Why is hemophilia also called royal disease ?

It is because there was a queen who passed on the gene of hemophilia to her young son, which involved a lot of royal families, so it is also called royal disease in some countries.

Because those are the people who develop hemophilia. So there is this nickname.

Hemophilia Day is a genetic disorder that has ravaged European royal families and is characterized by bleeding after injury. Whether it's a tooth extraction, a minor surgery like a tonsillectomy, or just a fall or accidental injury, it will continue to bleed, which is very difficult to stopYou know that such a serious disease "noble" is called "royal disease". Why? Hemophilia can be divided into two types:

Hemophilia A and Hemophilia B.

Their symptoms are very similar and can only be distinguished by a special blood clotting test. The coagulation process involves 13 clotting factors. Hemophilia A lacks clotting factors, and hemophilia B lacks clotting factors.

They do not have a specific genetic determination. Once a genetic mutation occurs, it does not direct the synthesis of coagulation factors or factor IX, and functions normally. Both genes are located on the X chromosome, and the causative gene is recessive.

Hemophilia is a recessive genetic disorder.

Alexei, the son of Tsar Nicholas II, thanked Queen Victoria and her descendants. Alexei was the son of Tsar Nicholas II of Russia, and his hemophilia gene dates back to the time of Queen Victoria of England。From this, it can be inferred that the Queen's mother had a genetic mutation during the formation of her eggs, making her a carrier of the hemophilia gene.

The queen had four sons, five daughters and 42 grandchildren. Due to the prevalence of royal marriages in Europe at the time, these children and grandchildren were spread across many royal families in Europe, and Queen Victoria had a nickname called "the grandmother of European royalty".

The queen passed on the genes that cause hemophilia to her youngest son, making him a sick man. The queen also passed on the disease-causing gene to her two daughters. The two daughters passed it on to the Queen's four granddaughters.

Among the sons born to these carriers were hemophiliacs, involving many European royal families such as Germany, Spain, Russia, etc。Hence, hemophilia has a nickname "royal disease". Alexei's hemophilia genes came from his mother, Queen Alexandra, the granddaughter of Queen Victoria.

However, it has not been determined whether Queen Victoria carries the gene for hemophilia A or hemophilia B. In 2009, DNA analysis of Alexei's remains confirmed that "royal disease" is a relatively rare form of hemophilia B.

Because the price of this disease is very expensive, it is called that.

This is mainly because the money needed for illness is a lot, so it is called royal disease.

Hemophilia spread among the royal families of various European countries in the 19th century, so it was called "royal disease". The source of hemophilia was Queen Victoria, and then the influence gradually expanded to the royal families of various countries because of the marriage of various countries.

Hemophilia, also known as functional blood clotting disorder, is a genetic condition in which the patient does not produce thromboplastin well, resulting in bleeding that does not stop when injured, and spontaneous bleeding occurs even when the patient has no visible injuries. As a legacy disease, hemophilia is a problem that patients carry from their genes, so there is no possibility of hemophilia. With such a developed medical system in today's society, hemophilia can only be prevented, and Europe in the nineteenth century was even more helpless, and even many members of the royal family died of hemophilia.

Hemophilia, as a "royal disease", began its own "transnational journey" from Britain through political marriages in Europe. And the first communicator was the famous Queen Victoria at that time, Queen Victoria had a total of 4 sons and 5 daughters, so Britain began to carry out political marriages through Queen Victoria's children to stabilize the relationship between countries. I believe that the monarchs of various countries could not have imagined that this was the beginning of the disaster of the royal family, and hemophilia began to spread among the three major powers of Britain, France, and Russia, and gradually became a "royal disease".

So why did Queen Victoria and her husband, Prince Albert, become the spreaders of hemophilia? This is because Queen Victoria and Prince Albert are consanguineous marriages, and Queen Victoria carries the gene for hemophilia, and the genes for hemophilia in offspring are more obvious due to consanguineous marriages. Queen Victoria may not have imagined that the legendary "royal disease" ** would be on herself.

Hemophilia is a group of hereditary bleeding disorders that cause severe coagulation disorders due to the lack of certain clotting factors in the blood.

In the nineteenth century, hemophilia appeared in the British royal family, and in the process of marriage between the British royal family and European countries, hemophilia gradually spread to the royal families of European countries, so it is called royal disease.

Because this disease came from the Queen Victoria family of England in the nineteenth century, it was originally called the "hemorrhagic family", and later because the royal carrier passed this gene to other countries in the process of marriage, so the disease existed in the aristocratic royal family, so it is also called "royal disease".

Hemophilia, also known as hemorrhagic disease and royal disease, as a bleeding disorder with hereditary coagulation dysfunction, was frequently occurring in European royalty in the 19th century.

