What is the reason why high blood pressure drugs are recommended to be taken in small doses?

In real life, a considerable number of people will suffer from the chronic disease of hypertension, since the disease until now, there is no way to be completely good, relying on long-term medication to control the condition, so that the patient can reach a normal blood pressure level, and doctors often propose to hypertension patients to take small doses of hypertension drugs, the reason is that the combination of drugs can minimize the harm of the drug and maximize the effect. <>

The reason why low-dose combination drugs are emphasized is because there are several reasons, first of all, this method will reduce the harm of drugs to a relatively small extent, and it will also have a good effect on the patient's hypertension, so if the patient is diagnosed with hypertension and needs to take antihypertensive drugs for a long time, he must use the combination of small doses. If a large dose of a single drug, although it is possible to lower blood pressure, but bring a lot, and because a single drug is taken in large quantities for a long time, it will also cause great damage to the health of the body, such as dizziness, lack of appetite, etc., in addition, because the mechanism of hypertension is very complex, the use of combined drugs can cover the onset of hypertension, which can improve our effect more efficiently, and will not make our patients' conditions reversed, unable to control hypertension well. <>

For patients with hypertension, it is best to use several drugs suitable for themselves, low-dose medication**, it is best to go to a regular hospital, so that the doctor can choose several drugs in small doses under the guidance of the doctor according to their different conditions and other concurrent cardiovascular factors, as well as different complications**. In addition, patients must strictly abide by the doctor's instructions during the medication period, and cannot use the medicine indiscriminately. It is also necessary to maintain good eating habits, not to eat spicy, greasy, raw and cold food, and to stay away from fried, puffed, and roasted food.

Different antihypertensive drugs are used in combination. It can better increase the effect of lowering blood pressure and can also reduce the adverse effects on our body.

In this way, the effect of the drug can be better, the combined use of drugs is less harmful to the body, and the speed of lowering blood pressure will be faster.

It can reasonably control blood pressure, and can also avoid drug production, which is conducive to ensuring the condition of the body and can make blood pressure more stable.

I heard from the doctor that if you take a single antihypertensive drug for a long time, you will feel that the effect will gradually weaken, and then you need to combine 2 or more antihypertensive drugs**. There are some patients with moderate and severe hypertension who also have other complications and also need to take a combination of drugs. In short**hypertension must be individualized under the guidance of a doctor, so the medication for each patient will be different If the combination of drugs often misses the dose and forgets to take the medicine, the blood pressure control is very bad, at this time, you can also choose a single tablet compound preparation with better antihypertensive effect, *** smaller, and a small number of drugs.

For example, I am now taking bisoprolol amlodipine single tablet compound preparation, it is understood that bisoprolol lowers blood pressure at the same time, can slow down the heart rate, offset the problem of increased heart rate caused by amlodipine, and provide more comprehensive protection for the cardiovascular system; Irbesartan hydrochlorothiazide tablets are also common, which can reduce the risk of hypokalemia after taking the drug. You can also ask the doctor first, and then determine the ** plan that is suitable for you under the guidance of the doctor.

Answer]: B drug ** starts with a small dose to reduce adverse reactions, if the patient has a good response to a single manuscript drug, but the blood pressure fails to reach the target, the dose of the drug should be increased if the patient can tolerate it well, and the blood pressure can be minimized by combining drugs to minimize the possible dose-related ***. If a drug has a poor response or is poorly tolerated, a different type of drug can be switched instead of increasing the dose of the first congratulatory drug or adding the second drug.

For patients with stage 2 or 3 hypertension, or those at high or very high risk of overall cardiovascular risk, the combination should be used initially**.

It can be combined with other drugs ** hypertension, and it is known as "basic antihypertensive drugs" () aFur let do Semi.

b.Hydrochlorothiazide spike servant.

c.Spironolactone.

d.Triamterene.

e.Amilori.

Correct Tan Clan Heng Answer: B

**For high blood pressure, some patients only need to take one antihypertensive drug; Some patients need to take two or more antihypertensive drugs, known as combination drugs. According to clinical studies, about 70% of hypertensive patients need a combination of drugs.

One of the most important aspects of high blood pressure is individualization. In other words, a reasonable medication regimen must be selected based on the patient's age, gender, degree of elevated blood pressure, whether there are complications, and the individual's response to the drug. Some elderly patients, on the basis of adjusting their diet, controlling their weight, quitting smoking and alcohol, and living a regular life, can achieve the expected goal of blood pressure control by taking only one drug, so there is no need to add other antihypertensive drugs!

