How much dopamine is needed at least a day for Parkinson s disease

According to the situation you are talking about so far, the initial consideration is to consider the application of Qi Ju Dihuang pills, there is no curative effect, and you can seek medical treatment in time for relief. Patients with Parkinson's require routine use of tantan, or dopaserzine**.

In the early stages of Parkinson's disease, the disease is mainly controlled by drugs, but not all patients with Parkinson's disease can get a good remission after taking drugs. Some patients can delay the progression of the disease for up to ten years, but some patients can no longer control the disease after four or five years. At present, Parkinson's patients are taking basically the same drugs, but why is there such a big difference in effectiveness?

1. The patient's medication is not scientific.

Some patients do not know enough about Parkinson's disease and do not know that the disease requires long-term medication**, and take the medication** after the initial visit, and find that the condition is getting better and think**, so they do not take the medicine and do not return to the doctor. This will make the disease progress, and waiting until the condition is found to be serious again before taking medicine has missed the opportunity in the early stage.

2. The patient adjusts the medicine privately and increases the dosage.

Some patients find that the symptoms of the disease have improved significantly after taking Parkinson's disease drugs, thinking that the more drugs they take, the better the effect, so they do not listen to the doctor's instructions to increase the dose of drugs at will, and the result is counterproductive. There are some adverse effects of drug overdose, such as dizziness, dry mouth, constipation, orthostatic hypotension, uncontrollable movements, etc.

3. Worry about the drug is not good for use.

Parkinson's drug instructions are written in detail in terms of drug mechanism of action, indications, contraindications, adverse reactions, etc., many Parkinson's disease patients have a fear of the drugs they take, take the drug intermittently, and stop the drug immediately after the condition improves slightly, and continue to take the medicine only after the condition is aggravated, thinking that this adjustment can not only control the condition but also reduce it. Such a serious delay in Parkinson's disease makes the disease develop rapidly, and even if you want to take medicine in the later stage, it has little effect.

4. Patient's own factors.

Most patients with Parkinson's disease will be accompanied by depression and anxiety disorders, often accompanied by emotional changes such as irritability, panic, nervousness, anxiety, worry, depression, and worry. These emotional changes will aggravate the symptoms of Parkinson's disease, seriously affect the effect of Parkinson's disease, and the negative psychology will cause the disease to develop faster than the average patient, and even some patients will passively give up and not cooperate with the disease.

Drugs are also different from person to person, take drugs scientifically and reasonably, follow the doctor's instructions not to change the drug and dosage at will, and maintain a good attitude, so as to receive good results. This is the beginning of Parkinson's disease, patients still have a long way to go, and sticking to the right one is the key to Parkinson's disease.

Now that Parkinson's patients are not working well, I don't think they should increase the dose or change the drug, because he has become resistant to this drug, and there is no need to use this drug again.

Parkinson 's. The efficacy of the drug is getting worse and worse, should I increase the dose? I think it's also being maintained. So it's better to switch to traditional Chinese medicine. To recuperate, the effect may be better.

The disease does not mean that the higher the dose, the better, if the time is not good, we must change the method and strategy of our doctors to formulate the corresponding **.

Parkinson's patients are getting worse and worse, should the dose be increased? I think that the drug effect of Parkinson's patients is getting worse and worse, so it can only be to increase the dose or change to a new **, Parkinson's drug.

It is definitely not possible to continue to increase the dose, which is easy to have a negative effect, which is not conducive to the further improvement of the patient's condition.

Some patients find that the symptoms of Parkinson's disease have improved significantly after taking Parkinson's disease drugs, and they think that the more drugs they take, the better the effect, so they do not listen to the doctor's instructions and arbitrarily increase the drug The consequences are very serious.

Parkinson's patients are getting worse and worse, should the dose be increased? I don't think it should be, we still follow the doctor's instructions to carry out good control drugs, but I think we should accompany him more and do more physical ** and acupressure massage on him, so that his condition can be relieved.

Parkinson's patients are getting worse and worse at the drug, should the dose of the drug be increased? Patients with Parkinson's disease are getting worse and less effective, and the dosage should be increased according to the doctor's instructions.

The main reason for the deterioration of drug effect in Parkinson's patients Parkinson's disease, as a degenerative chronic disease of the nervous system, has a "drug honeymoon period" in the process of **, which is the time ,.. when Parkinson's disease patients are better controlled with drugs

This question depends on whether you use Western medicine and Western medicine that are empty of people and money or traditional Chinese medicine that requires money! Chinese medicine has to be reformulated!

The prominent pathological changes in Parkinson's disease are the degeneration and death of dopamine (DA)ergic neurons in the substantia nigra in the midbrain, a significant decrease in the content of DA in the striatum, and the appearance of eosinophilic inclusion bodies in the cytoplasm of residual neurons in the substantia nigra, i.e., Lewy bodies. At the onset of clinical symptoms, the death of dopaminergic neurons in the substantia nigra is at least 50%, and the DA content of the striatum is reduced by more than 80%. In addition to the dopaminergic system, the non-dopaminergic system in patients with Parkinson's disease is significantly impaired.

