Dosage of lamotrigine tablets, instructions for lamotrigine

Weighing 85 kg How to eat.

Aliases] lamotrigine, libitanyou lead, lamiktor.

Foreign name] lamotrigine, lamictal

Indications] Epilepsy (simple partial seizures, complex partial seizures, secondary and primary generalized tonic-clonic seizures) can also be used for seizures with Lennox-Gastaut syndrome.

Dosage and usage] 1st and 2nd week of people over 12 years old: 25mg qd; Weeks 3 and 4: 50 mg once a day; Maintenance dose:

100 200 mg once a day or in 2 divided doses. Adding** (Sodium valproate) 1st and 2nd week over 12 years old: mg once a day or 25mg every other day; Week 3 & 4:

25mg qd ；Maintenance dose: 100 200 mg once a day or in 2 divided doses. Add ** (without sodium valproate) 12 years old and above 1st and 2nd week:

50 mg qd；Weeks 3 and 4: 100 mg in 2 divided doses; Maintenance dose: 200 400mg in 2 divided doses.

Adding** (with sodium valproate)2 12-year-old children 1st and 2nd week: qd; Weeks 3 & 4: QD; Maintenance dose:

1 5 mg kg once a day or in 2 divided doses. Adding** (without grinding with sodium valproate)2 12-year-old children 1st and 2nd week: 2 mg kg divided doses; Weeks 3 & 4:

5mg kg divided into 2 doses; Maintenance dose: 5 15mg kg divided into 2 doses.

Adverse reactions] The main rash is present, and rarely severe rashes can occur, including angioedema and Stevens-Johnson syndrome. Others include headache, fatigue, nausea, dizziness, drowsiness, and insomnia.

Precautions] Patients with impaired liver and kidney function and pregnant women should use with caution. Monotherapy is not recommended for children under 12 years of age**. Patients should be at least 2 years old when used to add **.

Drug Interactions].

Antiepileptic drugs that can induce hepatic drug metabolism enzymes (such as phenytoin, carbamazepine, phenobarbital, and primecinone) will accelerate the metabolism of this drug; Sodium valproate can inhibit liver drug metabolism enzymes, so it will reduce the metabolism of this drug.

Specifications】 Tablets 25mg, 50mgx 30 tablets. 100mgx 30 tablets.

First: the results of large-scale mutagenicity tests show that this drug has no genetic danger to humans. In long-term studies in large and mice, this drug has no carcinogenicity.

Second: [Adverse reactions] In the trial of this drug as a single agent**, adverse reactions were reported including headache, tiredness, rash, nausea, dizziness, drowsiness and insomnia. In clinical double-blind, add-on trials, the incidence of rash was as high as 10% in patients taking lamotrigine and 5% in patients taking placebo.

2% of patients discontinue lamotrigine due to rash**. This rash is generally maculopapular in appearance and usually appears in the first 8 weeks of the first 8 weeks of ** and disappears after lamotrigine is stopped. Rare, severe rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell syndrome), have been reported, and rare cases associated with death have been reported.

The overall risk of developing a rash is strongly related to the following: the initial dose of lamotrigine is too large and the escalation of lamotrigine** above the recommended dose; At the same time, sodium valproate can increase the average half-life of lamotrigine by nearly 2 times. The rash has also been reported as part of an allergic syndrome with multiple forms of systemic symptoms, including fever, lymphadenosis, facial edema, and blood and liver abnormalities.

The severity of the clinical response caused by this syndrome varies greatly. Diffuse intravascular coagulation (DIC) and multi-organ failure are rare. Even if the rash is subtle, it is important to be aware of early manifestations of anaphylaxis (eg, fever, lymphadenosis).

If signs and symptoms of early reaction appear, the patient should be evaluated immediately; If it is not certain that there is another **, this drug should be discontinued. Other adverse effects when lamotrigine is added to standard antiepileptic regimens include diplopia, blurred vision, conjunctivitis, dizziness, drowsiness, headache, tiredness, gastrointestinal disturbances (including vomiting and diarrhoea), agitation-aggressive behavior, ataxia, anxiety, confusion, and hematologic abnormalities (including leukopenia and thrombocytopenia).

Contraindications] It is contraindicated in patients who have been allergic to lamotrigine.

Third: [Medication Instructions] In order to ensure the maintenance of the first dose, the weight of the sick child should be monitored; Check the dose when weight changes. If the child dose calculated based on body weight is not a whole number of tablets, the dose used should be rounded off to the whole number of tablets.

For children aged 2 to 12 years, there are insufficient data available in studies of children to recommend the dose of monotherapy** for children under 12 years of age.

It varies from person to person, it is not easy to eat raw and cold food, exercise properly, do not be overly tired, pay attention to rest, do not exercise vigorously, and drink more water.

It is contraindicated in patients who are known to be allergic to fissure lamotrigine and any of the ingredients in this product.