Can it come back after a bone marrow transplant? Is a bone marrow transplant risky?

Whether or not you will be able to do it after transplant depends on a variety of factors, such as the type of disease, the state of the disease before the transplant, the transplant method, and the post-transplant tests.

1. Types of diseases: Generally speaking, chronic myeloid leukemia is the best transplantation effect in leukemia, with 5-year DFS of about 60-80%, acute leukemia 5-year DFS of 40-80%, early aplastic transplantation of 5-year DFS 60-80%, and thalassemia transplantation as long as post-transplant related complications are passed. However, the ph chromosome positive acute shower is not very effective.

2. Disease status before transplantation: Leukemia, lymphoma, myeloma and other hematological tumors and livelihood diseases should be transplanted after systemic chemotherapy when the tumor cells are the least, and the rate is small, otherwise the rate is extremely high.

3. Transplantation method: Generally speaking, compared with bone marrow transplantation and umbilical cord blood transplantation, the rate of peripheral hematopoietic stem cell transplantation is smaller.

4. Post-transplantation testing: After transplantation, if you can regularly recheck the small residual lesions (such as slow grains can detect fusion genes), detect the first signs early, and take active remedial measures can also improve the efficacy and reduce the chance.

It is possible that it is mainly related to the incomplete clearance of leukemia cells during bone marrow transplantation, that is, there are more leukemia cells remaining in the body, and the graft does not have a strong anti-leukemia effect after bone marrow transplantation.

There is a certain amount of risk.

1. What are the risks of bone marrow transplantation?

1. Rejection reaction.

Although bone marrow transplantation has a good effect on leukemia, the rate of bone marrow transplantation is only 50 60%, and it cannot guarantee the length of life of patients, because patients who receive bone marrow transplantation may have severe rejection, which is easy to accelerate the death of patients.

2. Reduce immunity.

During the process of receiving a bone marrow transplant, the doctor will reduce the rejection by destroying the patient's immunity, so as to achieve the best goal of a successful transplant. If the body's immunity becomes low, the patient's resistance to other diseases will also decrease, so it is easy to suffer from other diseases.

2. What are the dangers of bone marrow donation to the body?

1.Significant backache.

Generally, most of the volunteers who donate bone marrow are young people, because young people have better physique, and basically after choosing to donate bone marrow, there will be no physical problems. However, if an elderly person chooses to donate bone marrow, it is likely that they will have backache and at least need to recuperate for a long time before they can return to their original state.

2.Dizziness.

Bone marrow transplantation is actually to extract some bone marrow hematopoietic stem cells from normal human bodies to save some patients, bone marrow transplantation can save the lives of patients with leukemia, but for donors, it will not have an impact, because bone marrow is a substance that can be regenerated by the empty seeds, but there will be obvious dizziness after donation, and more iron needs to be supplemented at this time.

After bone marrow transplantation** is one of the important factors affecting the outcome of bone marrow transplantation. It reduces the long-term survival rate of bone marrow transplant** leukemia and is a major life-threatening problem for patients after bone marrow transplantation. The rate of leukemia after allogeneic bone marrow transplantation is about 20 30.

Leukemia** is mainly caused by incomplete clearance of leukemia cells during bone marrow transplantation. That is, the large number of leukemia cells remaining in the body is related to the weak anti-leukemia effect of the graft after bone marrow transplantation. Currently, research on leukemia by detecting minimal residual disease after bone marrow transplantation is being explored.

Improving the pretreatment regimen for bone marrow transplantation, strengthening leukemia patients before bone marrow transplantation, selecting the best timing for bone marrow transplantation, and inducing the graft leukemia effect may be helpful in reducing the incidence of leukemia after bone marrow transplantation. In leukemia** after bone marrow transplantation**, for acute leukemia, remission is generally first induced by chemotherapy, followed by a second bone marrow transplant, and in some cases, a second bone marrow transplant can be performed directly without induction of remission.

For patients who are in poor condition and are not expected to tolerate a second bone marrow transplant, only supportive and symptomatic can be done. The rate of re-induction of remission after bone marrow transplantation** is 50 in acute lymphoblastic leukemia and even lower in acute myeloid leukemia. In patients who have undergone a second bone marrow transplant**, the long-term disease-free survival rate is only about 10.

It can be seen that the treatment of leukemia after bone marrow transplantation is quite difficult. For patients with chronic myeloid leukemia after bone marrow transplantation, the method of injecting interferon combined with transfusion of peripheral blood lymphocytes from donors has been able to achieve "**" (malignant clone disappearance) in some patients. If this method is not effective, drugs such as hydroxyurea can also be used to control the condition, but the most active and effective method is still a second bone marrow transplant.

There is a possibility of **, generally within three months, the chance is larger, and the chance after 2 years is only 10%.

