Do you know how gout is caused?

Gout is a disease caused by a disorder of purine metabolism, the most important biochemical basis of which is hyperuricemia. Purines are the constituent components of DNA in cells, and the end product of metabolism is uric acid, of which 80% is endogenous and 20% is exogenous. About 60% of this uric acid is metabolized daily, of which 1 3 is catabolized through the intestine and 2 3 is excreted by the kidneys, thus maintaining a stable uric acid level in the body.

Problems with any of these links can lead to hyperuricemia. The deposition of uric acid in the blood into the joints can cause recurrent arthritis and even joint deformities. If you pay attention to your lifestyle and add Fengcao tea to effectively promote the excretion of uric acid, then gout can not attack.

Gout can be divided into two categories according to different **:

1. Primary gout: hereditary, mainly due to the defect of purine metabolism enzymes, which may be a polygenic hereditary disease with a certain familial hereditary nature;

2. Secondary gout: refers to a clinical manifestation secondary to other diseases, and may also be caused by a certain drug. Secondary gout is divided into three categories, caused by excessive uric acid production, such as myeloproliferative diseases, such as leukemia, lymphoma, multiple myeloma, polycythemia, hemolytic anemia and cancer, etc., can lead to accelerated cell proliferation, increase nucleic acid conversion, and increase uric acid production; Uric acid excretion disorders, such as glomerular filtration dysfunction due to kidney disease, can reduce uric acid excretion, resulting in an increase in serum uric acid concentration; Drug-induced factors, such as thiazide diuretics and furosemide, can competitively inhibit the excretion of uric acid by the renal tubules, causing hyperuricemia.

Therefore, gout is a disease caused by many causes, and purine metabolism disorders are its common characteristics.

Gout is a heterogeneous group of diseases caused by chronic purine metabolism disorders, and primary gout is a hereditary disease, which is closely related to obesity, essential hypertension, dyslipidemia, diabetes mellitus, and insulin resistance. Secondary disease can be caused by a variety of factors such as kidney disease, blood disease, drugs, and high-purine foods.

Hello, gout is mainly caused by monosodium urate deposition, purine metabolism disorders, etc. It is also related to a good purine content diet and drinking, it is recommended to drink more water in the future, quit drinking, and a low-purine diet, hoping to help you.

Gout is the weak detoxification function of the liver, and uric acid is the product of incomplete detoxification of the liver. Therefore, it is necessary to improve liver function and reduce the burden on the liver.

The causes of gout are mainly secondary and primary, among which secondary gout refers to gout caused by hyperuricemia caused by underlying diseases, and gout is primary gout that excludes the factors of underlying diseases, and a small number of gout patients will also develop gout because they have genetic diseases with metabolic abnormalities.

Gout is mostly caused by elevated uric acid, joint swelling and pain caused by intra-articular deposition, which is related to purine foods in life and genetic factors. Excessive uric acid deposition in the joint cavity of gout causes joint pain, which is related to genetics and high-purine foods, pay attention to rest during an acute attack of gout, do not do strenuous activities, lift the affected limbs, take colchicine, ibuprofen**, usually do not include high-purine foods.

1. Genetic factors.

One of the causes of gout is genetics. Gout is an inherited metabolic disease with an obvious genetic predisposition, and if there is a family history of gout, the chance of suffering from gout will be much higher than that of ordinary people. Such genetically predisposed people lack an enzyme in their body to excrete uric acid, so that uric acid accumulates in the body, and the increase in uric acid in the blood will form crystals, which will accumulate in the joints and induce gout.

2. Obesity. The occurrence of gout is also closely related to body obesity, obesity can easily cause gout, because the larger the body surface area of the person, the higher the level of blood uric acid, so the blood uric acid level of obese patients is much higher than that of ordinary people, and gout will be formed over time.

4. Bad living habits.

Poor lifestyle habits are also one of the main culprits of gout. In real life, many people have various bad habits, such as staying up late for a long time and excessive fatigue, these bad habits will affect the abnormal metabolism of the body, and will also make the body more acidic, causing uric acid abnormality, and eventually inducing gout.