Since ancient times, European royal families have had a tradition of marrying each other. Marriage not only maintained the "noble blood" of the royal family, but also guaranteed the harmonious relations between European countries at that time. But since the 40s of the 19th century, a terrible bleeding disease has quietly spread with the marriage of princesses and princes, and has affected several European countries.

Therefore, hemophilia is also known as "royal disease", a serious hereditary disease.

Because the origin of hemophilia is in the royal family of Europe, this gene is transmitted to the royal family of other countries during the marriage process, so it is called royal disease.

The symptoms of hemophilia royal disease are generally bleeding as a symptom, which is caused by a lack of coagulation factors, it is best to go to the hospital for examination in time, you can draw blood to check the four items of coagulation, etc., at the same time, it is recommended to check the coagulation factors, etc., if there is a lack of coagulation factors, it is best to transfuse plasma in time, and it is recommended to pay attention to rest, avoid trauma, etc., and it is recommended to strengthen the diet and nutrition. It is recommended that patients go to a regular hospital for examination and acceptance**.

First of all, hemophilia was first discovered because it was widely spread in European royal families, so it was called royal disease, in fact, many people also called people with this type of disease glass people.

Because the disease was first the disease of the British royal family, and then they passed through the system of harmony, and the royal families of other countries were also infected. That's why it's called "royal disease." ”

Because the origin of this disease was in the European royal family, it later occurred frequently in the European royal family, and finally it was studied and found to be a disease caused by heredity.

Because hemophilia was first voiced in European royal families, and later frequently found in European royal families, it is called royal disease.

Hemophilia is an X-chromosome recessive genetic disease, which is transmitted from male to female, and the probability of consanguineous married couples carrying the same disease-causing gene is greater, and the risk of the next generation is greater.

Because this disease was frequent in the 19th century in European royalty with "noble blood and long live marriage", it was only after that that it was called "royal disease".

Today is World Hemophilia Day. This is a kind of bereavement or disease that once ravaged the European royal family, the patient is manifested as bleeding after injury, whether it is in tooth extraction, tonsil extraction and other minor surgeries or just accidental falls, accidental injuries will continue to bleed, difficult to stop, if it is a major operation or trauma, it will not stop bleeding, the consequences are unimaginable. Then did you know that such an unlucky disease, but it has a "noble" title, called "royal disease".

Why is that?

Hemophilia can be divided into two types: hemophilia A and hemophilia B. Their symptoms are very similar and can only be distinguished by a specialized coagulation test.

The coagulation process involves 13 clotting factors. Hemophilia A is a lack of clotting factors in the blood, and hemophilia B is a lack of clotting factors in the blood. Each of them is free of specific genetic determinations.

Once a genetic mutation occurs, it does not direct the synthesis of coagulation factors or coagulation factors that function normally. Both genes are located on the X chromosome, and the causative genes are both recessive genes, so hemophilia is a concomitant cryptohlotic chain genetic disease.

Because there was a queen of the Wang family who probably had this gene, his children were all inherited by this gene.

Because people with hemophilia generally don't like to exercise, that's why they get this disease.

Because the royal family often marries close relatives, this disease is the case.

Because the disease is a genetic disease, as long as there is one person in the royal family who has this disease, then there is a high probability that her offspring will be inherited.

Because hemophilia is because it does not like to exercise and is hereditary, it is called royal disease!

Because the carriers of hemophilia are women, and women are the subjects of reproduction of new life. Once a woman marries into the royal family with hemophilia, 80% of newborn babies in the royal family will carry the disease.

Because people in the royal family don't like to exercise, their blood is more prone to necrosis to have this hemophilia.

Because this disease is very rare, once it is inherited.

Because this disease is very rare, most people do not suffer from this disease.

Hemophilia is a"Inherited with sex"Disease, that is, this disease is related to the sex of the person. The gene for the disease is located on the X chromosome in the cell. Males have sex chromosomes of type XY, which causes the disease.

In females, the sex chromosome is XX, and the diseased X chromosome is compensated by another healthy X chromosome, so it does not develop the disease. But even though she doesn't get sick personally, the diseased chromosome continues to be passed on to their children. In the next generation, 1 2 of the males will develop the disease, and 1 2 of their daughters will become carriers of the hemophilia gene, so they will continue to inherit downward, which is the inheritance law of concomitant genetic diseases.

The main cause of genetic diseases is the marriage of close relatives. of royal blood"Purity", but it brought a family tragedy.

The British royal family has severe hemophilia, and when they marry the royal families of other countries, they give birth to children who also suffer from hemophilia, so it has been passed on, and more and more people have passed it on.

Because the disease was first identified in the British royal family, and both the queen and his children suffered from hemophilia, the disease eventually became known as the royal disease.

Because this disease was first spread among the royal family, ordinary people did not have the opportunity to inherit this disease, so it was called royal disease.

Because the original origin of this genetic disease was Queen Victoria, and then it ravaged European royal families, hence the name.