Why can t I drink alcohol after taking cephalosporins?

Drinking alcohol after taking cephalosporin drugs can cause disulfiram-like reactions. The reason is that drinking something containing alcohol after the use of the drug can lead to the accumulation of acetaldehyde in the body and cause poisoning.

After alcohol enters the body, it is first oxidized to acetaldehyde by the action of "ethanol dehydrogenase" in liver cells, and acetaldehyde is oxidized into acetic acid and glyaldehyde A through the action of acetaldehyde dehydrogenase in liver cell mitochondria, and acetic acid is further metabolized into carbon dioxide and water to be excreted from the body.

In addition to cephalosporin antibiotics, there are other drugs that can also cause disulfiram-like reactions: imidazoles such as metronidazole, ornidazole, etc.; Other antibiotics such as furazolidone, ketoconazole, compound sulfamethoxazole, isoniazid, etc.;

sulfonylurea hypoglycemic drugs such as gliclazide, glipizide, etc.; Other drugs such as warfarin, torassurin, etc.

Alcohol should not be consumed during the period of taking cephalosporin antibiotics and within 7-10 days of stopping the drug, because a variety of cephalosporin antibiotics can inhibit an enzyme in the ethanol metabolism process, called acetaldehyde dehydrogenase, so that ethanol cannot be metabolized smoothly, resulting in previous accumulation, resulting in a disulfiram-like reaction. Patients present with facial flushing, bulbar conjunctival injection, headache, dizziness, abdominal pain, nausea, vomiting, and in severe cases, blood pressure drops, respiratory depression, heart failure, and even life-threatening. The severity of the reaction is directly proportional to the dose of the drug and the amount of alcohol consumed, and has little to do with what alcohol is drunk.

Disulfiram-like reactions often occur during the drug and within 7-10 days of drug withdrawal, because the drug needs to go through five half-lives to be basically cleared, and the inhibited acetaldehyde dehydrogenase takes 4-5 days to recover, so you should not drink alcohol during the period of taking cephalosporin antibiotics and within 7-10 days of stopping the drug, and you should also pay attention to avoid other alcohol-containing foods during this period, such as wine chocolate, drunk shrimp, drunk crab, etc., and do not use alcohol to take a bath.

The use of cephalosporin antibiotics with alcohol-containing beverages, drugs or foods can lead to the accumulation of acetaldehyde, a metabolite during ethanol degradation in the body, resulting in a toxic reaction of acetaldehyde, called disulfiram-like reaction. Patients present with excessive sweating, weakness of limbs, headache, facial flushing, chest tightness, cyanosis of the lips, and in severe cases, blood pressure drops, heart rate increases, and even angina, myocardial infarction, heart failure, shock, and the most serious can lead to death. The severity of the reaction is related to the dose of the drug used, the amount of alcohol consumed, and has little to do with the type of alcohol consumed.

Cephalosporin antibiotics that can cause disulfiram-like reactions, including cefoperazone, cefazoloxime, cefuroxime, cefradine, cefoxitin, cefminol, laoxycephalosporin, cefmondo, ceftriaxone, cefdinir, cefaclor, etc., are often used in the clinical process, so I hope you must pay attention to not drinking alcohol within seven days of taking cephalosporins and stopping the drug.

<> cefoperazone. Not all cephalosporins should not drink alcohol, only if the cephalosporin structure contains tetrazolium methyl (disulfiram), tetrazolium methyl is an acetaldehyde dehydrogenase inhibitor that inhibits the metabolism of ethanol in the body and causes acetaldehyde accumulation (red-faced asthma), in addition to cefmetronidazole also contains tetrazolium methyl group can not be drunk.

Because some cephalosporins can inhibit the acetaldehyde dehydrogenase in the liver and block the further conversion of acetaldehyde to a calculation, so that acetaldehyde accumulates in the human body and causes toxic reactions. The drugs that are most likely to cause this reaction are cephalosporins and immidas, which can induce acute liver damage, myocardial infarction, acute heart failure, respiratory failure and even death in severe cases.

Note!! During the period of taking this type of medicine, it is necessary not only to abstain from drinking all kinds of alcohol, but also to avoid all kinds of foods and drugs containing ethanol, such as rice wine, wine chocolate, etc., and the ban can only be lifted after 1-2 weeks after taking the drug!

You can't drink alcohol after taking cephalosporins, because if you drink a drug that has taken a cephalosporin, a disulfide-like reaction may occur between the drug and the alcohol. After the reaction, symptoms such as abdominal pain, nausea, vomiting, dizziness, headache, facial flushing, and palpitations may occur, and in severe cases, life may be in danger. People who don't drink alcohol or who drink a small amount of alcohol have a more severe reaction.

After oral cephalosporins, you should not drink alcohol for a week, not only should you not drink alcohol, but you should also not eat drugs containing alcohol and foods, such as chocolate, to avoid adverse reactions.

Because drinking alcohol and eating cephalosporin will kill people, and chemical reactions will occur.

Cephalosporin antibiotics can trigger a disulfiram-like reaction when met with alcohol, resulting in a series of symptoms such as chest tightness, shortness of breath, facial flushing, redness and swelling, headache and nausea, which may be life-threatening in severe cases.

There is a conflict between the two eating together.

Cold medicines, anti-inflammatory drugs, antibiotic drugs, antihypertensive drugs, hypolipidemic drugs, etc., these medicines are not allowed to drink alcohol after eating, otherwise adverse reactions will occur.

You can't eat cephalosporin after drinking, because there will be a lot of alcohol in the body, alcohol can have many adverse chemical reactions with cephalosporin, and rash may occur, **itching, severe will lead to breathing difficulties, and even loss of life, you can't take cold medicine, antihypertensive drugs, hypoglycemic drugs, or antibacterial and anti-inflammatory drugs after drinking.

