Does the design and research of two faced god adhesion hydrogel be of great help to medicine?

The two-sided god adhesion hydrogel designed by the team of Professor Liu Wenguang of Tianjin University shows a magical two-sided effect. This achievement, published in Advanced Functional Materials, has attracted a lot of attention. To put it simply, the two sides of this gel are reflected in:

One side is adhesive, while the other side is completely non-adhesive, and the material itself is degradable and does not cause any pollution.

In fact, if you take a cursory look, everyone will think that this two-sided tape is used in which field? The double-sided tape we encounter in our lives is actually adhesive on both sides, and it is mainly used to fix some lightweight materials and objects. And the purpose of this hydrogel is obviously not so simple.

This amazing two-faced god adhesion hydrogel is mainly used in medicine, especially for in vivo sutures during surgery. In daily life, we will meet older family members or friends who need surgery due to some diseases, and it is inevitable that there will be trauma and sutures during the operation, although the operation is successful, but when the wound is sutured, it is inevitable that there will be adhesions between the tissues in the body, and the adhesions of the tissues in the body will not get better after the body gradually scabs over and recovers. It is inevitable that it will be affected in daily life.

The special two-sided nature of this gel may be widely used in future surgeries.

One side of the hydrogel adheres perfectly and firmly to the wound, almost replacing sutures during surgery, while the other side is non-adhesive and avoids tissue adhesion. This result may effectively avoid the adhesion of sutures to the tissues in the body that are often encountered in conventional surgical operations in the future, and avoid the possible organ damage in severe cases. The degradability of this hydrogel is also worth promoting in a medical context.

Of course, whether it can be a perfect replacement for surgical sutures needs to be further confirmed.

This hydrogel is a one-sided immersion of the hydrogel containing carboxyl groups in the side chain by using oligosaccharides, and the oligosaccharides are gradient recombined with the carboxyl groups inside the gel, thus forming a two-sided hydrogel that can quickly adhere to tissues under the state of affairs.

It is definitely of great help to medicine, because its material is suitable for medical surgery, and it has good performance in bonding wounds, so people can use it to shorten the time and reduce the pain of stitches and stitches during surgery in the future.

Every study has its meaning, whether it is successful or unsuccessful, it is a kind of reminder, and the two-faced god saves the time of suturing the operation and eliminates the need to remove the sutures.

The design and research of "two-faced god" adhesive hydrogel is of great significance to medicine, which can reduce surgical suture, secondary trauma to patients, alleviate patients' pain, prevent organ adhesion, and promote organ repair.

Of course, it has a great contribution, because this adhesive hydrogel brings great convenience to doctors' surgery, and it also has a very large role in the recovery of patients' wounds, which is a very good design research.

If this glue is designed, it can save the time of suturing the operation and avoid the pain of removing the sutures in the future.

Liu Wenguang, a professor at Tianjin University, designed a two-sided god adhesion hydrogel, which has very strong adhesion. One side can be firmly adhered to the wound and can be sutured directly instead of surgical threads. On the other hand, the adhesive is non-adhesive and prevents tissue from re-attaching, and the adhesive can be broken down in 14 days in the body, and the results were published on September 11.

This adhesive does not play a big role in the repair of internal organs, but it is of great significance. It is well known that during major surgery, doctors will suture the tissues and organs in the body, but the use of surgical sutures may cause secondary damage to the tissues and cause aggravated pain for the patient. It may also cause tissue adhesions, and although suturing is simple and easy to perform, it is important to find suitable biodegradable tissue to replace surgical sutures.

However, the existing adhesive is double-sided, which means that it also adheres to other tissues on the outside. It can cause tissue adhesion and also affect the wound repair of visceral tissue. The hydrogel designed by Liu Wenguang uses oligosaccharides to carry out a single-sided reaction on the side chain carboxyl-containing hydrogel, resulting in the reaction of the oligosaccharides and the carboxyl group of the gel, thus forming a single-sided hydrogel that cannot adhere to the tissue.

The side of this hydrogel that is in direct contact with the oligosaccharide loses its adhesion, while the side away from the oligosaccharide retains adhesion. Therefore, the other side shows excellent adhesion to biological soft tissues, and now this two-sided hydrogel has also been repaired with animal gastric perforation. This invention is really amazing.

It will be very suitable for organ repair, such as gastric ulcer perforation, and even surgical trauma.

It is important to know that human trauma is divided into two categories, one is complete trauma and the other is incomplete trauma. The difference between the two is huge. This two-sided hydrogel will make the wound heal more easily and will not even have adverse effects.

The use of this hydrogel for wound healing can prevent infection.

The principle is to use the relevant principle of carboxyl group, with a hydrogel containing carboxyl group for single-sided soaking, and then the oligosaccharide and the internal compound of the gel, and finally in the wet state can quickly bond the organ.

