What are the signs of tuberous sclerosis? What are the symptoms of tuberous sclerosis?

Tuberous sclerosis complex is a genetic disorder of the chromosomes.

Hello, tuberous sclerosis complex is a chromosomal genetic disease, so most of them will occur when the baby is very young. There will be a red spot on the face, and there will also be a ** on the waist and abdomen. If it affects the nervous system, symptoms of epilepsy may occur, and it must be controlled in time.

It can also affect mental development, impulsivity and other conditions. I hope my reply is helpful to you.

1.**Damage.

It is characterized by a triangular area of the mouth and nose, symmetrically butterfly-shaped, pale red or reddish-brown, and a hard, waxy papule the size of a pinpoint to a broad bean, which fades slightly. More than 3 of these depigmented plaques and subungual fibroids are the most characteristic lesions.

2.Neurological damage.

1) Epilepsy is the main neurological symptom of the disease, with an incidence of 70% to 90%, starting from infancy and early childhood, and the seizures are diverse, ranging from infantile spasms to partial focal or complex seizures and generalized grand mal seizures.

2) Mental retardation is more progressive, accompanied by emotional instability, naïve behavior, impulsivity and thinking disorders and other mental symptoms, almost all people with mental retardation have seizures, early-onset epilepsy is prone to mental decline, seizures with abnormal peak rhythm EEG often have severe intellectual disability, and some patients can manifest as autism.

3) A small number of positive neurological signs may be present. For example, extrapyramidal signs or monoplegia, hemiplegia, paraplegia, tendon hyperreflexia, etc., such as subependymal nodules blocking cerebrospinal fluid circulation pathways or local giant nodules, and concurrent tumors can cause intracranial hypertension.

The symptoms of tuberous sclerosis complex are:1Renal lesions, etc.

2.The eye area is red and swollen, and there is a yellowish-white ring lesion. 3.

Heart and lung lesions may occur. 4.Nervous system damage can occur.

It can be done by plain skull x-ray, electroencephalogram, and cerebral effusion. Be sure to detect it early, and don't put it off again and again.

Symptoms of epilepsy may occur, and it is important to control it promptly. It can also affect mental development, impulsivity and other conditions.

The disease is often manifested as multi-system involvement, and its occurrence and development have certain stages, and its core organs involved include the nervous system and **, kidneys, and lungs.

Cardiac rhabdomyomas often occur in the fetal neonatal period, most of which resolve spontaneously, and significant mental decline and seizures often occur within 2 to 3 years of age.

Different** lesions can occur at different ages, with facial lesions usually appearing between the ages of 4 and 10 years and gradually worsening thereafter.

1. Damage.

**The lesion is characterized by the presence of a sebaceous adenoma in the triangular area of the mouth and nose. And this adenoma will be distributed in a butterfly shape, and it is maroon or red on the outside, and the size is inconsistent, some are as small as the tip of a needle, and some are about the same size as a broad bean. And it is relatively hard to the touch, and as we age, the area of damage will continue to change, which may occur on the forehead or upper lip.

2. Nervous system damage.

70-90% of patients with tuberous sclerosis complex will have seizures. Patients with frequent seizures may have personality changes with stable stubbornness and dementia. Some patients may have progressive exacerbations and mental retardation, usually accompanied by mental abnormalities such as naïve behavior, emotional instability, impulsivity and confusion, and the symptoms of mental retardation are common to almost all patients with seizures.

3. Ocular symptoms.

Half of patients with tuberous sclerosis complex will have retinal glioma. Fundus examination may reveal multiple egg-like calcified nodules, and there may also be yellowish-white ring-shaped lesions around the retina. In addition to this, patients may also have symptoms such as glaucoma, cataracts, retinitis pigmentosa, retinal hemorrhage, and primary optic nerve atrophy.

4. Heart disease.

Cardiac disease is also a symptom that patients with tuberous sclerosis complex are more likely to experience. The disease can lead to heart failure as it progresses, and this condition is the biggest cause of death in people with tuberous sclerosis.

Tuberous sclerosis.

First of all, the patient** will have obvious skin lesions, and the skin lesions generally occur in the mouth and nose triangle. Tuberous sclerosis complex also causes a nervous system reaction, so the body will have convulsions when the patient is sick, similar to epilepsy. Later, it will be found that the patient's intelligence will be reduced, his emotions will be unstable, and he will even be impulsive.

The performance mainly includes the following aspects: First, the damage of ** is the most characteristic significance.

Sebaceous adenomas usually appear at the age of four to five years old, and are distributed in the triangular area of the mouth and nose in a butterfly shape, which are symmetrically scattered with pink lines the size of pinheads, and are light brown and translucent papules. Grinding the world.

Second, there is damage to the nervous system: it can manifest as seizures, mental retardation, abnormal behavior, impulsivity, monoplegia or hemiplegia, and paraplegia.

Symptoms of extravertebral systems include cerebellar ataxia and increased intracranial pressure.

The third blind limb is the damage of the eye which can be manifested as: membranous lens tumor, glaucoma, microphthalmia, proptosis, lens opacity, cataract, vitreous hemorrhage, retinitis pigmentosa, retinal hemorrhage and primary optic nerve atrophy and so on.

Fourth, there are bone changes that can include: bone calcification and cystic changes, spina bifida, polydactyly, congenital dislocation of the hip joint, and so on.

Others include cardiac rhabdomyomas, lung cysts, and hyperfunction of the parathyroid glands.

The manifestations of tuberous sclerosis complex are varied, mainly manifested as ** changes, seizures, mental retardation, etc., and the specific clinical manifestations are as follows:

1. Manifestations: Typical changes of tuberous sclerosis include depigmented plaques, facial fibroids, nail fibromas and shark-like changes at the waist, which can gradually appear with age, and 90% of children can have **depigmented plaques at birth, which are oval-shaped, willow-shaped white plaques;

2. Nervous system manifestations: 80%-90% of patients will have seizures, various seizure types can occur, infants and early childhood often see spasms, 60% of children with fluid knowledge show mental retardation or mental and behavioral disorders ranging from mild to severe, and autism is common;

3. Pulmonary manifestations: mainly lymphangiomyoma in the lungs, which can destroy lung tissue, resulting in shortness of breath, cough and chest pain in patients, and the incidence rate in women is higher;

4. Renal manifestations: angiomyolipoma can occur, with an incidence of about 80%, which is common in women;

5. Cardiac rhabdomyomas: about 2 3 children will have cardiac rhabdomyomas, which occur in utero or shortly after birth, most of them are asymptomatic, and some children can resolve on their own in the early stage; Grinding gear.

6. Retinopathy: obvious cases can cause vision loss.

In summary, the manifestations of tuberous sclerosis complex are diverse, with varying degrees of clinical manifestations.

**The new method of tuberous sclerosis is to use electrode technology to locate the nodules, and then perform surgical resection according to the localization results**, the effect is very significant. In addition, the effect of drugs and other methods on tuberous sclerosis is relatively poor, because the difficulty of tuberous sclerosis is very large, and few drugs can, so drugs are not considered.