What are the causes of myasthenia gravis and what are the factors that cause myasthenia gravis?

Myasthenia gravis is a common condition, also known as severe weakness, is a chronic autoimmune disease, this disease will be **, can occur at any age, but more in children and adolescents, women account for the majority, patients often show that they are very easily fatigued, can not move at will, etc., so what is the cause of myasthenia gravis? I think everyone wants to know, don't worry, let's talk about it below.

Method steps.

Overwork, nervousness.

If the patient sits in front of the computer for a long time to play games, or plays mahjong for a long time, it will lead to myasthenia gravis, so we must ensure the combination of work and rest, and maintain a happy mood, which can prevent the disease well.

Genetic factors. Myasthenia gravis is also a disease that has a lot to do with genetic factors, so if you have a history of this disease in your family, you must be vigilant and go to the hospital regularly for check-ups to see if you have myasthenia gravis.

Viral infections. Myasthenia gravis is also very related to thymic lentivirus infection and low immune function, so everyone should strictly prevent the occurrence of colds and often do physical exercise to enhance their own resistance.

Food poisoning and contamination.

There are many patients who are infected with myasthenia gravis after eating unclean fried fritters or drinking low-quality drinks contaminated with chemicals, which is one of the most common causes of myasthenia gravis.

Nutritional factors. Most patients with myasthenia gravis have difficult family conditions, which may be related to long-term nutritional deficiencies or long-term fatigue, which may also lead to myasthenia gravis.

Autoimmune abnormalities.

Clinical studies have found that many immune indicators in patients with this disease are abnormal, and the clinical symptoms disappear after menstruation, but the abnormal immune indicators do not change, which may be an important factor in the instability and ease of the disease.

1. Abnormalities of the autoimmune system 2. Genetics.

This kind of disease will be **, which is caused by the abnormality of the immune system and is also hereditary.

All sorts of reasons can arise.

Myasthenia gravis is an autoimmune disease that, like other autoimmune diseases, is caused by a disorder of the body's immune system that disrupts the body's normal "order". Myasthenia gravis is the attack of acetylcholine receptors in the postsynaptic membrane of the neuromuscular junction by autoantibodies, and when the function of this important receptor is abnormal, it will directly affect the normal conduction and action of neuromuscles.

1. Myasthenia gravis has physical factors; Endocrine disorders, hyperthyroidism and other diseases can cause myasthenia gravis.

2. External environmental factors, such as environmental pollution, can cause a weakened immune system; Overwork causes the body's immune function to be disordered; Certain genetic defects are induced by viral infections or the use of certain antibiotic drugs.

3. Mental factors: Excessive fatigue occurs due to playing mahjong and computer games for a long time, so it is necessary to combine work and rest to maintain a comfortable mood. It is one of the ** myasthenia gravis.

Fourth, the patient's own immune system is abnormal, clinical studies have found that many immune indicators in the patient with this disease are abnormal, and the clinical symptoms disappear after the first pass, but the abnormal immune indicators have not changed, which may be an important factor in the instability and ease of the disease.

Myasthenia gravis is only one immune disease, which is caused by problems with the body's immune system, which disrupts the normal order of the body.

It may be that you exercise regularly, or you may have done some tiring work. It is possible that the muscles are damaged, which is why this happens.

It may be that the immune system is declining, or there may be a problem with the body, in this case, you must go to the hospital for examination in time.

Myasthenia gravis is an autoimmune disease at the neuromuscular junction. Nerve impulses travel to nerve endings, which release a transmitter called acetylcholine. Acetylcholine binds to acetylcholine receptors on the muscle muscle membranes, giving instructions to the muscles to contract, relax, or contract and relax harder.

After autoimmune disorders, antibodies to acetylcholine receptors in the postsynaptic membrane will be produced, so that acetylcholine receptors will be destroyed and reduced, and the receptors bound to acetylcholine will be reduced, and the instructions to the muscles will be reduced, and the impulses of the muscles will also be reduced, which can cause muscle weakness, and in severe cases, it can cause muscle atrophy, which is myasthenia gravis. The exact cause of the autoimmune disorder is not well understood, and further research is needed.

The cause of myasthenia gravis is not clear, and it is generally divided into two categories, one is congenital inheritance, which is basically very rare. The second type is autoimmunity, which is the most common, and it is now generally believed that it is related to infections, drugs, and environmental factors.

Myasthenia gravis is an autoimmune disease, and like other autoimmune diseases, the main cause of the disease is a disorder of the body's immune system that disrupts the normal "order" of the body. Myasthenia gravis is the neuromuscular junction of the postsynaptic membrane acetylcholine receptor is attacked by autoantibodies, and when the function of this important receptor is abnormal, it will directly affect the normal conduction and action of the neuromuscular body.

Disorders of the body's immune system are generally related to environmental factors, infection factors, drug factors, etc., but the specific causes of myasthenia gravis are not clear. Patients with myasthenia gravis often have other autoimmune diseases such as hyperthyroidism, thyroiditis, systemic lupus erythematosus, rheumatoid arthritis, and pemphigus.

1. In recent years, according to ultrastructural studies, myasthenia gravis is mainly caused by the lesion of acetylcholine receptor (ACHR) in the postsynaptic membrane.

2. Many clinical phenomena also suggest that the disease is related to the disorder of the immune mechanism.

3. Myasthenia gravis is an autoimmune disease that affects the transmission of neuromuscular junctions, and its exact pathogenesis is still unclear, but there are still many studies on the disease, among which, the most studied is the relationship between myasthenia gravis and thymus, and the role of acetylcholine receptor antibodies in myasthenia gravis, and a large number of studies have found that the number of acetylcholine receptors (ACHR) on the postsynaptic membrane at the neuromuscular junction in patients with myasthenia gravis is reduced, and there are anti-ACHR antibodies at the receptor site. and the deposition of IgG and C3 complexes on the postsynaptic membrane.

It has also been shown that the increase in anti-ACHR antibodies in the serum and the decrease in the number of effective ACHR caused by the deposition on the postsynaptic membrane are the main causes of the disease. The thymus gland is the main site of ACHR antibody production, so the occurrence of this disease is generally closely related to the thymus. Therefore, regulating the number of ACHR in the human body, increasing its number, resolving the deposition on the collapsed membrane of the postsynaptic trace, and inhibiting the production of anti-ACHR antibodies are the key to this disease.

Pathological diagnosis of myasthenia gravis.

The pathological morphology of myasthenia gravis includes three parts: muscle fibers, neuromuscular junctions, and thymus.

1. Changes in muscle fibers: In the early stage of the disease, there are mainly lymphocyte infiltrates between muscle fibers and around small blood vessels, mainly small lymphocytes, which is called lymphatic leakage; In acute severe disease, there is coagulative necrosis of muscle fibers, accompanied by macrophage exudation of polymorphonuclear leukocytes; In advanced stages, muscle fibers may have varying degrees of optic nerve changes, and the muscle fibers are small.

2. Changes at the neuromuscular junction: The morphological changes at the neuromuscular junction are the most characteristic changes in the pathology of myasthenia gravis, which are mainly manifested in: the postsynaptic membrane fold disappears, flattens, and even breaks.

3. Changes in the thymus: about 30 patients with myasthenia gravis have thymoma, 40 to 60 patients have thymus hypertrophy, and more than 75 patients have central hyperplasia of thymus. Adenomas are classified according to their cell type:

Lymphocytic, epithelial, and mixed with the fine form of tardinocytic type, the latter two are often associated with myasthenia gravis.

We found the lesion in the head. s4487