What are the characteristics of tuberous sclerosis complex? What are the characteristics of tuberous

The performance mainly includes the following aspects: First, the damage of ** is the most characteristic significance.

Sebaceous adenomas usually appear at the age of four to five years old, and are distributed in the triangular area of the mouth and nose in a butterfly shape, which are symmetrically scattered with pink lines the size of pinheads, and are light brown and translucent papules.

Second, there is damage to the nervous system: it can manifest as seizures, mental retardation, abnormal behavior, impulsivity, monoplegia or hemiplegia, and paraplegia.

Symptoms of extravertebral systems include cerebellar ataxia and increased intracranial pressure.

Thirdly, the damage to the eye can be manifested as: membranous lens tumor, glaucoma, microphthalmia, proptosis, lens opacity, cataract, vitreous hemorrhage, retinitis pigmentosa, retinal hemorrhage and primary optic nerve atrophy.

Fourth, there are skeletal changes that can include: bone calcification and cystic changes, spina bifida, polydactyly deformity, congenital dislocation of the hip joint, and so on.

Others include cardiac rhabdomyomas, lung cysts, and hyperfunction of the parathyroid glands.

Tuberous sclerosis complex is a rare autosomal dominant disorder. It can affect multiple organs such as the heart, brain, kidneys, lungs, etc., with a variety of manifestations, and it is easy to misdiagnose and miss the diagnosis. **The main performances are:

Phyllodes leukoplakia, facial angiofibroma, mackerel skin spots, periungual fibromas, forehead fibromas, gingival hyperplasia, soft fibromas, coffee spots, gray hair, etc.

1. Tuberous sclerosis.

The disease is a genetic disease, which can be divided into four types according to gene positioning: TSC1, TSC2, TSC3, and TSC2 mutations cause abnormal function of hamartoma protein and nodular protein, respectively, affecting their cell differentiation and regulatory functions, resulting in abnormal cell growth and differentiation in ectoderm, mesoderm and endoderm.

The mode of inheritance is autosomal dominant, and familial cases account for about one of the third tremors, that is, the mutated TSC1 or TSC2 gene inherited from one parent; Sporadic cases account for about two-thirds of cases, i.e., patients are born with a newly mutated TSC1 or TSC2 gene and no family member has the disease. TSC1 mutations are more common in familial patients, while TSC2 mutations are more common in sporadic patients.

2. White spots. 1) Dietary differences can cause vitiligo (vitiligo) Drinking alcohol and eating seafood can easily lead to the onset of many diseases, and vitiligo (vitiligo) is no exception. In addition, if vitiligo patients drink too much alcohol, it will cause the expansion of vitiligo, which will make the vitiligo condition nervous.

Excessive intake of vitamin C can also easily cause vitiligo (vitiligo), vitamin C to the field of tyrosine metabolism, inhibit the oxidation of dopa, can make the loss of pigment in the ** is vitiligo (vitiligo) Xuan pigment is restored to a colorless substance, changed into a water-soluble colloidal substance, so that the pigment is eliminated, those who love beauty must not bet on their own health.

2) Body inflammation causes vitiligo (vitiligo) Inflammation of the body is easy to trigger vitiligo (vitiligo), especially **inflammation. When the human body has inflammation, the body will have inflammatory reactions. A variety of substances are released in response to inflammation and can damage pigment cells.

Inflammation of chiral disease, due to the liquefaction and degeneration of basal endocytes, causes the loss of melanocytes in the potato segment, and further provokes the white patches of the distal septal region (vitiligo). Therefore, it is not beneficial to enhance physical training, improve body immunity, and prevent the onset of body inflammation, which is not beneficial to prevent the onset of vitiligo (vitiligo).

