What factors may be related to the symptoms of advanced pulmonary fibrosis?

There are many classifications of pulmonary interstitial fibrosis, which are divided into two categories: known and unknown, and the onset of the disease is insidious, and the disease develops rapidly.

Among the known forms of pulmonary fibrosis, the most common ones are infections, occupational environmental factors, drugs, radiation, and connective tissue disorders. For example, inorganic dust including silica, asbestos, talc, antimony, aluminum, coal, beryllium, barium, iron, etc. Infectious**Infections with fungi, viruses, and atypical pathogens.

Drug factors include amiodarone, bleomycin, methotrexate, etc. Connective tissue disorders such as rheumatoid arthritis, polymyositis, dermatomyositis, Sjögren's syndrome, and systemic lupus erythematosus can also cause interstitial pulmonary fibrosis. Radioactive factors, on the other hand, usually refer to the radioactivity** of the tumour (referred to as radiotherapy).

Long-term high-concentration oxygen therapy can also cause pulmonary interstitial fibrosis.

The mechanism of pulmonary fibrosis is unknown**, and risk factors include smoking and environmental exposure. Relatively high-risk industries such as timber, metal mines, and metal product manufacturing can be uncertainties. Smoking is recognized as the most important hair element of the disease.

Patients with pulmonary interstitial fibrosis can exercise appropriately to enhance the body's resistance, but they should do what they can, do not exercise vigorously, they can do more abdominal pursed lip breathing, avoid colds as much as possible, and look for the cause of local fibrosis, ** underlying disease.

Introduction: What factors are involved in the development of pulmonary fibrosis?

Pulmonary fibrosis, i.e., interstitial fibrosis of the lungs. The interstitial tissues of the lungs are composed of collagen, elastin and protein sugars, and when fibroblasts are chemically or physically damaged, they secrete collagen to repair the interstitial tissues of the lungs, resulting in pulmonary fibrosis, which is the result of the body's repair after lung damage. If the lungs are compared to a sponge, oxygen can be thought of as water.

The lungs of a healthy person are like clean, high-quality sponges that absorb well. Breathing is normal at this time. If you absorb glue in a sponge, the sponge will harden as the glue solidifies.

At this point, it becomes very difficult to absorb water. Specifically, in pulmonary fibrosis, the "adhesive" is like a fibrotic substance that accumulates in the lung tissue, causing symptoms of dyspnea.

What exactly is pulmonary fibrosis all about? It could be due to the following reasons: genetics.

Investigations have shown that pulmonary fibrosis (lung) runs in families, and the onset of pulmonary fibrosis (lung) in some patients may be related to triggers. Pulmonary dysfunction. In some patients, symptoms of pulmonary fibrosis may be related to decreased lung function.

Because the decline in lung function can also damage the lung tissue, causing lesions and causing diseases. Smoking. Not only genetic, but long-term smoking also increases the risk of developing pulmonary fibrosis.

The main reason is that smoking is easy to cause damage to the lungs, and once the lung tissue is damaged, it will cause diseases and damage health. Viral infections. When the lung tissue is infected with the virus, lesions can occur, causing disease.

In addition, there are bacterial infections, chlamydia infections, parasitic infections, etc., which will increase the risk of the disease, so it is necessary to pay attention to prevention. Commonly used bottled water, in the process of loading water into the air is easy, in the season when the temperature and humidity are more suitable, spring river, spores, fungi, etc. are likely to cause rapid reproduction, at present, many water purifier filtration devices are not advanced enough, bacteria can invade the lungs through drinking water. Therefore, after drinking the bottled water within 3 to 5 days after the release, it is best to drink hot water above 90 degrees.

Pulmonary fibrosis (pulmonary) is a stubborn disease and a medical problem worldwide, and it is so far impossible to determine the specific hair element and specific drug treatment, and can only focus on controlling the disease. Pulmonary fibrosis is easy to occur in the 40-50s, and the main manifestations are dyspnea, dry cough, fatigue, acidosis, lung wetness, gas level and other pulmonary fibrosis is a stubborn disease that is difficult to develop, and dyspnea is the most common symptom of pulmonary fibrosis. As pulmonary fibrosis progresses, patients also have dyspnea when they are at rest, and patients with severe pulmonary fibrosis may experience progressive dyspnea, resulting in structural changes in normal lung tissue, loss of function, and life-threatening.

Therefore, it is important to understand the causes of pulmonary fibrosis in order to prevent it from occurring.

It may be due to exposure to some dust, irregular diet, or weakness, or exposure to some radiation, or smoking.

The body's own factors, the body's immunity is relatively low, infection with bacteria, or environmental factors, through pollution, or infection, can also occur, as well as dietary factors, unclean eating habits, causing bacteria to invade the lungs.

The causes of daily life are related, related to work and living conditions, or caused by eating some special foods, and are related to genetics, and are also related to genes.

There are genetic factors, work factors, environmental factors, long-term inhalation of large amounts of dust, fertilizers and other harmful substances, long-term smokers, etc., all of which can cause the production of pulmonary fibrosis.

It is related to diet, work and rest factors, physical factors, work factors and environmental factors. So when we confirm this situation, we must go to the hospital to do the corresponding **.

The symptoms of pulmonary fibrosis are mainly lesional tissues in the alveoli, and the main components of the alveoli are capillaries. Through the pathological examination of pulmonary fibrosis, it can be seen that the whole lung has diffuse collagen fiber hyperplasia, the alveolar wall is thickened, the elastic fiber and collagen fiber around the bronchi and capillaries are more obvious, accompanied by a large number of inflammatory cell infiltration, and there are also a large number of inflammatory cells and exudate in the alveoli, which contain a large amount of cellulose, alveolar consolidation and collapse are unevenly distributed, and some alveolar ducts are dilated. Symptoms of advanced pulmonary fibrosis, interstitial fibrosis, with emphysema.

