How does Parkinson s develop? What causes Parkinson s disease?

The exact cause of Parkinson's disease has not yet been determined. Genetics, environment, aging, oxidation, stress, etc., may all participate in the pathogenesis of Parkinson's disease. 1. Aging.

Because the incidence and prevalence of Parkinson's disease increases with age, it suggests that aging is associated with morbidity. 2. Genetic factors. The role in the pathogenesis of Parkinson's disease has received more and more attention from scholars.

There are currently at least six pathogenic genes associated with familial Parkinson's disease. Genetic factors are only one of the factors in the development of Parkinson's disease.

Except for a small proportion of familial Parkinson's disease, which is caused by the disease-causing gene, the vast majority of Parkinson's disease is sporadic Parkinson's disease, with no clear family history and fatal genes. The complexity of sporadic Parkinson's disease is caused by a combination of internal and external factors, including genetics, environmental toxicants, aging, etc.

PD is a neurodegenerative disease with the substantia nigra-striatum pathway as the main pathway. At present, the cause of its pathogenesis is not clear, and its pathogenesis mainly includes: 1. Oxidative stress and free radicals damage substantia nigra cells and basal ganglia, and part of the damage may be the body's own metabolites; 2. The products produced by environmental toxicants and metabolic disorders damage the nigra stretatum; 3. May be related to genetic predisposition; 4. Accelerated aging, the number of substantia nigra cells decreases faster than normal people.

1. Age factor.

From the current clinical medicine, it can be found that the reason for the occurrence of Parkinson's syndrome disease is mainly because of environmental factors or age factors, and the gradual increase in age will also increase the chance of suffering from Parkinson's syndrome, such as frequent exposure to chemicals containing trace elements in life, which will also increase the chance of suffering from such diseases.

2. Drug factors.

If you regularly take phenothiazines in your life, in this case, you will gradually increase the number of drugs for Parkinson's syndrome, so you must pay attention to it. Therefore, when taking medicines, you must also be under the guidance of a doctor, and you should not take drugs indiscriminately.

3. Mental factors.

Mental factors are also a key to increasing Parkinson's disease, Parkinson's people will also have obvious depression, a long-term state of depression, to a certain extent, will also lead to the health of the body to an impact, although the increase in age is inevitable, but with the gradual increase of age, it is also necessary to control the mood, so we must do a good job of prevention, if there is often nervousness or fear and other adverse diseases, it will also lead to severe tremors in patients, It can also lead to a more severe condition.

Fourth, hereditary factors.

There are also medical circles that the reason for the occurrence of Parkinson's syndrome is mainly due to genetic factors, because the disease itself has a genetic tendency, and if someone in the close relatives has Parkinson's disease, then the probability of suffering from such diseases in the close relatives is relatively higher than that of ordinary people.

Parkinson's disease is a serious disruption to daily life, what are the causes of Parkinson's disease? Parkinson's disease is a chronic disease, and modern science is not fully sure of its details, and many of the factors known to cause Parkinson's disease are as follows:

1. Illness or complications.

Parkinson's disease itself is a multi-disease disease that can manifest itself throughout the body. Many patients often develop other diseases that cause symptoms of Parkinson's disease. Modern science believes that Parkinson's disease is caused by a decrease in dopamine substances in the brain, and it has been reported that some patients gradually develop severe and persistent Parkinson's disease syndrome after suffering from Alzheimer's disease, alpha encephalitis and other diseases.

In the early stages of Parkinson's disease, it can also cause loss of smell and constipation. These are also the harbingers of most Parkinson's patients.

2. Caused by drug poisoning.

Western medicine is the most prevalent method, and since Parkinson's disease is a chronic condition that can last for more than a decade, it is necessary to take long-term medication to maintain symptoms. Western medicine has obvious *** of its own. It has been reported that a very large number of Parkinson's disease patients have an acute history of poisoning, followed by diffuse symptoms of brain damage, including mild tremor and general rigidity, which is also a factor in Parkinson's disease.

3. Caused by cerebral arteriosclerosis.

Cerebral arteriosclerosis as a common disease in the elderly, is also one of the key factors causing Parkinson's disease, cerebral arteriosclerosis sometimes promotes lacunar cerebral infarction in the brainstem and basal ganglia, which will interfere with the substantia nigra dopamine striatal pathway, such patients will have tendon hyperreflexia and pseudobulbar palsy, many Parkinson's patients will have more prominent dementia symptoms in the second half of the period, which looks like Alzheimer's disease, therefore, the occurrence of cerebral arteriosclerosis must be paid more attention and timely response.