Why can't you eat cephalosporin after drinking?

Cephalosporin cannot be consumed with alcohol, and cephalosporin inhibits the metabolism of alcohol, which is metabolized in the liver, producing acetaldehyde and accumulating in the body, resulting in adverse reactions similar to disulfiram. Adverse physical symptoms include flushing, rapid heartbeat, shortness of breath, vomiting, and in severe cases, death.

When the patient is sick, drinking alcohol is not conducive to the recovery of the condition, so when taking cephalosporin, do not drink alcohol, the reaction is very strong, if you accidentally take cephalosporin after drinking, you must go to the hospital in time, do not drink alcohol during the period of taking cephalosporin, and do not use drugs containing alcohol to avoid reactions.

What other medicine can't be taken after drinking?

If you take cold medicine after drinking alcohol, it may lead to liver failure and may even lead to liver cancer. In addition, do not take antihypertensive drugs after drinking alcohol to avoid blood vessel swelling and hypotensive shock. When taking antiangina drugs, if you drink too much alcohol, it can cause blood vessels to swell, leading to headaches, sudden drops in blood pressure, difficulty breathing, and myocardial infarction.

Aspirin and ibuprofen are commonly used antipyretic and analgesic drugs, and if you drink too much alcohol after taking them, they can easily cause gastrointestinal mucosal bleeding and ulcers. Do not drink alcohol during the period of taking blood sugar control drugs, otherwise it will lead to hypoglycemia, hand tremors, palpitation, palpitation, cold sweats, etc., and even hypoglycemic shock.

It can be seen from this that taking medicine after drinking alcohol is very likely to produce chemical reactions, so try not to drink alcohol after taking medicine, the above is my problem, I hope it can help you.

Because the substances produced by the alcohol party and the cephalosporin reaction can have serious effects on the human body; Anticoagulants, hemostatic drugs, hypnotics, antihypertensive drugs, hypoglycemic drugs.

Medicines, which cannot be taken after drinking alcohol, are mainly because alcohol can interact with certain drugs, leading to drug poisoning.

1. You can't take cephalosporin antibiotics when you drink alcohol, including cefoperazone and cefazolin, so if you want to take antibiotics when you have a cold, remember not to drink alcohol;

2. Do not take hypoglycemic drugs after drinking, because alcohol will accelerate the hypoglycemic effect of hypoglycemic drugs and is prone to hypoglycemic reactions;

3. Antipyretic and analgesics, such as acetaminophen, etc.; Fourth, antihypertensive drugs can easily cause hypotension.

Drinking alcohol after taking cephalosporin drugs can cause disulfiram-like reactions. As a result, it can cause red face, red ears, fast heart rate, low blood pressure and other manifestations, and in severe cases, respiratory depression, myocardial infarction, acute heart failure, convulsions and death.

Disulfiram-like reaction can be explained by the normal alcohol metabolism pathway, alcohol, the chemical name is ethanol, after entering the body, it is first converted into acetaldehyde by the action of ethanol dehydrogenase in the liver, and then converted into acetic acid by the action of acetaldehyde dehydrogenase, and the acetic acid enters the citrate cycle, and finally converts into water and carbon dioxide for excretion.

Two enzymes in the link play an important role in alcohol metabolism. The cephalosporin antibiotics, especially the methyl thiotetrazolium group (MTT) contained in the third-generation cephalosporin antimicrobial molecule, can inhibit the activity of acetaldehyde dehydrogenase, so that the acetaldehyde cannot be degraded, resulting in acetaldehyde poisoning, which is the so-called disulfiram-like reaction.

First of all, the components in cephalosporin will react with alcohol, and patients may experience headache, dizziness, redness, nausea, vomiting, hallucinations, dyspnea and other symptoms.

Then, cephalosporin is mainly metabolized by the liver and kidneys, and eating cephalosporin after drinking alcohol will increase the burden on the liver and kidneys.

Finally, eating cephalosporin after drinking alcohol, in addition to affecting the effect of the drug, may also lead to aggravation of the disease.

After drinking alcohol, you must not take cephalosporin drugs, and you can't take some cold medicines, as well as metronidazole. These drugs will affect the metabolism of alcohol in the liver, and will lead to the accumulation of acetaldehyde in the liver, and there will be obvious clinical symptoms, such as obvious palpitations, chest tightness, palpitation, and redness.

For example, in more severe cases, there may be unstable vital signs, rapid heartbeat, decreased blood oxygen saturation, and even the risk of death in severe cases. Therefore, after drinking alcohol, you must not take cephalosporin drugs, and after taking cephalosporin drugs, you must drink alcohol for at least five days, and you must avoid these two at the same time.

I have eaten cephalosporin many times after drinking, and I don't feel any adverse reactions. But the wine I drink is usually a bottle of beer. Now there are all kinds of false rumors, and all kinds of replies on the Internet that you can't eat cephalosporin are not clear how much alcohol you will have a toxic reaction after ingestion, and they are not scientific answers.

Talking about toxicity without dosage is a hooligan.

After drinking, the reason why cephalosporin cannot be eaten is that the components in cephalosporin will react with alcohol, and patients will have headache, nausea, vomiting, and severe shock. Moreover, eating cephalosporin after drinking alcohol will increase the burden on the liver and kidneys.

This is mainly because some ingredients in cephalosporin drugs will react with alcohol and cause harm to the human body, so it is not possible to eat cephalosporin when drinking alcohol.

Because cephalosporin and alcohol cannot exist at the same time, if they are at the same time, there is a high probability that poisoning will occur.