Alveolar epithelial cells proliferate, alveolar walls thicken, and pulmonary capillaries are eroded and destroyed by fibrous tissue, and their number decreases. Intimal hyperplasia and thickening of the wall of the pulmonary arterioles. Bronchioles dilated, and cystic changes in the lungs.

These alveolar inflammation, bronchial, capillary, arteriolar pathological changes, is the process that leads to pulmonary fibrosis, so that the lung function is seriously failed, the smallest functional unit for gas exchange is the alveoli, and there are a large number of tiny blood vessels in the alveoli and related tissues, it can also be said that the main component of the alveolar wall is a single layer of vascular endothelial cells, and vascular endothelial cells are a layer of flat cells belonging to the vascular endothelium. Therefore, it is most susceptible to damage from **gens in vitro and in vivo. References:

Diagnosis and Treatment of Pulmonary Fibrosis with Integrated Traditional Chinese and Western Medicine".

Environmental factors (25%):

It is one of the important factors leading to pulmonary fibrosis disease, and the current environmental pollution is serious, especially in first-tier cities, which is full of smoke, which makes people's respiratory tract adhere to thick harmful substances, and finally stays in the lungs. Pulmonary fibrosis is common.

Smoking (20%):

According to clinical studies, smokers are at high risk of pulmonary fibrosis, and smokers are several times more likely to suffer from pulmonary fibrosis, so everyone should be cautious and stay away from cigarettes and secondhand smoke.

Physical factors (25%):

Asbestos, mineral dust, drugs, radiation damage, inhalation of harmful gases, etc. (in the case of environmental pollution, masks should be worn); Exogenous allergic alveolitis caused by exposure to pigeon droppings, animal fur, moldy and dead grass, etc., can lead to pulmonary fibrosis.

Other (15%):

Occupational, genetic, environmental, physical and chemical factors can also cause pulmonary fibrosis.

Occupational or household environmental factors: Inhalation of organic or inorganic dust can lead to hypersensitivity pneumonitis, pneumoconiosis, etc., which in turn leads to pulmonary fibrosis.

Drugs: such as amiodarone, bleomycin, methotrexate, etc.

Certain methods: radiation, high-concentration oxygen therapy.

Diseases: connective tissue diseases, vasculitis, sarcoidosis, pulmonary hemosiderosis, idiopathic non-specific interstitial pneumonia, desquamative interstitial pneumonia, etc.

Genetic factors: For example, cases of familial idiopathic pulmonary fibrosis (IPF) have been reported both domestically and internationally, and genetic factors play a role in the onset of 5% to 20% of IPF.

When lung damage is caused by a variety of causes, the interstitium secretes collagen to repair, and if it is overrepaired, i.e., fibroblasts proliferate excessively and the extracellular matrix aggregates in large numbers, pulmonary fibrosis is formed.

Pulmonary fibrosis is a major group of end-stage changes in lung diseases characterized by fibroblast proliferation and accumulation of a large number of extracellular matrix, accompanied by inflammatory damage and destruction of tissue structure, that is, normal alveolar tissue is damaged and repaired abnormally, resulting in structural abnormalities (scarring). The vast majority of patients with pulmonary fibrosis** are unknown (idiopathic), and this group of diseases is called idiopathic interstitial pneumonia (IIP), which is a large group of interstitial lung diseases. Idiopathic interstitial pneumonia (IIP) is characterized by Idiopathic Pulmonary Fibrosis (IPF), which is a severe interstitial lung disease that can lead to progressive loss of lung function.

Pulmonary fibrosis seriously affects the respiratory function of the human body, manifested by dry cough, progressive dyspnea (self-denial of qi), and the patient's respiratory function continues to deteriorate as the condition and lung damage worsen. The incidence and mortality of idiopathic pulmonary fibrosis are increasing year by year, and the average survival time after diagnosis is only one year, and the mortality rate is higher than that of most tumors, which is called a "tumor-like disease".

Dyspnea is the most common symptom of pulmonary fibrosis. In mild pulmonary fibrosis, dyspnea often occurs during strenuous activity and is often overlooked or misdiagnosed as another disorder. When pulmonary fibrosis progresses, dyspnea also occurs at rest, and patients with severe pulmonary fibrosis may have progressive dyspnea.

Other symptoms include dry cough and fatigue. Some patients have clubbing and cyanosis. Fibrosis of lung tissue is a serious consequence, resulting in structural changes in normal lung tissue and loss of function.

When a large number of fibrotic tissues without gas exchange replace the alveoli, oxygen cannot enter the bloodstream. Patients suffer from poor breathing, hypoxia, acidosis, loss of labor, and in severe cases, death.

1.The onset is insidious, and dyspnea is progressively worsening, with shortness of breath after exertion in the early stages.

2.Dry cough often occurs during deep inspiration or at the end of inspiration, and occasionally bloody sputum is seen.

3.Systemic manifestations: fatigue, weight loss, anorexia, fever in co-infection, joint pain in a few cases, chest pain is rare.

4.Patients secondary to autoimmune diseases such as lupus erythematosus, with manifestations of the disease itself.

5.On examination, thoracic breathing movements are weakened, and fine crackles or crepitations can be heard in both lungs. There are varying degrees of cyanosis and clubbing. Signs of right heart failure may be present in the late stages of Zen Wuchen. It is necessary to achieve early detection, early diagnosis**.