From the point of view of chemopathology as far as is known, patients with Parkinson's disease have a decrease in striatal dopamine. Some cases may be degeneration of dopaminergic nigra striatal neurons, others may be a decrease in dopamine receptor-containing neurons in the striatum, and still others may be pharmacological depletion of striatal dopamine or dopamine receptor blockade. From a pathoanatomical point of view, neuropathologists generally agree that the selective loss of pigmented neurons in the brain of patients with Parkinson's disease (particularly in the dense parts of the substantia nigra) is the most constant presentation.

Similar changes are found in the locus coeruleus and vagus dorsal motor nuclei. From a biochemical point of view, it is a primary dopamine deficit due to a lesion or injury to the dopamine nervous system. The physiological role of the dopamine nervous system is to counteract the excitatory cholinergic activity in the striatum, which is one of the inhibitory modulation mechanisms of the striatum.

The striatum contains a large amount of acetylcholine. In a normal healthy state, there is a balance between the effects of acetylcholine and dopamine. At the onset of Parkinson's disease, dopamine decreases, acetylcholine concentrations do not change, and the equilibrium is disrupted and cholinergic activity predominates.

However, it is uncertain whether the decrease in dopamine is the only deficiency and whether it is the only basis for all manifestations of Parkinson's disease. Don't be afraid if you have Parkinson's disease, you have to believe in the current medicine, and mood regulation is very important. It is recommended that you use the Parkinson's device, my relatives are using it, the effect is really good, it uses non-interventional, safe and effective, no risk, no ***, breaking through the limitations of Parkinson's disease mainly relying on drugs and surgery, and can achieve the efficacy of a brain pacemaker, which is equivalent to a human in vitro brain pacemaker.

Parkinson's disease is a common slow-progressing neurodegenerative disease that occurs in middle and old age. Its main pathological change is the degeneration of dopaminergic neurons in the substantia nigra compacta, in order to elucidate the ** and pathogenesis of dopaminergic neurons in the substantia nigra. Experts in the Department of Neurology have carried out long-term, extensive and in-depth exploration and research.

Although there are many theories and hypotheses, the cause of Parkinson's disease is still unknown. The research progress in recent years can be summarized as follows:

1. Oxidative stress and mitochondrial dysfunction. Clause.

2. Abnormalities in apoptosis and immunology. Clause.

3. Toxic effects of nerves. Clause.

Fourth, genetic susceptibility means that there are certain genetic factors. The other is the exposure to environmental factors and toxicity, and the acceleration of human aging. There is no convincing evidence for any single cause of all of these causes, so it is believed that there are many interconnections that lead to the death of dopamine cells in the substantia nigra of the brain.

So the ** of Parkinson's disease is not clear.

Parkinson's is a disease that the elderly are more prone to, and there are many reasons for this disease, and it is currently believed that carrying certain genes will lead to the peak of Parkinson's disease, and some environmental factors will also induce the occurrence of Parkinson's disease.

Parkinson's disease (PD), also known as parkinson's paralysis, is a common degenerative disease of the nervous system in middle-aged and elderly people, mainly in the substantia nigra and striatum, and is the fourth most common neurodegenerative disease in the elderly.

Parkinson's disease mainly affects the motor nervous system, and its symptoms usually appear slowly over time, the most obvious symptoms in the early stage are tremors, limb stiffness, decreased motor function and gait abnormalities, and there may also be cognitive and behavioral problems, and other symptoms that may be accompanied include perception, sleep, and mood problems, and the main motor symptoms caused by Parkinson's disease are collectively called Parkinsonism syndrome.

There are three types of Parkinson's, and the main contents are as follows:

1. Parkinson's disease: It refers to Parkinson's disease, which refers to Parkinson's disease, such as resting tremor, increased muscle tone, abnormal posture and gait, etc., but the cause cannot be found by MRI examination of cardiovascular and cerebrovascular diseases. At present, the cause of Parkinson's disease is not clear, and it may be caused by a combination of reasons, such as a decrease in neuronal transmitters, and at this time, supplementation of transmitters**, such as medopa and levodopa, can improve the symptoms of Parkinson's disease patients by supplementing neuronal transmitters.

