What are the symptoms of hyperammonemia?

Hyperammonemia is caused by disorders that severely impede ammonia metabolism and is common in liver failure due to severe liver disease. Blood ammonia is produced by the metabolism of amino acids in the human body. Ammonia is a toxic substance, but it is relieved of toxicity by synthesizing urea after hepatic urea synthase.

If the biotin in the body is insufficient, the enzyme activity decreases, and the ammonia cannot be metabolized smoothly, which can cause hyperammonemia.

How is hyperammonemia**?

First of all, the main measure is to limit protein intake, use other metabolic pathways to increase ammonia excretion, and supply the nutrients that are lacking. The supply of protein is limited to 2 grams per kilogram per day in infancy, grams per kilogram per day in early childhood, and about one gram per kilogram per day in childhood. Measuring blood ammonia and blood glutamine levels at the same time can help determine the appropriate protein intake.

The second aspect is to promote the excretion of ammonia, and its common adverse reactions are nausea and vomiting. <>

What are the symptoms of hyperammonemia?

Refers to the concentration of ammonia in the blood beyond the normal range, and the increase in blood ammonia can cause central nervous system symptoms. Because the elevated blood ammonia will have an obvious toxic effect on the central nervous system of the human body, patients often manifest as apathy, depression, apathy, consciousness disorder, coma, lethargy, disorientation, etc., if it is caused by liver disease, the patient will also be accompanied by primary symptoms, such as abdominal pain, bloating, indigestion, abdominal pain, weight loss, night sweats, jaundice, etc. <>

How is hyperammonemia caused?

It is usually because the liver is unable to carry out normal detoxification. After ammonia enters the liver, urea is synthesized in the liver and excreted with the kidneys. When the liver is damaged, it cannot be metabolized normally, and blood ammonia rises.

There is also a physiological condition of elevated blood ammonia, which is caused by taking too much high-protein food and excessive exercise, which can be relieved by adjusting the diet structure and paying attention to rest. Another reason is that the enzyme activity in the body is reduced, and the metabolism of amino acids is insufficient, resulting in an increase in blood ammonia. Ammonia is mainly metabolized in the liver through urea.

In general, when there is a problem with the liver, the blood ammonia will be elevated. <>

The mood fluctuations are particularly large, and you will feel very happy, but sometimes you will be easily angry, you will vomit when you eat some protein foods, you will often want to sleep, and sometimes you will fall into a coma.

The mood is very irritable, or the expression is particularly excited, and there will be tremors when slapping the body, and in severe cases, there will be loss of consciousness.

The symptoms of this disease are dizziness, nausea, diarrhea, mental malaise, physical weakness, drowsiness, and reduced diet.

Hyperammonemia is a genetic disorder. Children with this disorder may experience lack of energy. Have severe liver disease and cause hepatic encephalopathy, resulting in syncope.

The mood is not very stable, there will be some syncope, or there is vomiting, I want to sleep very much, and sometimes I will be short of breath.

Hyperammonemia is mainly a disease caused by elevated ammonia levels in the blood, and in severe cases, it can lead to cerebral edema and intracranial hypertension, which seriously affects physical health. The symptoms of hyperammonemia are divided into acute hyperammonemia and chronic hyperammonemia, and the acute and chronic symptoms are different.

1. Symptoms of hyperammonemia.

1.Acute hyperammonemia can cause symptoms such as mental abnormalities, drowsiness, coma, vomiting, convulsions, and cerebral edema, and newborns may have symptoms such as shock and respiratory failure.

2.Chronic hyperammonemia includes anorexia, headache, dizziness, tremors, fatigue, aggressive or self-injurious behavior, cognitive impairment, inadequate learning ability, failure to thrive, elevated liver enzymes, psychiatric symptoms, etc. and intermittent seizures.

3.Hyperammonemia can also lead to complications such as hepatic encephalopathy, respiratory alkalosis, and dyspnea.

2. Causes of hyperammonemia.

There are two causes of hyperammonemia, one is primary hyperammonemia, which is genetic; One is secondary hyperammonemia, which is caused by the accumulation of some compounds in the body due to abnormal metabolism outside the urea cycle, which inhibits the enzymes in the urea cycle or causes a deficiency of metabolites required for the urea cycle, thereby affecting the progress of the urea cycle.

