James Allison of the United States, Yu Honjo of Japan, what are their contributions to the Medical P

Their main contribution is in the biological aspect, with the discovery of enzymes.

Their main contribution is in the molecular mechanisms by which the circadian clock operates.

They have made remarkable contributions in biology in terms of biomolecular mechanisms.

Creatures, their contribution to biology is unparalleled.

It has made great contributions to biomolecules, which indicates that people have made further progress in the study of biomolecules.

According to the latest news on the official website of Nobel, at 5:30 pm Beijing time on October 1, the Karolinska Institutet of Sweden announced in Stockholm that the 2018 Nobel Prize in Physiology or Medicine was awarded to American immunologist James P Allison and Japanese biologist Tasuku Honjo in recognition of the contributions of the two scientists in tumor immunology. They will share the prize money of 9 million Swedish kronor (about 6.95 million yuan).

James P Allison (left) and Tasuku Honjo (right) for their discovery of cancers that inhibit negative immunomodulation**. Allison is Professor and Chair of the Department of Immunology at the University of Texas MD Anderson Cancer Center and Director of the Scientific Advisory Board of the Cancer Institute (CRI). 2018 Nobel Laureate in Physiology or Medicine:

James P. Allison's research interests focus on the development and mechanism of T cells, and the development of new strategies for tumor immunity. Allison found that a protein called CTLA-4 on the molecular surface of immune cells acts as a "molecular brake" to terminate the immune response. Inhibition of CTLA-4 molecules can cause T cells to proliferate and attack tumor cells.

Based on this mechanism, the first cancer immunodrug, ipilimumab (for melanoma), was launched.

His findings offer a new direction for the deadliest cancers. Cancer, which kills millions of people every year, is one of humanity's greatest health challenges. Tasuku Honjo is currently a visiting professor at Kyoto University.

In 1992, he discovered the T cell inhibitory receptor PD-1, and in 2013, he pioneered cancer immunity**, which is ranked first among the top ten scientific breakthroughs of the year by Science, and he is also the winner of the "Koho Prize" of the Rob Koho Prize, the highest award in German medicine. 2018 Nobel Prize in Physiology or Medicine: Tasuku Honjo This is the 109th Nobel Prize in Physiology or Medicine since 1901, and a total of 216 people have been honored.

So far, <>

Twelve women have received the award. The youngest recipient was Frederick for the discovery of insulin), while Peyton Rous, who was awarded for the discovery of tumor-inducing viruses, was 87 years old when he won the award in 1966, making him the oldest ever recipient. Cancers with negative immunomodulation have revolutionized cancer and fundamentally changed the way we think about how cancer is.

These two scientists have made great contributions to tumor immunology.

They must have achieved a high level of achievement in the relationship between molecules and organisms.

Their research on biomolecules is very good.

I think it's the molecular mechanism of their biological clock, and it's been well studied.

In 1992, he discovered the T cell inhibitory receptor PD-1, and in 2013, he pioneered cancer immunity**, which is ranked first among the top ten scientific breakthroughs of the year by Science. Honshu is also known for the molecular identification of cytokines IL-4 and IL5, as well as the discovery of activation-induced cytidine deaminase, which plays an important role in class switching recombination and somatic hypermutation.

Yu Honjo is the winner of the "Koho Prize" of the Rob Koho Prize, Germany's highest award in medicine, and is known as "one of the closest Japanese people to the Nobel Prize". In 2014, he co-won the inaugural Tang Prize Biotechnology and Pharmaceutical Award with James Allison. On September 21, 2016, he was selected for the 2016 Citation Laureate Award.

On September 25, 2016, the 2nd Tang Prize Award Ceremony was held, and the winner of the first Tang Prize Biomedical Award, Yu Honjo, received the award. On October 1, 2018, the 2018 Nobel Prize in Physiology or Medicine was announced, and James Allison and Yu Honjo jointly received the award for their "contributions to the discovery of negative immunomodulatory cancers".

He invented a medicine that he said could ** so cancer. So won the Nobel Prize. said that within ten years, he would put the drugs he invented into all cancers.

The 2018 Nobel Laureate in Medicine is:James P. Allison of MD Anderson Cancer CenterwithJapanese immunologist Yu Honjo

Both of these gods are researchHow to fight cancerTarget. And now people are all discolored, so let's see what amazing things these two gods have done!

James P. Allison, the American god, a very cute fat paper, his first half of his life was small and transparent, and basically no one in that circle had heard of it, and by the beginning of 14 years, he was active in front of the public. On the fight against cancer, he foundNegative immunomodulation of cancer, cancer in the future, will no longer be a terminal disease.

The other is Japanese, calledYu Honjo, looks a little familiar. The man of God has been receiving awards since he was 35 years old (1978), and various awards are national and world-class, specializing in the immune system, discovering immunity**, and also fighting cancer.

In addition, this old professor often gives lectures in China, and medical students are blessed, and if there are exchange opportunities in China, they can also listen to his courses at the University of Tokyo and other institutions.

2018 yearNobel Prize in Physiology or MedicineThe winners are revealed. This year's winners of the award are:James Allison, an immunologist at the University of Texas at Austin（james p.allision) andProfessor Yu Honjo at Kyoto University in Japan(Tasuku Honjo) in recognition of their "discovery of cancer that inhibits negative immune regulation**".

