The virus has mutated, is the vaccine no longer working?

Where is the region that needs to mutate the virus in the genome?

The development of the vaccine is based on the protein encoded by the immunogenicity of the new coronavirus, which is the surface protein of the new coronavirus.

If the region in which the virus mutates is the coding region of the surface protein, the vaccine may not be effective; If the virus mutates in other regions of the genome, non-surface protein-coding regions, the vaccine is still effective.

How? In layman's terms, the vaccine itself is a component of the virus created by humans, which is used to allow the immune system to train its "target" in advance, so as to attack the virus when it is actually infected. Think of the vaccine as the "vest" of the virus, and the immune system sees the horse as the virus.

When the virus mutates, if the vest is not changed, the human immune system still recognizes the vest and will attack the virus, and the vaccine will still be effective; If the vest is changed after the virus mutates, the immune system will not recognize it. Vaccines don't work.

Logically so, it is also the result of natural selection of Yukiki.

Not necessarily, according to the law of communication, as long as the incubation period is long enough to complete the transmission, it will not disappear soon, the situation in nature cannot be compared with humans, the rabbits in Australia are infected with a virus, 99% of them die, and then the virus mutates, and the rabbits return to the population, can human society die 99% to achieve the result of natural selection?

It's the so-called herd immunity, and if I explain it this way, you should understand the nonsense of herd immunity!

The mutation of the virus is not only two dimensions, but several dimensions, infectivity, lethality, incubation period, and so on. Life is better than death for the virus, it's the same, the host is alive, the virus has no IQ, it will only mutate in all directions, who knows what it will become, mutating into a zombie virus is also a direction, destroying the brain but the person is not dead, can you accept it?

The vaccine is still effective.

It is also effective for variants.

Many citizens feel that the new crown virus has been mutating, and there is no need to get vaccinated at all, but I don't think so, vaccination is to improve the body's antibodies, but also to let everyone after accidentally diagnosed, physical fitness can be improved, not so uncomfortable. In the outbreak of the epidemic in Shanghai in 2022, many seriously ill patients have been vaccinated, and it can also be seen that not being vaccinated will indeed have a very big impact on their bodies.

Since the country has asked everyone to get vaccinated, it must be because this new crown vaccine has great benefits for our body. The new crown vaccine also has the effect of weakening the activity of the virus, which allows us to recover faster after being infected with the virus, and will not have too much impact on the body, and will not have too many complications or sequelae. The new crown vaccine has already begun to be vaccinated, and the third shot has already been completed, if you have not yet received the new crown vaccine, it is best to get vaccinated as soon as possible, so as to protect your health.

However, in life, there are some people whose physical conditions are relatively special, so here, it is also recommended that everyone decide whether to get vaccinated according to their physical conditions. If you have some rashes or other conditions, then you may not be able to get vaccinated, and you also need to talk to the doctor about some diseases in your body when you get vaccinated.

When the epidemic is more serious, your area will definitely call ** to urge you to get vaccinated. Generally, it doesn't matter when the new coronavirus is not so serious, but there are many places that you may not be able to enter if you are not vaccinated. Vaccination against the new crown must have certain benefits, and everyone should not be afraid, because many people in the country have been vaccinated with this vaccine, and there have been no deaths from vaccination.

Vaccination is still necessary, because even if the virus is mutating, its basis is still the coronavirus, and the vaccine has a certain effect on the same type.

There is no need to vaccinate again, if it mutates, it will not work, it will not produce specific antibodies, and if it has no effect, do not be vaccinated again.

There is no official statement that the vaccine is not effective against mutated viruses, but it is still effective against non-mutated ones, so it should be vaccinated.

The coronavirus has mutated in the UK and new in South Africa. Therefore, it can be seen that, in fact, the new crown virus has always mutated. If the new coronavirus continues to mutate, there may be many unexpected scenarios.

Therefore, in fact, this is a new damage to mankind, which deserves our great attention.

The mutation of the virus will be completely killed after all, and if the mutation of the new crown virus is beyond the fantasy speed of our human beings, then it will be difficult for us to control it. However, if the mutation of the new crown virus only shows a mutation in the speed of transmission, then the new crown virus itself has not changed much, and I personally believe that the new crown virus vaccine can also control it. Because, after it mutated, it was still the new coronavirus.

Therefore, its roots have not mutated, so it is completely able to manipulate it through the injection and inoculation of the new coronavirus vaccine.

Of course, if the current coronavirus vaccines cannot be manipulated, then time is a race against the mutation of the new coronavirus, which is an extremely risky job. If the current new coronavirus vaccine can manipulate it, then I personally believe that the mutation of the new crown virus will be completely killed after all. The virus has always mutated, because the new coronavirus is a single-stranded RNA virus, which is different from double-stranded DNA, and does not have its own error correction mechanism, so every time it imitates itself, it almost makes mistakes, which is what we call "mutation".

Small mutations of the virus do not affect the antigenicity of the virus, so even if the new coronavirus presents a large mutation, the mutated virus antigen can be embedded in the existing vaccine production chainRapid production of new vaccines such as "bivalent" and "trivalent" that can resist mutant viruses. No matter how the virus mutates, protect ourselves, wear masks in crowded places, wash hands frequently, adhere to hygiene and safety, and we will not be infected.

Viral drug resistance <>

If the virus mutates, the current successful development of vaccines will not be very effective, for example, a drug in patients will have a certain effect at the beginning and can achieve the expected effectIf you use this medicine for a long time, the effect will gradually deteriorate or even no effect, this is what people call virus drug resistance, because the virus also changes with the individual, temperature, environment, toxicity, etc., it is the same as biology to adapt to the livelihood with the change of various external factors and mutate to better suit their own livelihood.