3. Hyperammonemia.

Hyperammonemia is generally treated by intravenous infusion**, and if necessary, medications**, and when using drugs, they must be used under the guidance of a doctor to avoid adverse effects. Hyperammonemia can also be managed by diet. In daily life, it is recommended to eat a regular diet, eat more nutritious foods, eat less foods with high protein content, and eat sugary and starchy foods in moderation.

You can eat more vitamin and dietary fiber foods, eat more vegetables and fruits, etc., which not only helps to prevent constipation, but also meets the nutritional needs of the body, which is very helpful for the recovery of the condition.

In addition, it is necessary to pay attention to rest, ensure sleep, keep the environment quiet and comfortable, etc. It is necessary to care more about and encourage the patient to maintain a happy mood to avoid self-injurious behavior.

The symptoms of hyperammonemia are restlessness, nausea and vomiting, drowsiness, and mental retardation. What I understand is that the rate of this disease is relatively high, and the process of the disease is more complicated, which will cost a lot of money, and the process is more painful.

There will be symptoms of weakness in the limbs, symptoms of hotheadedness, symptoms of dizziness, symptoms of loss of appetite, and symptoms of indigestion. So when we have this situation, we must go to the hospital for a physical examination, and don't let the condition worsen.

May affect liver function, may lead to cirrhosis, may get hepatitis, often irritable. Emotional instability may occur.

It is mainly a symptom of hepatic encephalopathy caused by cirrhosis of the liver, and you can take Chinese patent medicine to reduce the intake of amino acids, fats, and cholesterol.

You may not want to eat, you may want to sleep often, you may have convulsions, your body temperature will drop, and your arms may go numb. It's still very scary, and if something uncomfortable appears, you must see a doctor as soon as possible.

Hyperammonemia is caused by a serious disorder of ammonia metabolism, hyperammonia is an important cause of hepatic encephalopathy, and the early manifestations will have excitement, irritability, personality changes, etc., and the symptoms can be improved by early and standardized.

Vomiting, refusal to eat, drowsiness, confusion, anxiety, irritability, ataxia, and deep coma may occur, as well as aggressive behavior. I think if you have such symptoms, you must go to the hospital for a check-up in time.

It is that you will find that you don't want to eat, vomit, and then have symptoms of drowsiness and coma, in fact, there is still damage to the body, and you need to go to the hospital for examination in time, so as to facilitate it as soon as possible**.

What should I do if the blood ammonia grade is high in patients with liver disease? Socks potato.

Analysis: According to your child's condition, it is likely to be liver damage caused by pathological yellow bile, which requires hospitalization**, and the normal blood ammonia value is generally 22 44 mol L, which is 4 times higher for your baby.

Guidance: If you are not hospitalized in time**, I am afraid that it is easy to get sequelae, you really need to be taken seriously, I don't know if the pediatrician said so. If you believe me, take your baby to the pediatric doctor as soon as possible. I'm in a hurry. Alas.

Analysis: Patient's age: 100 days.

Patient gender: Female.

All symptoms: blood ammonia up to 200; The smell of urine is unpleasant.

Time and cause of onset: Unknown.

Guidance: Condition Analysis:

Patient age: 100 days.

Patient gender: Female.

All symptoms: blood ammonia up to 200; The smell of urine is unpleasant.

Time and cause of onset: Unknown.

Refers to Kaiheng Zen guide's opinion:

Analysis: Patient's age: 100 days.

Patient gender: Female.

All symptoms: blood ammonia up to 200; The smell of urine is unpleasant.

Time and cause of onset: Unknown.

Guidance: Condition Analysis:

Patient's age: 100 days.

Patient gender: Female.

All symptoms: blood ammonia up to 200; The smell of urine is unpleasant.

Time and cause of onset: Unknown.

Guidance: Condition Analysis:

Patient age: 100 days.

Patient gender: Female.

All symptoms: blood ammonia up to 200; The smell of urine is unpleasant.

Time and cause of onset: Unknown.

Guidance: For such a young baby, it is better to find out the cause first, reduce protein intake, and use water or acid enema.

Analysis: Hello.

It is best to take your baby to the children's hospital for a check-up consultation.