Western medicine calls it (gout) Chinese medicine calls rheumatism and rheumatoid belong to the category of "paralysis": wind, cold, and dampness are mixed with three kinds of evil qi to invade the human body to cause paralysis, and its clinical manifestations are: chronic, progressive, symmetrical joint pain, morning stiffness, early migration, diamond-shaped swelling of joint soft tissues, and gradually joint stiffness, deformity, rigidity, dysfunction, blood tests can show a decrease in red blood cell blood protein, rheumatoid factor is positive, and blood sedimentation rate is accelerated, It is generally believed (in the opinion of Western medicine) that the autoimmune response caused by the infectious agent leads to synovitis-based joint lesions; Traditional Chinese medicine believes that this disease is caused by the lack of qi and blood in the liver and kidneys, the invasion of wind, cold, dampness and heat, which leads to the obstruction of qi and blood, and the loss of nourishment of muscles, veins and joints.

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Gout is divided into primary gout, as well as secondary gout, if it is primary gout, it may be caused by genetic factors, if it is secondary ventilation, it may be caused by certain diseases, such as common blood diseases, leukemia, hemolytic anemia, etc., as well as lymphoma multiple bone marrow, etc., may cause the appearance of gout, gout patients should pay attention to keep warm, do not catch a cold.

How is gout caused In 1950, the crystals of uric acid were discovered, and we detected them under a polarized light microscope, and we looked at the extracted synovial fluid and this tophi under the polarized light, and we could see the crystals of uric acid in the form of needles, which confirmed that there was gout and the production of uric acid, and we gradually found that this gout was caused by abnormal purine metabolism. Whether we are genetically or polygenic mutations, the vast majority of gout is the cause of primary gout, the first is due to our genetic mutations, resulting in abnormal uric acid excretion, that is to say, our renal tubules will absorb uric acid, resulting in uric acid can not be discharged normally, uric acid excretion is reduced, so that the blood uric acid in our body increases, so it causes hyperuricemia, which is the first one, and most people are caused by this reason. Only 10% of patients are due to the uric acid produced after our gene mutation, and eventually this purine metabolizes and synthesizes uric acid, because of the purine metabolism, due to the mutation of the gene, our various enzymes are lacking and the enzyme activity increases, so that we produce too much uric acid.

Gout is a disease caused by excessive accumulation of uric acid in the blood in the body and deposited at the end of the limb, causing redness, swelling and pain in the affected area. Endogenous may be caused by disorders of purine metabolism and decreased uric acid excretion, and exogenous is usually related to diet, such as regular alcohol consumption, eating various broths, seafood products, animal offal, and meat that is too high in purines. Before the attack of gout, there is usually a history of high purine diet, many patients are attacked at night, and the most painful state is reached in about 12 hours after the attack, many patients are awakened by the pain at night, the pain is tearing, and the knife is more unbearable, often appearing in the first metatarsophalangeal joint, ankle joint, knee joint and other parts of the foot.

At the same time, there may be redness, swelling, pain, increased skin temperature, and limited activity of the joints, and the diagnosis can be confirmed by further examination of blood uric acid.

The main cause of gout is overeating, especially eating a large amount of purine-rich foods, that is, the acute attack of gouty arthritis caused by a high-purine diet.

Gout is caused by an increase in uric acid in the body and combines with stones in the blood to form tophi in the joints, which is very painful.

The ** and pathogenesis of gout are not known, but hyperuricemia is the most important biochemical basis of gout, under normal circumstances, human tissues contain purine substances, in addition, many foods also contain purines, and uric acid is produced after the purine in the body and the food eaten are broken down.

The main cause of gout is urate deposition in the joints and kidneys. This is mainly due to hyperuricemia caused by abnormal purine metabolism, hyperuricemia leads to urate crystallization, and the formation of hyperuricemia is mainly due to the decreased ability of the kidneys to excrete uric acid, such as decreased filtration function of spermatogenic cells, or enhanced renal tubular reabsorption function. It can also improve the secretion capacity of the renal tubules.