Shao, a researcher at the Chinese Center for Disease Control and Prevention and an advisor to the WHO Vaccine Committee: From our current point of view, it's usually 28 days after we get the vaccine, i.e. 0 weeks, 2 weeks, 3 weeks, and 4 weeks. A single inoculation can produce a strong antibody like two shots, which can have a protective effect.

But because we are now using this vaccine on an emergency basis, we have urgently started research and conducting clinical trials. The current protective data for the longest period of observation is based on antibody levels about two months after vaccination.

Will the COVID mutation affect the protective effect of the vaccine?

Recently, there have been frequent reports of mutations in the new coronavirus. COVID is a ribonucleic acid virus. RNA viruses are less stable than DNA viruses, and viral mutations are a common problem.

Will virus mutations affect the protective effect of COVID vaccines? Experts explain that there is no evidence that this mutation would render existing vaccines ineffective.

Shao, a researcher at the Chinese Center for Disease Control and Prevention and an advisor to the Vaccine Committee of the World Health Organization: Although we have seen a lot of reports about this virus, it is also a variant from the United Kingdom, a variant from South Africa, and a variant from Europe. This refers to the first layer.

We can see that viruses are genetically changing, which is convenient for us to track in molecular epidemiology, but not as rapidly as in immunology, that is, the current mutations of these viruses, the emergence of variants, and the existing ones that we have.

How long is the COVID vaccine protection? Is the term of protection only half a year? What if COVID mutates? Chinese disease control experts responded: After a half-year protection period, there will still be a certain degree of efficacy, and the vaccine will still have a certain protective effect on the existing mutants.

Shao, a researcher at the Chinese Center for Disease Control and Prevention, said that the so-called half-year protection period only refers to the low neutralizing antibodies of some people after half a year, and if they are infected by the virus, a large number of memory cells will wake up and produce immunity. "It's not the same as the immunity of people who haven't been vaccinated. ”

Feng Zijian, a researcher and deputy director of the Chinese Center for Disease Control and Prevention, said that at present, our data on the shelf life and durability of vaccines are not sufficient, because it takes about half a year from vaccine trials to marketing, and we have not been observing for a long time. "Judging from the current data, the protection time of the vaccine in the Chinese market can reach at least half a year. Will it be longer?

This requires further observation. ”

In response to the mutant virus, Shao responded that the existing mutant strains can only partially reduce the protective efficiency of vaccines. "The decrease in protection efficiency we see is generally for mild cases, and the protection efficiency is still relatively high for severe cases. ”

On January 14, 2021, the World Health Organization's COVID-19 Emergency Committee also discussed the impact of the new variant on epidemic prevention and control, calling on countries to strengthen cooperation and share information on variants to better understand the virus variants.

Of course it worked. Experts say that no matter what the virus becomes, this vaccine is still very effective, as long as you get vaccinated on time, there is no need to worry so much.

It works. Dr. Wang Huaqing once said that even if the virus mutates, it will not affect our own immune function, so it is still necessary to get vaccinated in time.

This new crown vaccine can effectively prevent the new coronavirus, even if the strain mutates, but the body produces antibodies can still protect from the new crown vaccine. We should appeal to everyone to pay attention to rest, avoid overwork, eat a balanced diet, and avoid picky eaters.

It didn't work. Because the vaccine is made according to the genome of the virus, if it mutates, the antibodies will not follow the mutation, and a new vaccine is needed.

No matter how the virus mutates, it harms the body's immune function. If we use the immune function system that we humans have when they are produced, it can effectively enhance the body's immune-boosting antibodies. It makes the human body's metabolic function function run normally and makes the human body's adverse symptoms disappear.

Moreover, it can effectively prevent the body from fever and pain. It can excrete viruses that cause diseases in the body. It is highly likely that this immune function will stop the damage of the disease to humans.

Experts say that although the vaccine cannot completely resist the mutated virus, it can at least slightly reduce the replication rate of the virus and buy more time for the research of new virus vaccines.

It still works, and experts will speed up the development of new vaccines to prevent this mutated virus.

It depends on the mutation, if it is mutated for the vaccine, the probability of protection may be reduced, and the expert's explanation is also very conservative.

If the virus mutates, the previous vaccine won't work. Experts say vaccines change according to changes in the virus.

It also worked. Experts explain that there is still a role. And it won't be invalid yet.

If the virus mutates, the vaccine is useless, and each virus needs a targeted vaccine to control.

Just take the flu vaccine, brick family.

The mutated Bi Jing is in the minority. Just prevent the spread of ordinary viruses!

Wang Huaqing, chief expert of the immunization program of the Chinese Center for Disease Control and Prevention, said that the virus is one of the simplest organisms, and its proliferation depends on living cells. During the process of proliferation, the virus mutatesMost variants do not affect the pathogenicity of the virus, the sensitivity of detection reagents, and the effectiveness of vaccines

According to the latest information released by the World Health Organization, from the global surveillance of new coronavirus mutationsThere is no evidence that the virus mutates to render existing COVID vaccines ineffective

The World Health Organization's global network of COVID-19 laboratories includes a dedicated SARS-CoV-2 virus mutation and evolution working group, which is rapidly detecting new mutations of the virus and assessing their possible impact in a timely manner, which will also provide early warning and scientific analysis for the development and application of subsequent vaccines.

Vaccine R&D companies have carried out cross-neutralization ability testing and evaluation of vaccine immune sera for the currently collected domestic and foreign variants, and have not found that the neutralizing activity of China's conditionally marketed new coronavirus vaccines against variants has decreased significantly, nor has it been found to have a significant impact on the protection rate of variants, and relevant companies will continue to carry out follow-up studies.

According to the latest information released by the World Health Organization, from the global monitoring of new coronavirus mutations, there is no evidence that virus mutations will make existing new coronavirus vaccines ineffective.