Receptor modifiers such as senfrol and teshuda (piribedil extended-release tablets) can improve Parkinson's symptoms through mobile receptors. Parkinson's disease is usually more common in patients over the age of 50, especially the older the disease, the higher the incidence of Parkinson's disease. Some patients with early-onset Parkinson's have a positive family history, such as a large number of people with Parkinson's symptoms in their 30s and 40s, and there are genetic abnormalities at this time;

2. Parkinson's syndrome: refers to recurrent cerebrovascular diseases such as cerebral infarction, cerebral hemorrhage, poisoning factors such as gas poisoning, pesticide poisoning or heavy metal poisoning, and long-term use of antipsychotics. These causes can cause parkinsonian symptoms such as resting tremor, dyskinesia, dystonia, and postural abnormalities;

3. Parkinson's superposition syndrome: In addition to the damage to the extrapyramidal system, other systems are also damaged. For example, in the case of multiple system atrophy, in addition to extrapyramidal Parkinson's symptoms, the autonomic nerves are also impaired, often due to neurodegeneration.

Parkinson's diagnosis and treatment is to help us solve these problems with TCM recuperation. If you need control, then use Western medicine, otherwise you use Chinese medicine to help you recover and fight.

Traditional Chinese medicine to Parkinson's: First of all, we often say that "Parkinson's is old age and body weakness", so what is body deficiency. Traditional Chinese medicine refers to the weakness of the constitution as body deficiency, the weakness of chronic diseases as deficiency syndrome, and divides the weakness into four types: qi deficiency, blood deficiency, yin deficiency, and yang deficiency.

The five organs all have the symptoms of yin and yang deficiency and reality, and Parkinson's is mainly what Chinese medicine calls "blood deficiency and wind.""Abbreviated as "Wind Certificate".

Shu Zhen and stop trembling**": extinguish the liver wind and relieve spasms, nourish the kidneys and replenish the brain and marrow, activate the meridians to make the meridians smooth, regulate the spleen so that nutrition can reach the whole body and relieve spasms. The causes of Parkinson's vary from person to person, and there will be additions and subtractions according to each person's different conditions.

Parkinson's disease (PD), also known as parkinsonism, is one of the most common neurodegenerative diseases. ** and the pathogenesis is not clear, and may be related to social factors, drug factors, patient factors, etc.

For patients, it is mainly from reducing pain, delaying the development of diseases, and improving the quality of life of patients.

Rational use of drugs and physiotherapy to control or alleviate symptoms and prevent secondary dysfunction; Actively engage in motor function training to improve movement, balance and coordination; Actively engage in homework** and speech training to maintain or improve the ability to perform activities of daily living.

One is to rest well, and the other is to replenish the protein needed by the body.

If it is not cured, it can only be stabilized with drugs.

1. Genetic inheritance.

According to clinical studies, Parkinson's disease has a certain familial genetic predisposition, and if there are patients with the disease in the family, the chance of developing the disease in the offspring will be greatly increased. The disease may be caused by a common nuclide gene or chromosomal mutation, mainly related to some central nervous system degeneration, which may be a genetic mutation or chromosomal variation.

2. Caused by aging.

Parkinson's disease is mainly affected by middle-aged and elderly people, and the disease generally occurs after the age of 40. This suggests that the disease is indistinguishable from aging, and may be due to changes in the activity of dopaminergic neurons in the substantia nigra or abnormal levels of tyrosine oxidase and dopa decarboxylase. However, age is only a major contributing factor to Parkinson's disease, not a direct trigger.

3. Caused by adverse environmental factors.

The occurrence of Parkinson's disease varies from region to region. If the human body is exposed to a polluted environment for a long time, especially if it contains certain toxic substances such as carbon monoxide and manganese, it will cause damage to brain neurons and cause disease.

Fourth, caused by improper medication.

Some diseases may be related to inappropriate medication. Long-term use of large amounts of dopamine receptor blockers such as mesylate and pergolide increases the likelihood of Parkinson's disease.

Therefore, there are many causes of Parkinson's disease, but it is often not caused by one factor, and may be the result of a combination of triggers, so it is best for patients to do CT, MRI and other examinations in time to be able to choose targeted treatment.