The mechanism of Meilan s rescue of sodium nitrite poisoning

The principle of nitrite poisoning is that it is associated with hemoglobin.

The effect is that normal ferric iron is oxidized to ferric iron, forming methemoglobin. Methemoglobin can inhibit the normal hemoglobin function to carry oxygen and release oxygen, thus causing tissue hypoxia, especially the central nervous system.

Hypoxia is more sensitive. After being absorbed by animals, nitrite ions can quickly oxidize the divalent iron of hemoglobin to ferric iron, and hemoglobin is oxidized to methemoglobin, thereby preventing the oxygen-carrying and oxygen-releasing functions of normal hemoglobin, causing tissue hypoxia and leading to organ dysfunction.

Melin (methylene blue.

Application: It is a specific antidote for nitrite poisoning, which can reduce methemoglobin and restore normal oxygen delivery function. The dosage is calculated as 1 2 mg per kg of body weight.

Detoxification principle: Meilan is a redox agent.

When applied in small doses, it has a reducing effect in the body, which can reduce methemoglobin to low hemoglobin to restore its ability to combine with oxygen, and a large dose of melanin enters the body with oxidative effect, which can oxidize low hemoglobin to methemoglobin. Vitamin C

Also known as ascorbic acid.

In vivo, it can exist both oxidized and reduced. Therefore, hydrogen donors and hydrogen acceptors can form and participate in many biological oxidation processes in the body, promoting the reduction of methemoglobin to normal hemoglobin.

The red blood cells of normal animals have substances that reduce methemoglobin, such as VC and each tathione. If the oxidizing capacity of nitrite entering the body exceeds the reducing capacity in the body, the animal has obvious symptoms of poisoning. After detoxification, the liver is bright red.

It can inhibit nitrite poisoning. Catalyzed by reduced coenzyme 1, it became a reduced Mayland. Reduced melanan reduces methemoglobin to hemoglobin.

It is also oxidized into an oxidized Meilan. And so on and so forth, and again and again. Therefore, the one-time dosage of Meilan should not be too large, and repeated application should not be restricted to prevent Meilan poisoning.

If the dosage of melanis is too large, NADPH cannot reduce all of it to reduced melan, and at this time, melan, as an oxidant, can directly oxidize normal hemoglobin to methemoglobin and aggravate the condition.

The principle of nitrite poisoning is that it interacts with hemoglobin, so that normal divalent iron is oxidized to trivalent iron, forming methemoglobin. Methemoglobin can inhibit the normal hemoglobin function of carrying oxygen and releasing oxygen, thus causing tissue hypoxia, especially the central nervous system, which is more sensitive. After being absorbed by animals, nitrite ions can quickly oxidize the divalent iron of hemoglobin to ferric iron, and hemoglobin is oxidized to methemoglobin, thereby preventing the oxygen-carrying and oxygen-releasing functions of normal hemoglobin, causing tissue hypoxia and leading to organ dysfunction.

Application of methylene blue: It is a specific antidote for nitrite poisoning, which can reduce methemoglobin and restore normal oxygen delivery function. The dosage is calculated as 1 2 mg per kg of body weight.

Detoxification principle: Meilan is a redox agent, when applied in small doses, it has a reducing effect in the body, which can reduce methemoglobin to low hemoglobin to restore its ability to combine with oxygen, and a large dose of Meilan enters the body with oxidation to oxidize low hemoglobin to methemoglobin. Vitamin C is also known as ascorbic acid.

In vivo, it can exist both oxidized and reduced. Therefore, hydrogen donors and hydrogen acceptors can form and participate in many biological oxidation processes in the body, promoting the reduction of methemoglobin to normal hemoglobin.

What is the anti-rust principle of sodium nitrite? It is a passivation effect that acts as a protective layer on the surface, and isolates the air to prevent oxidation.

There is also atropine sulfate and VC combined with intramuscular injection to replace methylene blue^