It is possible and not uncommon for patients to have a successful bone marrow transplant, especially if the bone marrow transplant is genetic. Before bone marrow transplantation, chemotherapy drugs should be used to kill all the leukemia cells in the patient's body, and bone marrow suppression will also occur.

The most important thing is chemotherapy before transplantation, which can be strengthened and consolidated by the "@齐凤急性癌变的心路" method.

The success rate of transplantation is related to many factors such as the patient's age, disease status, donor, and HLA compatibility.

Generally, the probability of successful removal of blind mold implantation should be more than 95%;

After successful transplantation, there is still about 20% ** rate, which is related to many factors such as disease state;

The cost is also related to the above factors, and whether there are serious complications, and it may be a little different from hospital to hospital, and if it is successful, the transplantation of HLA compatible compatriots in this hospital is about 200,000 yuan.

Wang Jianmin, Shanghai Changhai Hospital.

**Standard: If it is after acute leukemia remission, five years are not **, we call it long-term survival, ten years are not**, we call **. But there are some special cases, such as having acute lymphoid leukemia when I was a child, and then ** more than ten years later.

Speaking of acute leukemia, whether it is acute lymphoblastic leukemia or acute myeloid leukemia, about 20% to 30% of patients who rely on chemotherapy can **, that is, reach the situation of not ** for ten years. If a bone marrow transplant is available, the rate will be higher. But chronic leukemia, so far, if you don't go for an allogeneic hematopoietic stem cell transplant, we haven't said that you can make it by chemotherapy or other **.

Acute depends on drugs** a considerable part of **, but chronic, to this day I dare not say which drug can ** leukemia. There are mainly the following types of chemicals: radiation, targeting, and traditional Chinese medicine. Some high-risk patients require bone marrow transplantation.

In the past 10 years, with the progress of molecular biology and biogenetics, the prognosis of leukemia has been greatly improved. "Leukemia is an incurable disease" is a thing of the past. Formally, systematically** can enable most leukemia patients to survive without disease for a long time, or even be cured.

Bone marrow transplantation is theoretical, but it is difficult to control if it is not complicated by serious complications due to factors such as cost, toxicity, and related deaths caused by bone marrow transplantation.

It's been 10 years since my husband had her transplant. Now my body is better than mine. He had acute lymphoid leukemia L3. Science is evolving, and so is medicine. The main thing is to have a good mindset. Good luck to all.

In addition to getting married and having children, women have a lot to do, and there are many ways to prove their worth. Deng Yingchao, Song Qingling, and Yang Liping don't have children, but who doesn't respect their names when it comes to them? If you really like children, see her again after many years, very sunny, the voice is still as good as before, we also fought when we were children, and we feel very kind when we grow up, and now she is very healthy, except for a little fat, her children are several years old, and the children have inherited her good voice, as for the children, we plan to adopt, or step the children of younger brothers and sisters in the future.

If these two paths don't work, there's nothing wrong with the two of them relying on each other.

<> person is a very contradictory individual, when you can have a child normally, but because you are afraid of the pain of giving birth or do not know how to take care of the child, you hesitate to have a child, or decide not to have a child, or dare not have a child after giving birth. You are a lucky girl with a very low rate of leukemia and many unsuccessful even stem cell transplants. My son donated stem cells to a boy with leukemia in 2017, and the anxiety and despair of the boy's family will be remembered for the rest of my life.

I'm not pouring cold water on you, don't have children, I gave birth to a normal child and went to half my life! A person has a way of living alone, and if you want to have children very much, you can be with someone who has children! Or adopt!

After I gave birth to Dabao, my neighbors and relatives all said that while my mother-in-law was young, I would not be guilty of giving birth to a second child as soon as possible. At that time, I thought that Dabao was only two years old, and he would not have a second child after a few years of leisure. Then the baby was more than four years old and I was diagnosed with advanced breast cancer.

The three words leukemia are demons and plagues, and they are the last words I want to see in my life. The protagonist of the article: You have a leukemia transplant and can survive is a blessing in misfortune. As for not being able to have children, don't worry about it.

I was diagnosed with leukemia in early March this year, and I had a transplant in May, and it is now 100 days after the transplant. My aunt never visited me, and I wondered if I might not be able to have children in the future. But I was mentally prepared to have children in the future

Leukemia is completely ** after bone marrow transplantation, exactly the same as our normal people, and there are no sequelae, this disease can be completely **.

Most people have no sequelae after bone marrow transplantation**, but some people with a particularly strong immune system may have sequelae. Their immune system destroys the bone marrow by rejecting the transplanted bone marrow.

No, first of all, for leukemia, it is a blood disease, this disease is mainly diagnosed by bone puncture, this disease is highly prevalent among adolescents is to arouse our enough attention, in life to pay more attention, there are similar symptoms in time**.