For example, cholinergic neurons in the basal nucleus of Meynert, norepinephrgic neurons in the locus coeruleus, serotonergic neurons in the suture nucleus in the brainstem, and neurons in the cerebral cortex, brainstem, spinal cord, and peripheral autonomic nervous system. A significant decrease in striatal dopamine content is strongly associated with the appearance of motor symptoms in Parkinson's disease. The significant reduction of dopamine concentrations in the midbrain-limbic system and the midbrain-cortical system is closely related to the occurrence of mental decline and affective disorders in patients with Parkinson's disease.

It is a decrease in dopamine secretion in the human brain, or the secretion can not maintain the needs of the human body, the lack of dopamine is one of the first, and there are also genetic reasons, but there is still no accurate answer to the specific reason, which is a recognized medical problem.

The equivalent amount of levodopa can be used as a reference for the measurement of medication taken by Parkinson's patients, and 100 mg of L-Contra is equal to 100 mg of amantadine.

Take Medopa, a commonly used drug for Parkinson's disease, as an example

1.Initial**. The first recommended dosage is 1 2 tablets (125 mg) of Medopar three times daily.

After that, the daily dosage of 1 2 tablets per week is increased until the ** dose suitable for the patient is reached. If the patient visits the doctor regularly, the dosage can be increased more quickly, for example, the daily dose can be increased twice a week, each time by increasing the medopar 1 to 2 tablets, so that the effective dose can be reached more quickly, and the effective dose is usually between 2-4 tablets per day, divided into 3-4 times a day. It is rare to take more than 5 tablets of Medopar per day.

2.Sustain**. The daily dosage of medopar should be divided into at least 3 doses, and the average maintenance dose is 3 times a day, one tablet of medopar each time.

However, because improvement in symptoms may fluctuate, daily dose allocation (in terms of the dose taken by each patient and the timing of the dose) depends on the individual patient.

Drugs are the most effective in Parkinson's disease. There is no need to use drugs in the early stage, and if the disease affects the patient's daily life and work, drugs can be used**, adhere to the principle of "fine water and long flow, not seeking full effect", and emphasize the individualization of medication. Doctors should give different drugs according to the patient's gender, age, symptoms, severity of illness and response to drugs, starting with small doses and gradually achieving the best effect until the mildest, and then maintaining the dose.

For example, medopa** is often started with a low dose of 125 mg orally 3 times a day, with an increase of 250 mg a day every 7 days, and the number of simultaneous doses increased to 4 to 5 times a day. Preprandial medication is more effective than postprandial medication, and it is generally recommended to take the medication 1 hour before or 2 hours after a meal. Patients should strictly follow the doctor's instructions to take the medication, clarify the time and dosage of the medication, and develop good compliance.

When the prepared drugs are insufficient, the source of drugs should be replenished in time.

The drug has a certain ***. Antan*** has dry mouth, decreased saliva and sweat secretion, dilated pupils, blurred vision, constipation and urinary retention. Amantadine *** has restlessness, insomnia, dizziness, headache, nausea, reticular greendoes of the lower limbs, ankle edema, etc.

Because of the peripheral decarboxylation effect, the adverse reactions of medopa are multifaceted, such as nausea, vomiting, abdominal discomfort and so on in the digestive system; The cardiovascular system has arrhythmias, orthostatic hypotension, etc.; The urinary system has urinary retention, urinary incontinence, aggravated constipation, etc.; The nervous system may present with restlessness, insomnia, hallucinations, delusions, etc. [1]. After taking the drug, the patient should be instructed to rest in bed for 20 to 30 minutes or take morpholine at the same time to reduce symptoms, and pay attention to heart rate, heart rhythm, etc. Long-term use of medobar can cause complications such as fluctuating symptoms, movement disorders, and psychiatric disorders, which generally appear after 4 to 5 years of use.

When using levodopa alone, it is forbidden to use it with vitamin B6 at the same time, because the latter is a coenzyme of dopa decarboxylase, which can accelerate the decarboxylation of dopa outside the brain, reduce the concentration of levodopa in the blood, reduce the amount of levodopa into the brain tissue and reduce the efficacy, and increase its periphery***. Monoamine oxidase inhibitors can cause a sudden increase in blood pressure when combined with levodopa, diazepam, phenothiazine, haloperidol, clonidine, papaverine, phenytoin, and reserpine can antagonize the effect of levodopa, and should be contraindicated. After the occurrence of adverse reactions, patients do not need to be nervous, do not suddenly reduce or stop the drug, and should consult a doctor in time to adjust**.

Most patients are able to continue taking the medication after adjusting the medication.