The side of the carboxyl-containing gel in direct contact with the oligosaccharide loses its adhesion because the carboxyl group is almost completely compounded; The side away from the oligosaccharide solution is adhesive because the free carboxyl group is retained on the outermost surface, and the phase separation caused by the electrostatic recombination of carboxyl and amino groups also gives the surface the ability to hydrophobic and drain water, so this side surface shows excellent wet adhesion effect to biological soft tissues.

The advantages of this new technology are very prominent, first of all, it has good adhesion on one side, and no adhesion on the other side, which can be replacedSurgical suturesSecondly, it does not have to worry about tissue adhesion after surgery, and there is no need to remove surgical threads.

There are currently two traditional surgical methods, one is to suture the wound site with surgical threads. However, this method is easy to cause secondary damage to the patient's wound, and many of the current surgical threads still need to be removed after surgery, and the patient will still feel pain when the sutures are removed.

The second method is to adhere to the patient's wound with a biodegradable adhesive. The advantage of this method is that it is used directly, it will not cause damage to the patient's wound, and it does not require a subsequent suture removal process, and the disadvantages are also obvious, the adhesion effect on both sides of the adhesive has an adhesion effect, on the one hand, the patient's wound adheres to healing, and on the other hand, it will adhere to the patient's normal tissue.

So now there is an urgent need for a new type of material, and Tianjin University.

Professor Wenguang Liu recently had some clue about this material, and he led his research team to design a new type of adhesive hydrogel named "Two-Faced God".

The properties of this new material are exactly what you need. One side has strong adhesion to tissues, which allows the wound to be better attached to the wound and facilitate healing, while the other side shows a diametrically opposite effect, so that there is no worry about tissue adhesion and hindering repair.

Therefore, if the two-faced god adhesion hydrogel can be realized and mass-produced, it will greatly improve the convenience of surgery, and it will only be beneficial to the wound healing of patients, and there are many benefits. Because in today's clinical investigations, postoperative recovery is a major problem, and many patients have different recovery conditions due to different individual constitutions and different environments.

Many patients have complications from surgery after surgery.

In addition to bleeding, inflammation, and infection, which are relatively common postoperative complications, there is also a large category of postoperative tissue adhesionsIf this hydrogel can be widely used in clinical practice in the future, this undesirable condition will be greatly improved.

Compared with traditional surgery, the characteristics of Two-Faced God Adhesion Hydrogel are more convenient, more advanced, and more optimized. Because he still has many advantages over traditional surgery.

This glue allows for faster repairs of organs without leaving any traces than traditional surgery.

In fact, the "two-faced god" adhesion hydrogel does not play a major role in the repair of internal organs, because whether it is the repair of internal organs or the recovery of wounds on the surface of the body, the main role is the repair function of our body.

Trauma recovery in our human body is mainly divided into two main categoriesOne is complete trauma recovery, which means that after the wound is recovered, it is still in its original form and function, and the other is incomplete trauma recovery, which refers to trauma recovery that does not have the original function and form after recovery.

The difference between the two is like building a house, when the wall is built, there should be bricks as a support, there is mud and sand filling, and finally the wall paint is painted, complete trauma repair is that the wall is broken, after repair, there are still bricks, sediment, and the function is intact, but incomplete trauma repair, just like the wall is broken, blocked with sand and gravel, and finally sealed casually, so it looks like it is still the same as before, but in fact, this part can no longer shelter from the wind and rain.

It can be seen that our existing medical methods are basically only to promote trauma recovery, and the "two-faced god" "adhesion hydrogel is like a surgical suture, so that the fractured surface of the wound is attached together, so that the wound is easier to heal,With the same function, there are various adverse effects that will be caused by the absence of surgical sutures, such as the need to destroy the tissues near the wound after surgical sutures, and the removal of the surgical threads that have not been absorbed after the wound has healed to prevent infection.

Secondly, the "two-sided god" adhesion hydrogel has single-sided adhesion, unlike other adhesion gels, after the wound fracture surface is pasted together, the other side often inadvertently adheres to the normal tissue, causing organ adhesionOne side is used to adhere to damaged tissues, protect wounds and promote healing, and the other side does not adhere to other tissues due to its special molecular structure.

And according to the research of Professor Liu of Tianjin University, the gel can be degraded in 14 days by the human body, which is non-toxic and harmless, and will not cause any adverse effects on the wound. It is ideal for organ repair such as gastrointestinal ulcers, perforations, surgical trauma, and other organ trauma repair.

Its principle is the same as glue, the visceral wound is glued to promote the body's own wound repair, and the other side is not sticky, will not produce adhesion to other organs, and can also be absorbed within 14 days, this is really a revolution in medicine, the gospel of people who need to operate on the abdomen.