James AllisonWhat is studied is a known protein that acts as a brake on the immune system. He realized the potential to release that brake and thus the body's immune cells to attack tumors. Subsequently, he developed this concept into a completely new approach for cancer patients.

Yu HonjoA protein on immune cells was discovered. After carefully evaluating its function, Honjo finally discovered that it could also be used as a brake, but with a different mechanism. Based on this finding**, it has been shown to be very effective in fighting cancer.

Allison and Honjo demonstrate how different strategies to suppress the immune system's brakes can be used for cancer**. The important discoveries of the two laureates constitute a milestone in the fight against cancer.

On October 1, 2018, at about 17:30 Beijing time, the results of the winners of the winners of the 2018 Nobel Prize in Physiology or Medicine were James P Alison, an American immunologist, and Tasuku Honjo, a Japanese immunologist, both of whom are experts in the study of immunology, and have worked hard for many years, especially in tumor immunity, to achieve new breakthroughs and make success** It is likely that cancer will no longer be a fantasy in the future, and this award was awarded for his wonderful contributions in the field of tumor immunology.

The roller coaster ride still has this effect?!

On October 2, 2017, at 5:30 p.m., the 2017 Nobel Prize in Physiology or Medicine was awarded to American scientists Jeffrey C. Hall, Michael Rosbashi and Michael W. Young for "their discoveries on the molecular mechanisms of the circadian clock".

On October 1, the 2018 Nobel Prize in Physiology or Medicine was awarded to American immunologist James Allison and Japanese biologist Professor Yu Honjo for their contributions to the field of immunology.

In fact, Professor Qian Qijun and Professor James Allison have jointly raised questions about cancer. The two sides share many common views on cancer**. For example, the Nobel Prize has shown favor in the field of immunology.

The Nobel Prize is awarded for his outstanding contribution to the acute infectious disease diphtheria**. In the more than 100 years since, advances in the field of immunology have won the Nobel Prize in Physiology or Medicine 14 times. This year, immunology has won the championship 16 times.

In fact, this lies in the fact that immunity can be said to be the "natural enemy" of most human diseases. Almost all diseases suffered by human beings are related to immunity. From smallpox vaccines to today's immunization, diseases that are considered "devils" and "terminal diseases" have made it possible.

Arguably the perfect vaccine.

In fact, it is because of the outstanding contribution made in cancer immunity**. PD-1 inhibitors, known as the "miracle drug for cancer", are a boon for patients on the road to anti-cancer. The first to discover this passage was Professor Yu Honjo.

The PD-1 pathway is an immune checkpoint inhibitor, which means that cancer cells in our body can inhibit the killing effect of T cells through these pathways, so that they can develop and grow in the body, and immune checkpoint inhibitors are used to kill cancer cells by blocking these pathways. A lot has been achieved.

It can be said that in the future, when adoptive cells overcome the target problem, it is very promising to win a Nobel Prize medal in the field of immunity again.

Because every time there will be new discoveries, it will be more advanced, which will be of great help to the medical career.

Because the recipients of this award have been of great help to mankind, and people have benefited greatly.

Immunology is also multi-purpose in medicine, and the Nobel Prize in the field of immunology has been awarded three times, because it has brought unprecedented contributions to the medical community.

There will be new breakthroughs every time, and there are no established results in academic research, only breakthroughs again and again!

The most important part of the immune system is to give people a huge medical help for the benefit of mankind.

Three times it shows that immunology has a very important impact on human life and disease.

Because the awards won are different, there are still many things that people have not overcome in medicine.

Because the medical help at that time was very great, and a lot of immunoscience research and development was developed.

Immunology is also versatile in medicine, and Nobel helped a lot in medicine.

It takes time for the results of research to prove their worth, so Nobel laureates need to be observed.

Because the Nobel selection team needs to see if the work can be developed for a long time.

Because it takes time for a research result to prove its prospects.

It's because the judges need time to witness and see if they are qualified.

Many research results need time to witness and see if they are valuable before they can be awarded.

It's because we need to see if this patent can be delayed forever, and it needs to be selected by the personnel of the award department.

Because many inventions need time to witness and see if they can develop for a long time.

Because only when we see that this achievement will not decline will there be value in awarding.

No one dares to draw conclusions about whether the research results will be successful, and only time will tell.

This year's award was given to two immunologists from the United States and Japan, who broke new ground in the medical community.

The 2018 Nobel Prize in Physiology or Medicine was awarded to American immunologist James Allison and Japanese immunologist Yu Honjo for breaking new ground in the medical community.

On October 1, 2018, at 09:30 GMT, the Nobel Prize in Physiology or Medicine was first announced at the Karolinska Institutet in Sweden.

Research can be traced back nearly 150 years ago, when two German clinicians, Busch W and Fehleisen F, tried to use infectious agents to activate the immune system in response to cancer in the 19th century.

Awarded to American immunologist James Allison and Japanese immunologist Yu Honjo.

Immunity** is far from perfect. These drugs may prolong the life of patients by several years, but only a small percentage of patients are so lucky. Who is better suited to use this **? Research is ongoing.

Immune cell brakes, or molecular brakes, have opened up new horizons for tumors.

It stimulates its ability to attack tumor cells to achieve the purpose of killing tumors.

In recognition of the contributions of two scientists in tumor immunology. The discoveries of these two scientists have led to a new concept.

William Kelling, Peter Ratcliffe, and Greg Semenza have already won the prize, and scientists who have contributed to science are expected to receive the prize.