patients have no family history. In patients with a family history and some without a family history, the disease is associated with genetic mutations, and the most common causative gene is the copper zinc superoxide dismutase gene.

About 20% of familial and 2% of sporadic amyotrophic lateral sclerosis are associated with mutations in this gene. Gene mutations that have been identified include SOD1, TarDBP, Fus, OPTN, Ang, UBQLN2, C9orF72, etc.

Immune factors. Clinical examination often reveals abnormal immune function, and abnormal amounts of immune complexes and immunoglobulins are found in the body.

Trauma may lead to nerve damage after trauma, and then the corresponding symptoms appear, and most patients with motor neuron disease have a history of trauma of varying degrees.

Excessive physical exertion.

Some data show that heavy manual workers such as miners and construction workers have a greater chance of suffering from motor neuron disease, because through excessive physical labor, many metabolites in the body cannot be excreted from the body in time, and the functional metabolism of nerves will also be damaged to varying degrees.

Environmental factors. Environmental factors may also play a role in the onset of ALS, some scholars believe that the onset of ALS may be related to certain metals, such as lead, mercury, aluminum, etc., and some evidence suggests that exposure to lead or other substances in the workplace or at home may be related to ALS.

Although ALS is not currently available, it can improve symptoms, improve quality of life, and delay disease progression. For example, some physical** help maintain coughing, swallowing, and speaking function in patients with symptoms of weakness; If symptoms such as muscle stiffness, spasms, convulsions, salivation, excessive saliva, and mood swings occur, relevant drugs can be given to improve the patient's symptoms; If breathing is difficult, a breathing apparatus can help the person breathe. Some medications, taken under the guidance of a doctor, can slow the progression of the disease; The most important thing is to maintain an optimistic attitude, which can help to manage the condition.

To prevent ALS, experts remind you to avoid exposure to toxic substances as much as possible, develop good hygiene habits, establish a healthy lifestyle, exercise more, and maintain physical and mental health.

ALS, also known as amyotrophic lateral sclerosis, is a rare neurodegenerative disease, in which patients mainly manifest as weakness, atrophy, and bulbar paralysis of skeletal muscles, and its causes are several ways:

1. Immune factors, clinical examination often finds that the patient's immune function is abnormal, and the number of immune complexes and immunoglobulins in the body is abnormal.

2. Deficiency of trace elements, such as metal elements and other trace elements, is a phenomenon found in patients with ALS.

3. Genetic factors, according to clinical investigations, ALS is an autosomal inherited disease, and there may be a 5%-10% chance of being passed on to the next generation according to the difference between dominant and recessive genes.

ALS, also known as motor neuron disease, has an insidious onset and mild early symptoms, often confused with the general manifestations of other diseases. In the early stage of the disease, patients often have only one arm or one leg weakness, or the voice is slurred or speech is slow, the body is easily fatigued, the muscles beat involuntarily, muscle pain, and the mood is easy to change, and gradually progresses to muscle atrophy and difficulty swallowing, difficulty speaking, choking on eating, and finally respiratory failure, and generally no sensory impairment.

ALS is also known as amyotrophic lateral sclerosis. It is the most common type of motor neuron disease. Both upper and lower neurons are compromised, with muscle weakness, muscle atrophy, and significant vertebral tract signs.

The most common first symptom is clumsiness and weakness of one or both fingers, followed by atrophy of the small muscles of the hand, which gradually extend to the forearm, upper arm, and shoulder girdle muscles.

Mixed form of upper and lower motor neuron disease. Usually the first symptom is hand muscle weakness and atrophy, which generally starts from one side and then spreads to the opposite side, and with the development of the disease, there are mixed symptoms of upper and lower motor neuron damage, which is called amyotrophic lateral sclerosis. In the late stage of the disease, the muscles of the whole body are emaciated and atrophied, so that they cannot raise their heads, have difficulty breathing, and are bedridden.