The increase in uric acid produced in the human body is mainly related to the lack of enzymes in the human body. In addition, the intake of high-purine foods from the outside world is also a reason.

Gout is a series of syndromes caused by disorders of purine metabolism in the body. Manifestations include gouty arthritis, tophi or gouty nephropathy. Common in middle-aged men, in recent years, the age of onset is earlier, closely related to diet, intake of high-purine foods, such as beer, seafood, soy products, etc. can induce gout attacks, some drugs can also cause an increase in purine content in the body, such as diuretics, aspirin, cyclosporine, etc.

Gout is one of the more common joint diseases in our lives. Moreover, the incidence of men is relatively high, which is directly related to the cause of gout. Gout is actually caused by the accumulation of uric acid in the joints and kidneys due to the increase in uric acid levels, which will form gout crystals and even tophi in the long run, causing joint pain and kidney damage.

The biggest cause of gout is dietary factors: too frequent consumption of seafood, spicy hot, beer, and hot pot will cause metabolic abnormalities and increase uric acid levels. In addition to dietary habits, there are also obesity or hereditary causes.

According to the cause of its occurrence, it can be divided into two categories: primary and secondary.

1.Primary.

1) Enzyme and metabolic defects: seen in the increase of PRPP synthase activity or partial or total deficiency of HGPRT, both of which make uric acid excessive, which is sex-linked inheritance, less than 1;

2) Unexplained cause: It mainly refers to the decrease in unexplained renal excretion and the excessive production of unexplained uric acid, which is polygenic inheritance.

2.Secondary.

1) Glucose-6-phosphate dehydrogenase (G6PD) deficiency increases uric acid production, such as glycogen storage syndrome;

2) Increased nucleic acid conversion, commonly seen after surgery, radiotherapy and chemotherapy, critically ill patients, chronic hemolysis, polycythemia, malignant tumors, bone marrow or lymphoproliferosis, etc.;

3) Increased purine intake: drinking alcohol and eating high-purine foods;

4) Decreased renal clearance: such as drugs, poisoning or endogenous metabolites such as ketone bodies, lactic acid and other factors inhibit uric acid excretion and/or increase absorption. It is more common in chronic nephritis, hypertension, dehydration, diabetic ketosis or acidosis, hypothyroidism or hyperthyroidism, chronic lead and beryllium poisoning, loop diuretics, and insulin resistance.

Gout is a type of acute and chronic inflammation and tissue damage caused by urate deposition in the bones, joints, kidneys, and subcutaneous areas. Hyperuricemia is the basis for the occurrence of gout, and can be divided into two main categories according to the different types of gout:

1. Primary gout: that is, gout caused by unexplained hyperuricemia, which is caused by environmental factors and genetic factors, and has a certain familial hereditary nature. Except for a very few caused by congenital purine metabolizing enzyme defects, the rest are mostly related to high-purine diet, and often coexist with obesity, hypertension, diabetes, coronary heart disease, etc.

2. Secondary gout: gout attacks caused by the decrease in uric acid excretion caused by kidney diseases, the inhibition of uric acid excretion by certain drugs, the increase in uric acid production caused by hematologic diseases, radiotherapy, etc.

At present, with the improvement of material living standards, a high-purine diet has become one of the main causes of gout. Alcohol, seafood, animal offal, beef and mutton, sweet drinks, etc. are the main types of high-purine diet, and long-term high-purine diet can cause an increase in blood uric acid, resulting in hyperuricemia. If the blood uric acid level rises for a long time, the urate concentration increases, forming crystals and depositing them in the joints and kidneys, leading to gout attacks.

However, it should be noted that simply an increase in blood uric acid does not mean gout, and the occurrence of gout must involve the formation and deposition of urate crystals.

To sum up, there are many reasons that can cause an increase in blood uric acid in the body and lead to gout, and those with blood uric acid index higher than normal should be treated in time, and the first and most intervention should be carried out to avoid gout attacks.

In most cases, gout is related to the patient's long-term consumption of high-purine foods, personal constitution, and genetic factors. Some patients like to eat soy products, seafood, and like to drink alcohol, which can lead to metabolic disorders and gout.