Nifedipine extended release tablets the difference between Degonine and Naxintong?

The mechanism of action and indications of the two drugs are the same, but the content specification of nifedipine sustained-release tablets (Naxintong) is 20mg20 tablets, while nifedipine sustained-release tablets (Degaoning) 10mg50 tablets, generally speaking, there are types of such drugs, the first two are not much different, and the third action time will be longer. Look

Due to the strong medicinal properties, some patients will have some uncomfortable symptoms after taking them. So, what are the degaoning nifedipine sustained-release tablets***?

Degonine nifedipine extended-release tablets can delay sinus node function and atrioventricular conduction in isolated heart; Electrophysiological studies of whole animals and humans have not found that Shengtongping nifedipine sustained-release tablets have the effect of delaying atrioventricular conduction, prolonging the recovery time of the sinus node and slowing down the rate of the sinus node.

Degonine nifedipine extended-release tablets***:

1.Liver: Occasionally, jaundice and elevated glutamic acidacetate aminotransferase and glutamic acid acetonate aminotransferase.

2.Circulatory system: Due to the rapid dilation of blood vessels with nifedipine, chest pain, headache, flushing, dizziness, palpitations, blood pressure drop, and edema of the lower limbs occasionally occur.

3.Allergies: Occasional allergic symptoms such as measles and itching.

4.Digestive system: Occasional abdominal pain, nausea, loss of appetite, constipation, etc.

5.Oral: Gums may be hypertrophied.

6.Metabolic abnormalities: Occasional symptoms of hyperglycemia.

Pharmacological effects of Degaoning nifedipine sustained-release tablets: Nifedipine sustained-release tablets can simultaneously relax the coronary arteries in the normal blood supply area and ischemic area, antagonize spontaneous or ergometrine-induced coronary artery spasm, increase the delivery of myocardial oxygen in patients with coronary artery spasm, and relieve and prevent coronary artery spasm. It can also inhibit myocardial contraction, reduce myocardial metabolism, and reduce myocardial oxygen consumption.

Nifedipine sustained-release tablets have good efficacy and fast onset, consumers should use the drug according to the instructions when using it, and the correct medication is the premise of guaranteeing the best of the best.

The gastrointestinal absorption of Naxin and nifedipine sustained-release tablets is rapid and complete, and the bioavailability of nifedipine is low due to the first-pass effect of the liver, and the peak blood concentration of nifedipine sustained-release tablets is between hours, and the blood concentration time curve is smooth and long-lasting, and the minimum effective blood concentration (10ng ml) can be maintained for more than 12 hours after each dose.

Nifedipine is widely distributed in tissues, and the concentration of the drug is higher in the liver, serum, kidneys and lungs, but lower in the brain and skeletal muscle. The plasma protein binding rate of nifedipine in human body is higher than 92%-98%, but the protein binding rate of its main metabolites is low, which is 54%, and nifedipine acts in vivo through the liver microsomal enzyme system (including cytochrome P450 monooxidase).

The dosage of Naxin and nifedipine sustained-release tablets is:

1.Swallow whole on an empty stomach without chewing or breaking.

2.Start with small doses. The initial dose is 20 mg times and the maximum dose is 60 mg times a day. The maximum daily dose should not exceed 120 mg.

3.The dose of nifedipine should be titrated according to the patient's tolerance and control of angina. The patient's blood pressure should be monitored before increasing the dose. If the patient's symptoms are obvious, the dose adjustment period can be shortened according to the patient's response to the drug.

4.No rebound symptoms were observed at the time of discontinuation of the drug, but the dose should still be tapered and the patient should be closely observed.