Guidance: For hereditary hyperammonemia, the severity of its clinical symptoms is parallel to the degree of enzyme activity deficiency, that is, the more severe the enzyme deficiency, the earlier the onset of the disease, the more severe the symptoms. In the neonatal period, signs and symptoms are closely related to brain dysfunction, usually normal at birth, but symptoms develop a few days later after feeding a protein-containing diet (eg, breast milk), such as food refusal, vomiting, shortness of breath, lethargy, and soon into a deep coma, often with convulsive seizures.

Analysis: According to your description, it is mainly caused by the fact that the child is still young, the function of various organs is not perfect, and the blood ammonia metabolism is slow.

Guidance: There is no need to worry about this situation, it can also be said to be a physiological condition, and it will be fine after a while.

Simply elevated blood ammonia is of little significance, and if there are other symptoms, it is necessary to be alert to hepatic encephalopathy.

The construction and reform of the hospital was proposed to go to the hospital to do a liver fibrillation spinal function test, and after the diagnosis, the right medicine was prescribed.

Analysis: Hello, do you have to check the baby's kidney function? If the blood ammonia sail is high, it may be the reason why the kidneys are not excreted.

Counseling fiber or: Hello, it is recommended that you check the kidney function of your baby, and there will generally be this result in the results of blood biochemistry. Look at your baby's condition based on kidney function.

The main symptoms of hyperammonemia:

High blood ammonia is when the blood ammonia concentration is above the normal range. When blood ammonia rises, it tends to cause two symptoms in the body. The first category is central nervous system symptoms.

Because after the blood ammonia rises, it will have obvious toxic effects on the central nervous system of the human body. Patients often present with apathy and depression, and in severe cases, hepatic encephalopathy such as mania and coma. The second category, the symptoms of the primary disease, the most common of which are the symptoms of various liver diseases, because the most common causes of elevated blood ammonia are various liver diseases, such as hepatitis B cirrhosis, liver cancer, liver necrosis, and so on.

These diseases can exhibit different symptoms depending on the type of disease. For example, liver cancer patients will experience a series of symptoms such as abdominal pain, bloating, yellowing of the sclera, weight loss, and night sweats. So there are two kinds of symptoms of elevated blood ammonia, one is neurological symptoms, and the other is the primary symptom.

Hyperammonemia**:

First of all, the main ** measure is to limit protein intake and use other metabolic pathways to increase ammonia excretion, thereby supplementing insufficient nutrients. The amount of protein is up to 2 g kg in infancy, up to 1 g kg in infancy, and 1 g kg in childhood. At the same time, measuring blood ammonia and blood glutamine levels can help determine whether protein intake is appropriate.

Extended information: Hyperammonemia is a clinical syndrome characterized by abnormally elevated blood ammonia levels and central nervous system dysfunction. Due to its low incidence and lack of specificity in clinical manifestations, it is easy to cause misdiagnosis and missed diagnosis, and some patients cannot be correctly diagnosed until clinical death.

The protein that the body consumes every day is digested and broken down in the intestines to produce a certain amount of ammonia. Ammonia is a toxic substance that is synthesized by urea synthase in the liver to relieve toxicity. The urea synthase required for this process contains biotin, and if the biotin in the body is insufficient, the enzyme activity decreases, and ammonia cannot be metabolized smoothly, which may cause hyperammonemia.

The main symptom is that the patient will be in a coma, and will feel particularly irritable, depressed, and there will be some conditions in the liver, and there will be frequent sweating, which can only be done through surgery at the time.

When the blood ammonia is high, it will cause patients to have central nervous system symptoms, usually patients have apathy, consciousness disorders, coma, lethargy, disorientation, etc., if it is caused by liver disease, patients will also be accompanied by primary symptoms, such as abdominal pain, bloating, indigestion, abdominal pain, weight loss, night sweats, jaundice, etc.

People with high blood ammonia do not eat much meat, legumes, and can eat fish. In severe cases, it is required**, and drugs to protect the liver are required**. The cause of hyperammonemia is related to the lack of enzyme activity related to the urea cycle, which may cause cerebral atrophy and severe damage to liver function.

High blood ammonia and low protein are the manifestations of liver damage, and there is very little blood ammonia reduction in diet, mainly to restore liver function.

If the blood ammonia is high, you should take some drugs to lower blood ammonia, especially pay attention to the smoothness of the stool, if the stool is not smooth, the blood ammonia is easy to increase.