What are the symptoms of mid to late myelofibrosis?

In the middle and advanced stages of myelofibrosis, the anemia will become more severe, and patients will experience symptoms of pallor, fatigue, weakness, shortness of breath after activity and palpitations. People with advanced myelofibrosis develop thrombocytopenia, so they often bleed and,** often have purpura or ecchymosis. Splenomegaly is evident.

There may be a feeling of tightness and distension in the upper abdomen, or the spleen may grow too quickly. Patients will have severe pain due to local splenic infarction. Hyperuricemia can also cause renal colic and gouty arthritis.

At the same time, patients with advanced myelofibrosis may also have fever, mainly due to infection. Some patients also have unexplained diarrhea. Increased metabolism can cause low-grade fever, night sweats, tachycardia, etc.

Some patients may also have an enlarged liver, which accounts for about 50% to 70%, mostly mild to moderate swelling and portal vein thrombosis. Patients with myelofibrosis may experience panic, discomfort, and pallor in the advanced stages of the disease, and may also have anemia, chest tightness, and shortness of breath. In addition, patients may also lose significant weight.

Most patients with myelofibrosis have a slow onset and may have subtle symptoms in the early stages, with more organs involved in the later stages of myelofibrosis, which manifest as gradual fatigue, weakness, emaciation, and weakness. Patients may have bone pain, arthralgia, low back pain, and renal colic. Hepatosplenomegaly causes abdominal pain and abdominal masses.

Hemorrhage, anemia, pallor and mucous membranes, shortness of breath, purpura. Patients with secondary infections develop fever. If the patient has intracranial hemorrhage, they will have a sudden headache and loss of consciousness.

Myelofibrosis is a myeloproliferative disorder caused by collagen hyperplasia in the hematopoietic tissue of the bone marrow and its fibrous tissue obstructing hematopoietic function. It is clinically characterized by juvenile erythrocytic and granulocytic anemia with teardrop-like red blood cells. Bone marrow aspirate often presents with dry pumping, splenomegaly, and varying degrees of osteosclerosis.

The prognosis for myelofibrosis is poor. At present, there is no specific drug that can completely ** it. Myelofibrosis** includes blood transfusions, platelet transfusions, and hemostasis; Erythropoietin and protein anabolic steroids are used to promote bone marrow hematopoiesis.

Patients with megasplenism and portal hypertension can undergo chemotherapy or splenectomy, oral thalidomide for immunomodulatory and antineoplastic therapy, and hematopoietic stem cell transplantation if available.

Spleen and hepatomegaly, bleeding symptoms, etc. Enlargement of the spleen and liver, you will feel a feeling of swelling in the abdomen; Bleeding symptoms, purpura and ecchymosis due to thrombocytopenia.

The symptoms are very obvious, and there will be different symptoms, the body will become thinner and thinner, and the complexion will be very poor.

Patients with myelofibrosis reach the middle or advanced stage, the symptoms are already more obvious, and the patients will have more severe anemia. Especially after outdoor activities, there will be obvious symptoms such as dizziness and physical weakness, mainly manifested by chest tightness and shortness of breath, pale complexion and other phenomena. In the advanced stage, leukemia may also be induced, so myelofibrosis appears, and it must be detected early**.

In the middle and advanced stages of myelofibrosis, the degree of anemia will become more and more severe, and the patient will have symptoms of paleness, fatigue, weakness, shortness of breath after exertion, and palpitations. Patients with advanced myelofibrosis will have thrombocytopenia, so they often have signs of bleeding and,** purpura or ecchymosis.

Splenomegaly is more obvious, there may be a feeling of fullness in the upper abdomen or the spleen enlarges too quickly, and the patient will experience severe pain due to local infarction of the spleen. Hyperuricemia can also cause renal colic and gouty arthritis.

At the same time, patients with advanced myelofibrosis can also have fever, most of which is due to infection. Some patients also have unexplained diarrhea, and increased metabolism can cause low-grade fever, night sweats, tachycardia, etc.

Some patients may also have hepatomegaly, which can account for about 50% to 70%, and most of them are mild to moderate enlargement, and portal vein thrombosis may form.

At this time, the body's immunity will be reduced, and at this time, it will be infected with a lot of viruses, and at this time, there will also be symptoms of fever. Severe anemia can also occur, and entering the advanced stage will also cause blood function failure, which will lead to hepatosplenomegaly.

The symptoms are dizziness and nausea, weakness in the limbs, chest tightness and shortness of breath, paleness, and anemia, and the resistance will get worse and worse, and the high fever will not go away, and some organs will directly fail.

Fatigue, shortness of breath after exertion, palpitations, pallor, thrombocytopenia and other symptoms are the most common symptoms.

Anemia, paleness, fatigue, bleeding from organs, indigestion, infection, and coma in severe cases.

Myelofibrosis usually has a slow onset and can have no symptoms in the early stage, and then gradually appear fatigue, night sweats, palpitation, pallor, shortness of breath and other weak symptoms, abdominal pain, abdominal mass, bone pain, jaundice, etc. Most of the disease progresses slowly, with a duration of 1 to 30 years, and some can transform into acute leukemia. A small number present with acute myelofibrosis, which is short and dangerous, and more than 1 year of death.

The main manifestations are:

1.Gradual onset of fatigue, weakness, emaciation, and weakness.

2.**Pale mucous membranes, purpura.

3.Some patients have bone and joint pain, renal colic, fever, left upper quadrant discomfort, heavy pressure or pain.

4.Hepatosplenomegaly, with splenomegaly prominent.

5.Patients with advanced disease may have severe anemia and bleeding.

Myelofibrosis is a malignant blood disease, and it is important to find the disease as early as possible and without delay.

If you meet the conditions for enrollment, you can take the drug free of charge. First of all, you need to come to our hospital to check whether you can be enrolled.

Jiangsu Provincial People's Hospital-Department of Hematology-Chief Physician Qian Sixuan.