Causes of nodular vasculitis, the best treatment for nodular vasculitis

Nodular vasculitis is a small vasculitis with a predominantly lymphocytic infiltrate. The clinical characteristics are more common in middle-aged women, occasionally in men, small nodules on the lower legs or feet, the surface of the nodules is normal or reddish, generally along the superficial veins, slight pain or tenderness, and generally no systemic symptoms. The course of the disease can range from weeks to months.

There are differing views as to whether the disease is an independent disease. Recently, it has been suggested that nodular vasculitis is only an early or mild form of hard erythema. Regarding the relationship between nodular vasculitis and hard erythema, when tuberculosis involves fat, it can cause both non-liquefied and liquefied panniculitis.

If there is significant vasculitis in the tissue section, but the changes in nodular granulomas are mild, and there is no or very little caseating necrosis, it is called nodular vasculitis.

Vasculitis is the infiltration of inflammatory cells in and around the blood vessel wall, accompanied by vascular damage, including fibrinous deposition, collagen fibrillar degeneration, endothelial cell and muscle cell necrosis, also known as vasculitis. Primary vasculitis is caused by direct action on the blood vessel wall, and vasculitis is caused by certain clinical signs and symptoms on the basis of vascular inflammation; Secondary vasculitis is caused by inflammatory lesions in adjacent tissues that spread to the blood vessel wall.

Superficial thrombophlebitis of the extremities presents with localized redness, swelling, and pain in the affected limb, with painful cord-like stiff bars or bead-like nodules palpable. deep vein involvement, depressed swelling of the affected limb, worsening swelling and pain during walking, relieved after lying still, dark red color, extensive varicose veins and telangiectasias; In later stages, there are local dystrophic changes with stasis dermatitis, hyperpigmentation, or superficial ulcers.

Quit smoking, because smoking can change the viscosity of the blood, and the blood becomes viscous and easy to stagnate.

There is more than one way to have nodular vasculitis, so what are the best ways to do it?

Nodular vasculitis is caused by tuberculosis with anti-tuberculosis**, and some anti-tuberculosis drugs can be taken orally. In patients with a high number of nodules, a short course of corticosteroids may provide temporary relief of symptoms. However, corticosteroids are generally not preferred.

Fibrinolysis** has recently been reported to be valuable, but controlled studies are lacking and thymosin may also be used. Patients with nodular vasculitis may also choose to have it performed using physical methods**. The nodule can be irradiated with a HeNe laser or magnetotherapy.

In terms of drugs, immunosuppressants and hormonal drugs, such as prednisone, are mainly used. In addition, plasma exchange can also be performed, that is, it can also be carried out with traditional Chinese medicine**, nodular vasculitis is mild or severe. The lighter ones are generally able to return to normal through comprehensive **, and the wide material deficiency can be restored to normal.

Can ** connective tissue diseases: including differentiated connective tissue diseases, undifferentiated connective tissue diseases, mixed connective tissue diseases.

Differentiated connective tissue diseases can be differentiated into: lupus erythematosus, dermatomyositis, scleroderma, Sjögren's syndrome, panniculitis, Behcet's disease, erythema nodosum, nodular panniculitis and other rheumatic immune diseases, mixed connective tissue disease is some of the diseases with differentiation.

Connective tissue disease complications are severe. It can cause damage to multiple organs such as heart, liver, spleen, kidney, and lung, and can cause life-threatening such as dyspnea, heart failure, and kidney failure.

Once the diagnosis is confirmed, as soon as possible, the pure Chinese medicine in our hospital has been clinically practiced for many years, and the effect is very good.

Erythema nodosum is a rheumatic nodule that is a disease of connective tissue in rheumatic immune diseases.

Vasculitis is a lesion of the general ** blood vessels, that is, superficial vascular lesions are called vasculitis. Putting it in this category, many diseases are related to it, for example, pulmonary fibrosis is also a type of vasculitis. We often say that vasculitis is manifested more in the upper limbs of the legs, which is a kind of vasculitis that has a direct causal relationship with immune factors, hemorrhagic vasculitis, granulomatous vasculitis, etc., collectively referred to as vasculitis.

So it's a disease of the immune system, and an immune system disease is not a particularly treatable disease.

Thrombotic vasculitis: mainly affects arterioles and veins, is characterized by intraluminal thrombosis, and presents with different clinical manifestations. The main ones are thromboangiitis obliterans, thrombophlebitis, malignant atrophic papulosis, livedo reticularis, thrombotic thrombocytopenic purpura, etc.