However, many patients have a single drug effect is not ideal, and there will be many adverse reactions when increasing the dose, and even produce serious results, so that they cannot adhere to it, of course, it is necessary to consider adding another type of drug in time to achieve satisfactory efficacy. This is because drug dependence and adverse effects associated with long-term use of only one drug can be avoided by combining drugs. In addition, it can also improve the antihypertensive effect, so as to effectively prevent hypertension complicated by heart, brain, and kidney lesions.

It is very important to pay attention to the rational combination of drugs in combination drugs. For example, the combination of drug A and drug B can improve the antihypertensive effect and reduce adverse reactions, which is reasonable; If the combination of drug A and drug C is counterproductive, and the opposite antagonism is antagonistic, it will not only reduce the efficacy, but also have a certain risk, that is, it is unreasonable.

It can be seen that how to mix drugs should be selected according to the actual situation of the doctor, and the patient should not change it at will.

The effective rate of blood pressure control with monotherapy is low. Because there are many predisposing factors for hypertension, and the mechanism of its pathogenesis is also relatively complex, and most antihypertensive drugs often only work on a certain pathogenesis, and it is difficult to have the best effect on other pathogenesis.

At present, clinicians have reached a consensus on hypertension: first, hypertensive patients need to take antihypertensive drugs for a long time; The second is that high blood pressure requires a combination of two or more antihypertensive drugs. If patients can do the above two things, they can not only continue to control blood pressure, but also reduce the occurrence of cardiovascular and cerebrovascular diseases.

There are individual differences in hypertension, and I personally believe that the principle of hypertension is: if the blood pressure is lowered to the ideal range (90 140 60 90mmHg) through diet (low-salt and low-fat diet) and exercise, no drugs are used, and a good lifestyle also has a certain effect on blood pressure; If a single drug can reduce blood pressure to the ideal range within a reasonable measurement range, a single drug is used**; If a single drug** needs to be increased or the effect is not ideal, it is necessary to combine drugs, which can effectively lower blood pressure, reduce the dose of drugs, and reduce the drug at the same time. Monitoring blood pressure is the basis for guiding medication.

Keeping your blood pressure within the ideal range at the lowest cost is the best way to do it.

(1) The principle of individualization: that is, the medication varies from person to person. The choice of drug for each patient should be based on:

The blood pressure level of each person, the degree of elevation and the urgency and slowness, whether the patient has cardiovascular risk factors, whether there is target organ damage, whether there are clinical cardiovascular diseases, kidney diseases, diabetes mellitus and other comorbidities, pay attention to the interaction of combined drugs, avoid the use of drugs that affect the antihypertensive effect, how much evidence is there that drugs reduce cardiovascular risk, and the patient's long-term economic affordability. (2) Monotherapy initiation. (3) When choosing any kind of drug to start with, the lowest dose should be used to reduce the toxicity.

4) Increase the dose of the drug as appropriate according to the efficacy of the drug and the patient's tolerance. (5) If the first drug is ineffective and the blood pressure fails to reach the target, the combination drug is better than a high-dose single drug**, so a small dose of the second antihypertensive drug is usually added, rather than an increase in the dose of the first drug. The combination of drugs can achieve the maximum antihypertensive effect and the least incidence of adverse reactions.

Effective combination combinations are: diuretic receptor blockers, diuretic ACE inhibitors (or angiotensin receptor antagonists), calcium ion antagonists (dihydropyridine) receptor blockers, calcium ion antagonists ACE inhibitors, adrenergic receptor blockers Receptor blockers. (6) If the first drug is poorly tolerated, another class of antihypertensive drugs can be changed, instead of increasing the dose of the first drug or adding the second drug.

7) Try to choose a long-acting drug that can be taken once a day and has a 24-hour stable antihypertensive effect. It is characterized by improving the compliance of patients, controlling blood pressure more smoothly, protecting target organs, and reducing the risk of cardiovascular disease events.

One of the hallmarks of antihypertensive drugs that can last 24 hours is the antihypertensive trough-to-peak ratio of 50%, that is, the maximum antihypertensive effect of more than 50% after 24 hours of administration. (8) Gradually lower blood pressure. (9) When ** is ineffective, the drug should be used to reach a sufficient dose before deciding on the choice of a class of drugs.

10) Do not stop the drug abruptly or stop a drug abruptly. (11) Proficiency in and persistence in the use of drugs, new drugs may not be the best. (12) Try to choose drugs that do not affect mood and thinking.

13) Long-term**.