What can chronic sleep deprivation cause, and what can sleep deprivation cause?

If you don't get enough sleep for a long time, you are likely to have difficulty concentrating and memory loss. It may affect our physical development, and long-term lack of sleep can cause people to be anxious and irritable. It is easy to lead to an increase in the content of cholesterol in the blood, thereby increasing the incidence of heart disease and cerebrovascular disease;

The dangers of long-term sleep deprivation are enormous.

Hurt the liver: Short temper and poor moodWhen people are focused on something, if they are interrupted, they will have negative emotions. Israeli researchers have found that sleep deprivation amplifies this negative emotion.

Nervousness: People who lack sleep will have weakened short-term memory, which will affect the learning effect. In addition, Italian studies have confirmed that it is difficult to concentrate without adequate sleep.

Lack of sleep can also make you unresponsive to external things. The less sleep you have, the more likely it is to have visual deviations, such as dark vision, inability to see, and even hallucinations.

Weakened immunity: People who don't sleep more than 7 hours a day for two weeks have 3 times the risk of catching a cold compared to people who sleep more than 8 hours. U.S. studies have found that sleep deprivation can easily cause inflammatory bowel disease; People with Crohn's disease (an intestinal disorder) have twice as much sleep as they don't get enough sleep.

Affects the brain's thinking: Lack of sleep can affect the flexibility of the brain's thinking, which may reduce productivity.

Long-term sleep deprivation can lead to a decline in brain function, a decrease in disease resistance, and a decrease in normal work and study.

1.Long-term sleep deprivation can lead to a decline in brain function, and patients can manifest as memory loss, inability to concentrate at work, decreased work efficiency, brain retardation, lack of energy and other adverse outcomes. In this case, increase sleep time and don't be a workaholic.

2.Decreased disease resistance: Long-term sleep deprivation can lead to decreased disease resistance and susceptibility to disease.

3.Affect normal work and study: Long-term lack of sleep will lead to lack of energy at work, fatigue, and decreased learning ability.

The impact of long-term sleep deprivation on the body is multifaceted, and in order to be healthy, it is necessary to maintain enough sleep time and achieve a combination of work and rest.

Long-term sleep deprivation leads to adverse results, and it is necessary to correct sleep habits in time, and it is also necessary to be active**. Long-term lack of sleep will lead to many problems in patients, such as malaise, sleepiness, and lack of concentration during the day, and long-term insomnia will lead to memory loss and resistance decline in patients, and they are prone to colds and pneumonia.

After a long period of insufficient sleep, women will cause endocrine disorders and lead to menstrual disorders, and the patient's ** will appear dull and dull. If the elderly have high blood pressure, heart disease, diabetes and other diseases, long-term poor sleep will adversely affect the control of these diseases. Therefore, patients with long-term sleep deprivation must be adjusted in time, from the aspects of lifestyle, psychological state, and medication.

Humans spend a third of their lives sleeping, including invertebrates such as flies, worms, and even jellyfish. Throughout evolution, sleep has been universal and essential for all organisms with a nervous system. However, have you ever wondered why we sleep?

In fact, scientists have been searching for answers for years. According to a new study published in the journal Molecular Cell on November 18, researchers at Bar-Ilan University in Israel have found that the PARP1 protein in the brain acts as an "antenna" that sends time signals to the brain to sleep and repair DNA damage, a discovery that is one step closer to solving this mystery.

When we are awake, the homeostatic sleep pressure in the body increases, and the longer we stay awake, the more stress this stress increases. During the few hours of waking hours, factors such as ultraviolet light, neuronal activity, radiation, oxidative stress, etc., can cause sustained DNA damage in neurons. However, excessive DNA damage in the brain can be dangerous, and sleep can "summon" the DNA repair system.

The characteristics of neural activity during sleep in zebrafish are similar to those of humans, and they are the subjects of sleep study. Through zebrafish experiments, researchers determined that the accumulation of DNA damage is a driving factor that causes sleep states. When the accumulation of DNA damage reaches the maximum threshold, the homeostatic sleep stress increases to the point where the urge to sleep triggers it, and the fish goes to sleep.

Subsequent sleep promotes DNA repair, which reduces DNA damage.

So, what are the mechanisms in the brain that tell us: where is it time to sleep? It was found that the PARP1 protein is part of the DNA damage repair system and is one of the first proteins to respond to rapid reciprocal reciprocation.

It flags the location of DNA damage in the cell and "recruits" all relevant systems to remove the DNA damage.

Through genetic and pharmacological manipulation, overexpression and knockdown (down-regulation) of PARP1 experiments have shown that increasing PARP1 not only promotes sleep, but also increases sleep-dependent repair. Conversely, inhibition of PARP1 blocks the signal for DNA damage repair. As a result, the fish are not fully aware that they are tired and therefore do not go into sleep mode, causing DNA damage to not be repaired in time.

The same results were validated in mice.

This new finding describes how to explain the "chain of events" of sleep at the single-cell level. This mechanism explains the link between sleep disorders, aging, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. The researchers believe that future research will be extended to more animals, from lower invertebrates to humans.