Rituximab adverse reactions, benefits and disadvantages of using rituximab

Non-Hodgkin lymphoma is caused by abnormal B cells. Unlike traditional forms of non-Hodgkin lymphoma** that destroy tumour cells, they also damage healthy tissues in the body, whereas rituximab only targets B cells.

Rituximab bonds to the surface of normal and malignant B cells, and through this bonding, it helps the body's immune system recognize and kill cancer cells.

Normal B cells replace the killed cancer cells, and the immune system reinfuses healthy cells.

What is a monoclonal antibody?

A monoclonal antibody is an artificial substance, similar to the body's own antibodies, that can recognize specific targets on the surface of cells.

Each monoclonal antibody recognizes only one target.

Monoclonal antibodies can be used in a single ** or in combination with chemotherapy**.

Monoclonal antibodies can make tumor cells more sensitive and improve the effectiveness of chemotherapy.

The bad thing is that the drug is expensive and not affordable for ordinary families.

In the tank! What is the policy of only increasing the amount of medical insurance, but not including high-cost self-financed life-saving drugs in the scope of medical insurance? Hollow gnocchi !!

Rituximab is an imported chemotherapy drug, which is generally used for the treatment of tumors, and in recent years, the clinical low-dose drug for the treatment of ITP has a good effect. Intelligently encloses B cells in the human body. The onset of action is generally 2-4 weeks, and there are also insensitive ones that take effect in 6-10 weeks, and the maintenance time is 10-12 months.

There are also good effects that can last for 2 years.

Some people say that Rituxima** costs 100,000, which is a dose of 5 sticks at a time, once a week, and 20 sticks for four weeks. A Meritux ** in Beijing is more than 4,100, and 20 is almost 100,000.

I use Rituximab ** once a week, 2 sticks at a time, that is, more than 8,000, and more than 33,000 after four weeks.

I don't know how other hospitals use rituximab, I used the medicine in Beijing 301 Hospital, and the director of the hematology department at that time said that according to the clinical effect, the effect of using 5 vials per week is the same as the effect of using 2 vials per week, and the situation of 1 vial is not very good, so at least 2 vials should be used.

I checked Rituximab's *** on the Internet, and I also asked the doctor, and the doctor said that this medicine is actually not too big***, that is, there will be breath-holding and allergic reactions during the infusion process, prepare in advance, and there is generally no situation with anti-allergy injections, and few people have too big a reaction. However, there are exceptions, the neck is swollen during the infusion process, and you can't breathe, so there is no big problem if you stop the infusion immediately.

The first time I lost, I was also a little breathless, the whole process was infused with oxygen, and then it was slowly better, in these four weeks, the third time because the needle was not pricked, the liquid penetrated into the subcutaneous, at that time the whole arm was numb, and the infusion place was swollen with a bag, but this is an imported chemotherapy drug after all, unlike ordinary chemotherapy drugs that cannot penetrate, and the entire blood vessel is completely necrotic after penetration.

After the first injection, the platelets rose from 10,000 to 30,000, but after the second injection, it dropped again, and the third shot slowly took effect, and after the fourth injection, my platelets rose to 60,000 and I was discharged from the hospital.

After I was discharged from the hospital, I added traditional Chinese medicine from Beijing Dongzhimen Hospital, and it has been maintained very well, and the platelets gradually rose to normal, generally maintaining between 100 and 300.

At the end of August 10, the platelets dropped to 9,000 again, I don't know if the effect of rituximab was or what it was, at this time my hormone was 2 tablets a week, half a tablet a day from Monday to Thursday, and I didn't take it for the next three days.

This time I was admitted to the hospital, the doctor suggested that I cut the spleen, but my family was worried that there was no effect after the cut, so I chose not to cut it, the role of the spleen in Western medicine is not great, but the role of the spleen in Chinese medicine is very large, I also think that there is no way to cut it.

At the end of August this year, when the platelets fell off, because I was already engaged, and the engagement was on October 20, I wanted to be hospitalized after getting married**, after a month, I had menstruation at the end of September, and I was urinating blood again, so I couldn't stand it anymore and had to be hospitalized again.

This time, the doctor considered that the effect was good last time, and continued to choose to use rituximab**.

You can't take the medicine casually, you have to follow the doctor's instructions, but this medicine ** I know that last time a colleague got it from a Walt Pharmacy near Jordan, Hong Kong, there were a lot of people, basically tourists.

What is the situation, you can't use it indiscriminately.

Rituximab is contraindicated in patients with non-Hodgkin lymphoma who are known to be allergic to any component of this drug and to murine proteins. Patients with rheumatoid arthritis are not suspected of having a large allergy to the active ingredient or any of the excipients in the prescription. Patients with severe activity** infection or severe impairment of the immune response (e.g., hypog-globulinemia, severely decreased CD4 or CD8 cell counts) should not be treated with rituximaban anti-anti-CD** (see Precautions).

Similarly, rituximab should not be used in patients with severe heart failure (NYHA classification IV). The combination of rituximab and methotrexate is contraindicated during pregnancy.

The main active ingredients of this product are recombinant rituximab excipients, including sodium citrate, polysorbate 80, sodium chloride and water for injection.

Therefore, nursing staff should introduce the main pharmacological effects, advantages, process and adverse reactions of rituximab to patients in detail, so as to reduce the psychological pressure of patients and enhance their confidence.

Fever is the main adverse reaction of rituximab and is a manifestation of cytokine release syndrome. Antipyretic analgesics (such as indomethacin) and antihistamines (such as diphenhydramine) should be given according to the doctor's instructions before taking the drug, and once fever occurs, the infusion of the drug should be stopped immediately, the body temperature should be measured, and the doctor should be reported at the same time. One patient in this group had a febrile reaction with a body temperature of 38, and the body temperature decreased after the application of dexamethasone, and the infusion was re-infused slowly at the specified rate at the beginning for 30 minutes, and no adverse reactions occurred.

Approximately 10 percent of patients with cytokine release syndrome developed with rituximab injection** had hypotension and bronchospasm. Hypotension and tracheal spasm should be temporarily discontinued, and analgesics, antihistamines, and occasionally oxygen, intravenous saline, or bronchodilators should be used, which are often transient and reversible. When symptoms are relieved, the infusion can be continued.

Each time you take the drug, you should strictly follow the doctor's instructions to adjust the infusion speed and monitor vital signs, and report to the doctor immediately if you find abnormal blood pressure, and deal with it in time.

What are the adverse effects? There are many kinds of them.

After using Rituximab, you will feel muscle aches and occasional heart palpitations. Under normal circumstances, it can be overcome, and after the muscle soreness is over, you must exercise, so that your physical strength will recover, and eat more high-protein foods