The manifestations of tuberous sclerosis complex are varied, mainly manifested as ** changes, seizures, mental retardation, etc., and the specific clinical manifestations are as follows:

1. Manifestations: Typical changes of tuberous sclerosis include depigmented plaques, facial fibroids, nail fibromas and shark-like changes at the waist, which can gradually appear with age, and 90% of children can have **depigmented plaques at birth, which are oval-shaped, willow-shaped white plaques;

2. Nervous system manifestations: 80%-90% of patients will have seizures, various seizure types can occur, common spasms in infancy and early childhood, 60% of children show mental retardation or mental and behavioral disorders ranging from mild to severe, and autism is common;

3. Pulmonary manifestations: mainly lymphangiomyoma in the lungs, which can destroy lung tissue, resulting in shortness of breath, cough and chest pain in patients, and the incidence rate in women is higher;

4. Renal manifestations: angiomyolipoma can occur, with an incidence of about 80%, which is common in women;

5. Cardiac rhabdomyomas: about 2 3 children will have cardiac rhabdomyomas, which occur in utero or shortly after birth, most of them are asymptomatic, and some children can resolve on their own in the early stage;

6. Retinopathy: obvious cases can cause vision loss.

In summary, the manifestations of tuberous sclerosis complex are diverse, with varying degrees of clinical manifestations.

Tuberous sclerosis complex is caused by mutations in genes, mainly in the TSC1 and TSC2 genes, and 80% of patients find mutations in this gene locus. Tuberous sclerosis complex is a neurological syndrome that can affect multiple systems throughout the body, and the most common symptom is ** changes. 90% of patients with tuberosclerosis have seizures, except for absence seizures, almost all seizure types can occur, and seizures in patients with tuberosclerosis are about 1 3 within one year of age, if not controlled as soon as possible, hail can affect children's intelligence and movement.

Seizures must be controlled as soon as possible after the diagnosis of tuberosclerosis is confirmed.

In this case, your baby has a relatively large white birthmark, which can be lasered**. Your baby's birthmark can be used with laser**, the area is relatively large, the repair time is longer, at least about 6-10 times, after the laser**, with the use of cell tissue repair solution for external rubbing, the effect is very good. The above is a reflection on the question "Is the white birthmark of a mixed-race baby tuberous sclerosis?"

Advice on this issue, I hope it will be helpful to you and I wish you good health!

The earliest clinical manifestation of tuberous sclerosis complex is vitiligo. As a mother, you will often notice a variety of red and black, brown, blue, purple, white and other colors on the baby's body, when found, people around will often tell the young baby parents: this is a birthmark, it's okay!

But in fact, sometimes these notes are not completely fine, such as some multiple coffee spots White spots are also a very common mark when the baby is born, however, if these notes appear such characteristics, we must be vigilant, it may indicate that the child is tuberous sclerosis, and the child should be assessed as soon as possible to see if there are other abnormalities, and consult the appropriate personnel to diagnose and intervene as soon as possible.

Willow-like leukoplakia located on the back of the lower back: these leukoplakia are usually oblong or oblongate in shape of one to several centimeters, like willow leaves, and the leukoplakia due to tuberous sclerosis complex is hypopigmented macula, not depigmented macula) but not as pigmentless porcelain white as in vitiligo or mottled disease; The long axis of the leukoplakia is usually consistent with the dermatodermal striae.

Tuberous sclerosis complex is one of the few difficult diseases that can be intervened with drugs or **. "Tongsan Soup for Eliminating Knots" is currently an effective drug for tuberous sclerosis, one person and one party targeted, dialectical treatment for each person, treatment for the disease, if used correctly as soon as possible, it can prevent or alleviate many serious complications. So how do you use it as early as possible?

Early diagnosis is key.

Tuberous sclerosis: This disease is relatively common in life, and it is a disease with a relatively high incidence. It will cause very serious harm to the patient's health, and if it is not carried out in time**, it may even cause white spots on the body, which will seriously affect the patient's appearance.

All patients should be treated as soon as possible after this happens to control the progression of the disease as soon as possible and avoid accidents.

For the white spots caused by tuberous sclerosis, we must not take it lightly, so as not to cause a delay in the disease, otherwise it will easily lead to a series of symptoms in the patient, and even induce seizures, so we must not take it lightly. For this symptom, we should take Chinese herbal decoction as soon as possible for conditioning**, and the third is personalized symptomatic treatment, which can accelerate the improvement of the disease, so that the patient can recover faster.

The first lesions of tuberous sclerosis complex appear as leaf-like leukoplakia, long leaf-shaped depigmented plaques that are distributed along the trunk and extremities. It often occurs in children born or in infancy, from one to dozens of scattered distribution, which is more obvious under the noon lamp, reflecting leaf-like, round, oval, etc., but mostly leaf-like.

Every patient is different!

Early** to avoid aggravation.