The disease usually occurs between the ages of 40 and 60, and about 5 to 10% have a family history, and the course of the disease varies in speed and progression.

The answer is that it is not completely**, and it can only prolong the survival time of patients and delay the disease by taking riluzole tablets.

The famous physicist Stephen Hawking believes that everyone does not know. In addition to his legendary research results, his physical immobility was a matter of concern.

1. What kind of disease is ALS?

ALS, also known as neuronal motility, mainly refers to the gradual weakening and atrophy of muscles such as the ball, limbs, trunk, chest and abdomen after the upper and lower motor neurons of our body are damaged.

On the other hand, patients with ALS are mainly men between the ages of 40 and 50 and often have symptoms such as progressive atrophy of the muscles of the limbs, weakness, and respiratory failure.

In addition, in the early stage, it is easy to have difficulties in swallowing and speaking.

So, what causes patients to get ALS?

2. Causes of ALS.

Now, there is no correct conclusion about the cause of ALS. However, the following factors are thought to be involved in the occurrence of ALS.

Bad lifestyle habits, long-term smoking, etc.

Exposure to pesticides, lead, organic poisons, electromagnetic radiation, etc.

Abnormal metabolism of neuronal proteins and neuronal microfilaments, etc.

So, what can we do with this type of disease like ALS?

3. What should ALS do**?

Because ALS is a special disease, there are mainly the following methods.

1) Medications**.

Commonly used drugs: cresol tablets, ropivacaine hydrochloride tablets, etc.

Meconazole tablets. Imidazole tablets are a drug that can delay the development of ALS, has the effect of reducing excitatory transmitter toxicity, and can be used to increase cell survival through the blood-brain barrier, suitable for ALS patients**.

Ropivacaine hydrochloride tablets.

Ropivacaine hydrochloride tablets, the main ingredient is ropivacaine hydrochloride, which is a relaxant of central skeletal muscle, with a variety of pharmacological effects, acting on vascular smooth muscle, playing a role in dilating blood vessels and increasing blood flow, suitable for improving the flexibility of the patient's limbs, but not reducing muscle strength.

2) Breathing**.

On the other hand, respiration** in patients with ALS can be aided by general oxygen and dual positive pressure ventilators when the patient has symptoms of dyspnea. If the condition deteriorates further and there is respiratory failure, it is necessary to immediately cut the trachea and use an artificial ventilator.

Finally, Xiaokang will explain to you again. Here are some frequently asked questions about ALS.

Fourth, the answers to common doubts.

1. What are the contraindications for ALS patients?

In terms of diet, it is necessary to avoid chicken essence and miso soup.

It is necessary to prohibit the preamble in terms of living habits.

Patients with ALS should not be exposed to pesticides, lead, organic poisons, electromagnetic radiation, etc.

2. Is ALS complete?

According to current medical technology, ALS is not yet possible. On the other hand, taking imidazole tablets can only prolong the survival time of patients to a certain extent, and it is also helpful to delay the progression of the disease, which can give patients a longer time and better quality of survival.

Amyotrophic lateral sclerosis (ALS) is also known as motor neuron disease (MND), the latter name is commonly used in the United Kingdom, Charcot disease in France, and Lou Gehrig disease in the United States. In China, amyotrophic lateral sclerosis and motor neuron disease are commonly mixed. It is caused by damage to the upper and lower motor neurons, resulting in gradual weakness and atrophy of the muscles including the bulbar (the bulbar refers to the part of the muscles innervated by the medulla), limbs, trunk, chest and abdomen.

Motor neurone disease is commonly known as ALS, and the more famous person is Stephen Hawking. Motor neuron disease only invades the motor system, it can invade the pyramidal cells of the cerebral cortex, the corticospinal tract, the motor nerve cells of the brainstem, and the anterior horn cells of the spinal cord, so it mainly invades the motor system and the sensory system is not affected.