The substance toxicity of gentamicin, what is gentamicin used for

Categories: Healthcare.

Also, gentamicin and sea buckthorn dry emulsion taken orally together**what?

Analysis: Don't take it orally! The reasons are as follows, look at it gentamicin is a broad-spectrum antibiotic suitable for a variety of gram-negative bacilli.

Infections, such as E. coli, pneumobacterium, Proteus infection, etc. Its toxic reaction is to the auditory.

Damage to the muscles and kidneys can cause sudden toxic deafness.

4) Helicobacter pylori inhabits the mucus layer in the highly acidic environment of the stomach and is taken orally.

Gentamicin, the digestive tract only absorbs 3, this concentration can not kill Helicobacter pylori at all, if taken for too long, there is a risk of toxic deafness.

Gentamicin and sea buckthorn dry emulsion are used orally together for the adjunct of functional dyspepsia, gastric distension and pain caused by anorexia in children, loss of appetite, poor appetite, nausea and vomiting.

Gentamicin is an aminoglycoside antibiotic that is mainly used for bacterial infections, especially those caused by gram-negative bacteria. Gentamicin can bind to the 30S subunit of bacterial ribosomes and block bacterial protein synthesis.

Gentamicin is one of the few thermostable antibiotics and is therefore widely used in media configuration. The broad-spectrum antibiotic independently developed by China is one of the great scientific and technological achievements since the founding of the People's Republic of China. It began to be developed in 1967 and was successfully identified at the end of 1969, and was named "gentamicin", which means to celebrate the "Ninth National Congress" and celebrate the greatness of the working class.

Gentamicin [gentamicin, gentamycin] is extracted from the fermentation culture of the genus Monosporia in the family Actinomyceae, which is an alkaline compound and is a commonly used aminoglycoside antibiotic.

Effects of gentamicin:

Indications 1The product is suitable for neonatal sepsis, sepsis, central nervous system infection (including meningitis), urogenital tract infection, respiratory tract infection, gastrointestinal infection (including peritonitis), biliary tract infection, **, bone, otitis media, sinusitis caused by Staphylococcus (including penicillin-resistant (G) and methicillin-resistant strains); soft tissue infections (including burns), listeriosis;

2.When the product is used for severe central nervous system infections (meningitis, ventriculitis) caused by Pseudomonas aeruginosa or staphylococcus, intrathecal injection of the product can be used as an adjunct**;

3.This product is not suitable for the initial treatment of simple urinary tract infection, unless the pathogenic bacteria are not sensitive to other less toxic antibacterial drugs, and the product is ineffective against most species of streptococci (especially group D), pneumococci and anaerobic bacteria (such as Bacteroides or Clostridium);

4.The product can be used orally for intestinal infection or preparation before colon surgery, and can also be used for intramuscular injection of this product combined with clindamycin or metronidazole to reduce the infection rate after colon surgery.

It has antibacterial effect on gram-negative bacteria such as Escherichia coli, aerogenes, Klebsiella, Proteus mirabilis, some indole-positive Proteus, Pseudomonas aeruginosa, some Neisseria spp., certain unpigmented Serratia and Shigella. Among the gram-positive bacteria, Staphylococcus aureus (including -lactamase-producing strains) is sensitive to this product; Streptococcus (including Streptococcus pyogenes, pneumococcus, Streptococcus faecalis, etc.) are resistant to this product. Anaerobic bacteria (Bacteroidetes), Mycobacterium tuberculosis, rickettsia, viruses and fungi are also resistant to this product.

In recent years, due to the wide application of this product, drug-resistant strains have gradually increased, and the resistance rate of Pseudomonas aeruginosa, Klebsiella, Serratia and Indole-positive Proteus to this product is very high. 30 60 minutes after intramuscular injection of this product or 30 minutes after intravenous infusion (lasting 30 minutes) of the same amount of drug reached the peak of 4 8 g ml; The trough concentration is less than 2 g and t1 2 is the hour. Within 24 hours after the injection of this product, 40 65 drugs were excreted in the original form from the urine.

It is mainly used for systemic or local infections caused by gram-negative bacteria such as Escherichia coli, dysentery bacillus, Klebaibacterium pneumoniae, Proteus, Pseudomonas aeruginosa (ineffective for central infection). The article is from China Health World Network.