Nodular vasculitis is synonymous with erythema cara. Nodular vasculitis is thought to be an early and mild hard erythema. Nodular vasculitis is called nodular vasculitis if there is significant vasculitis in the tissue section, changes in nodular granuloma are mild, and there is little or no caseating necrosis.

Granulomatous lobular panniculitis and vasculitis associated with tuberculosis should be referred to as hard erythema and usually present with more pronounced caseating necrosis and tuberculoid granulomas.

A group of vasculitic diseases caused by allergies of various causes, mainly involving small blood vessels, particularly the postcapillary veins. It is characterized by fibrin deposition, degeneration and necrosis in the tube wall and surrounding tissues, infiltration of a large number of neutrophils and nuclear fragmentation into nuclear dust. The onset is mostly acute, and there are often different forms of ** lesions.

The main ones are allergic ** vasculitis, allergic systemic vasculitis, Henoch-Schonlein purpura, hypocomplement (urticaria-like) vasculitis, etc.

Nowadays, the onset of nodular vasculitis gradually tends to be young, mostly located in the back of the lower leg. In the early stage, there are no significant symptoms, and with the severity of the disease, it will cause **small nodules, soreness and weakness of the lower limbs, etc., therefore, in order to alleviate its symptoms, patients need to treat the symptoms in time**.

Nodular vasculitis is generally referred to as polyarteritis nodosa, polyarteritis nodosa is a more common vasculitic disease in our rheumatology and immunology department, it is recommended to go to a regular hospital for treatment, as soon as possible**.

The course of nodular vasculitis is characterized by reversal. The disease is often caused by an adverse immune response in the body caused by a bacterial infection. Often, the effect is good at the time, but it is easy to reverse.

I advise, first of all, to be sufficient, and not to stop after the symptoms improve slightly. Second, rest after getting better is very important. During the onset of the disease, we emphasize absolute bed rest, and after getting better, we should not be tired, and we should not droop our calves for a long time.

Strenuous exercise such as hiking and running should also be avoided. Third, prevent colds.

Because a cold can reduce the body's immunity, it is easy to cause bacterial infections again, which leads to the continued development of nodular vasculitis.

There are many options for medication, and you can go to the hospital to get help from a doctor. This disease is cured.

Allergic vasculitis.

The disease only affects **, mostly occurs in young adults, generally has fatigue, joint muscle pain and other symptoms A few cases can have irregular fever, but it can also be absent from the above symptoms **The lesion can be pleomorphic with erythema, nodules, purpura, wheals, blood blisters, papules, necrosis and ulcers, etc Some begin to be subcutaneous nodules, such as soybeans to broad beans and jujubes, light red and tender, some begin to completely resemble purpura-like skin lesions, some skin lesions begin to resemble erysipelas, some resemble morpheous lesions, some resemble erythema multiforme, in the process of skin lesion development, can be accompanied by wheals, papules, etc., due to severe inflammatory reactions, blood blisters, necrosis and ulcers occur on purpura and purpuric maculopapular rashes, and some nodular lesions can also occur ulcers with pain. Edema is mainly concentrated in the ankle and dorsum of the foot, and is more obvious in the afternoon, accompanied by soreness and weakness of the two lower limbs. There are many kinds of skin lesions in this disease, but almost all of them have purpura or nodules Pustules can also appear when neutrophil multinucleated leukocytes extravasate into the surrounding tissues Skin lesions can occur in any part of the body, such as the back, upper limbs, buttocks, etc., symmetrically distributed Skin lesions have self-perceived pain, itching or burning sensation, some have no self-conscious symptoms, there is tenderness, pigmentation is left after the skin lesion heals, if there is an atrophic scar after the ulcer heals, when the lesion is acute, the lesion appears in batches, and it is widely distributed with calf edema, the disease is severe, and the damage is chronic, and the reverse action lasts for months or years If the lesion is mild, it can be healed in weeks Some lesions merge with each other and extend to form large lesions, often on the knees, elbows, and hands, which resemble long-lasting erythema emitterium.

It is more common in women aged 30 to 60, but it is also occasionally seen in men, the ratio of men to women is about 1:5, it is more common in the lower limbs, especially the back of the calf, the thigh, buttocks and upper arms can also be involved, the skin lesions are bright red, dark red and even normal skin color small nodules to large infiltrating plaques, round or oval, often first on the calves, generally similar to the size of broad beans, the nodules are hard, the surface is red, there is spontaneous pain or mild tenderness, 2 4 weeks disappear or leave fibrous nodules, most do not ulcerate, nodules often regurgitate after a certain period of timeIt spreads to the feet, thighs, and upper limbs, sometimes accompanied by joint pain and lower limb soreness and weakness, and the general condition is good, and other systems and organs are rarely involved.