This product is suitable for neonatal sepsis, sepsis, central nervous system infection (including meningitis), urogenital tract infection, respiratory tract infection, gastrointestinal infection (including peritonitis), biliary tract infection, **, bone, otitis media, sinusitis caused by Staphylococcus (including penicillin-resistant (G) and methicillin-resistant strains); soft tissue infections (including burns), listeriosis; This product is used for severe central nervous system infections (meningitis, ventriculitis) caused by Pseudomonas aeruginosa or staphylococcus, and can be injected intrathecally with this product as an adjunct**; This product is not suitable for the initial treatment of simple urinary tract infection, unless the pathogenic bacteria are not sensitive to other less toxic antibacterial drugs, this product is ineffective against most species of streptococcus (especially group D), pneumococci and anaerobic bacteria (such as bacteroides or clostridial bacteria); This product can be used orally for intestinal infection or preparation before colon surgery, and can also be used for intramuscular injection of this product combined with clindamycin or metronidazole to reduce the infection rate after colon surgery.

**Fish disease, turtle disease! Anti-infective effect!

Indications: Antibacterial effect on gram-negative bacteria such as Escherichia coli, aerogenic bacillus, Klebsiella, Proteus mirabilis, some indole proteus, Pseudomonas aeruginosa, some Neisseria sapiens, some unpigmented Serratia and Shigella. Among the gram-positive bacteria, Staphylococcus aureus is sensitive to this product; Streptococci are resistant to this product.

Anaerobic bacteria, Mycobacterium tuberculosis, rickettsia, viruses and fungi are also resistant to this product. In recent years, due to the wide application of this product, drug-resistant strains have gradually increased, and the resistance rate of Pseudomonas aeruginosa, Klebsiella and Serratia and Indole-positive Proteus to this product is very high. It has a strong effect on Staphylococcus aureus and Escherichia coli, aerogenic bacillus, Proteus mirabilis, Pseudomonas aeruginosa and other bacteria.

It is suitable for neonatal sepsis, sepsis, central nervous system infections (including meningitis), urogenital tract infections, respiratory tract infections, gastrointestinal infections (including peritonitis), biliary tract infections, **, bones, otitis media, sinusitis, soft tissue infections (including burns), listeriosis, and listeriosis caused by sensitive bacteria.

Like other aminoglycosides, gentamicin exerts antimicrobial effects by interfering with bacterial protein synthesis. Gentamicin binds to 16SRNA on the 30S subunit of bacterial ribosome, interferes with the ligation of formyl-methionyl-tRNA to 30SRNA, and blocks the synthesis of bacterial proteins.

Gentamicin is used for sepsis, respiratory tract infection, biliary tract infection, purulent peritonitis, intracranial infection, urinary tract infection and bacillary dysentery caused by Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, dysentery bacillus, Klebsiella, Proteus and other sensitive bacteria. However, it is ototoxic

Naphazolin hydrochloride is used for the treatment of cold allergic rhinitis, inflammatory nasal congestion, acute and chronic rhinitis.

The third question is about dexamethasone?

Gentamicin belongs to the aminoglycoside class of antibiotics, which has strong nephrotoxicity and ototoxicity, and the main adverse reactions are as follows:

1.Ototoxicity. Its main manifestations are hearing loss, tinnitus and a feeling of fullness in the ears, and in severe cases, drug-induced deafness may occur, which is irreversible.

2.Nephrotoxicity. Its main manifestations are hematuria, proteinuria, decreased urine output, decreased frequency of urination, loss of appetite, extreme thirst, etc., and in severe cases, it can lead to renal function decline and is irreversible. It has a higher incidence than antibiotics such as tobramycin.

Other adverse effects include:

1.Systemic application combined with intrathecal injection causes leg twitching, rash, fever and generalized cramps.

2.Sometimes dyspnea (with respiratory depression), drowsiness, dizziness, and extreme weakness are also present.

3.Occasional anaphylaxis, severe anaphylactic shock is rare.

4.High doses of medication can easily cause edema.

5.Occasionally, ** itching, urticaria, etc., and the rash will subside quickly after stopping the drug.

6.Occasionally, it can cause anemia, leukopenia, granulocytopenia, thrombocytopenia, and hypotension.

7.A small number of patients may have changes in liver function.

8.Gastrointestinal reactions such as nausea, vomiting, bloating, etc.

9.Long-term use can destroy the normal flora of the human body, leading to the overgrowth of insensitive microorganisms, causing multiple infections.

10.For the fetus, gentamicin also has a strong teratogenic effect.