What is systemic lupus erythematosus?

Hello: Systemic lupus erythematosus (SLE), abbreviated as "lupus erythematosus" or "lupus", is a very common autoimmune disease, which is more common in women during the reproductive period, has a strong genetic background, and is prone to develop diseases under the triggers of elevated female hormones (such as pregnancy), ultraviolet radiation, chemical pollution, infection, etc. In addition to various symptoms such as fever, facial erythema, arthralgia, anemia, and pleurisy, lupus patients can also affect the heart, kidneys, lungs, central nervous system, and other organs.

Common complications of systemic lupus erythematosus: clinical statistics show that lupus pneumonia accounts for about 10% of complications in lupus patients, lupus nervous system damage accounts for 20%, lupus heart damage accounts for about 30%, and lupus kidney damage accounts for about 50%. More than 90% of people with systemic lupus erythematosus eventually develop kidney damage.

Patients with lupus renal impairment should have the following laboratory tests before and during follow-up: Routine blood tests to check for anemia, leukopenia or thrombocytopenia; Urine tests.

including urinalysis, sediment microscopy, proximal and distal tubular function tests; liver function and kidney function tests; Autoantibody; Complement; cryoglobulins; CD4+ CD8+ T lymphocytes; ESR, CRP, etc.

Urine tests are very important. Not only can it be determined whether the kidneys are affected, but also whether lupus nephritis is active. Urine tests usually include 24-hour urine protein quantification, urine sediment microscopy, urine white blood cell count with differential, urine N-acetyl--D glucosaminidase (NAGase), urine retinol-binding protein (RBP), urine osmolality, urine C3 2-mg uric acidification, etc.

The purpose of this study is to understand the degree and activity of glomerular and tubular injury, which is an important indicator for judging the condition, choosing the best plan, and judging the prognosis.

Systemic lupus erythematosus is a refractory disease and a chronic disease, which cannot be completely **, but it is by no means an "incurable disease". A lot of misinformation and mispropagation among the people have brought a lot of negative effects to patients. Therefore, when some patients hear that they have "systemic lupus erythematosus", it is as if the sky is falling, and they lose control of their emotions and think that life and life have lost their meaning.

In fact, since the 50s of the 20th century, the application of glucocorticoids and immunosuppressants has greatly improved the rate of systemic lupus erythematosus, the overall clinical effective rate is as high as more than 80%, and the long-term renal survival rate has also increased significantly. Therefore, we believe that lupus can be treated with **, and that the disease can be controlled and stabilized to work and live as a normal person. We encourage patients to go to a regular medical unit, be active, take their medications on time, and follow up regularly.

Avoid trusting traveling doctors and abusing home remedies and secret recipes.

Systemic lupus erythematosus is a systemic autoimmune disease in which patients can have a variety of autoantibodies in their serum, and there is obvious immune dysfunction. The patients are more common in young women, and the ratio of males to females is 1 7 10, and the prevalence rate in China is higher than that in Western countries.

The clinical manifestations of systemic lupus erythematosus (SLE) have no fixed pattern, prolonged over time, and the remission period varies from person to person, and can be explosive, acute or insidious at the onset, and can be affected by a single organ or multiple organs at the same time, and the disease is milder in elderly patients. Systemic symptoms include fatigue, fever, and weight loss, and there are a variety of predisposing factors, including sun exposure, pregnancy, childbirth, medications, and surgery.

Patients with this disease should avoid sun exposure and ultraviolet rays. Patients with heavy internal heat should eat cold food, and beef and mutton may induce and aggravate the condition. Fruits should be raw pears, watermelons, raw lotus roots, etc.

Lupus erythematosus (LE) is a classic autoimmune connective tissue disease that is more common in women aged 15 to 40 years. Lupus erythematosus is a disease spectrum disease, which can be divided into discoid lupus erythematosus (DLE), subacute ** lupus erythematosus (SCLE), systemic lupus erythematosus (SLE), deep lupus erythematosus (LEP), neonatal lupus erythematosus (NLE), drug-induced lupus erythematosus (DIL) and other subtypes.

The disease of lupus erythematosus is completely controllable, traditional Chinese medicine can receive miraculous effects under the clear differentiation of syndromes, and there are people around who rely on Chinese medicine ** Now they live normally, and they can provide a month of Chinese medicine for free to try the curative effect, I wish you an early **!

Sometimes when there are some spots or erythema on our body, we may not pay much attention to it, there may be some erythema due to allergies or relatively simple problems, but some may be systemic lupus erythematosus, many people may not be very clear about this, so let's talk about his symptoms.

1. Systemic lupus erythematosus.

In fact, systemic lupus erythematosus is a kind of autoimmune inflammation and connective tissue disease that occurs more often in young women, multiple organs, and connective tissue disease, generally in the early stage with mild or atypical cases, in fact, the main reason for this situation is because of genetic or endocrine system and infection immune abnormalities, or the relationship between general environmental factors and the disease is very large, according to genetic factors, environmental factors and estrogen levels, various factors interact, it will lead to T lymphopenia, The first throwing line eight functions to reduce the excessive proliferation of B cells to produce a large number of autoantibodies, and correspond to them in vivo. Autoantigens bind to form corresponding immune complexes.

Fever, fatigue, weight loss, arthritis, and more commonly early manifestations include skin lesions, polyserositis, renal lesions, central nervous system damage, blood abnormalities, and gastrointestinal symptoms.

1. Systemic symptoms: fever, fatigue, weight loss, etc. 2. Facial erythema and various rashes, allergies after sun exposure.

3. Hair loss. 4. Repeated mouth ulcers. 5. Arthralgia, myalgia, muscle weakness, and extremities turn from white to purple and then red when cold.

6. Chest tightness, shortness of breath, dry cough. 7. Mental disorders, seizures, hemiplegia, etc. 8. Loss of appetite, vomiting, bloating, etc.

9. Epistaxis, bleeding gums, purpura, etc. 10. Swollen lymph nodes.

**and mucosa: the typical manifestations of **and mucosa are erythema with butterfly-shaped distribution on the bridge of the nose and cheeks, and other ** lesions include sun sensitivity, alopecia, palmar and periungual erythema, discoid erythema, erythema nodosum, panniculitis, erythema reticularis, Raynaud's phenomenon, etc.;

Lupus erythematosus is an autoimmune disease with a slow onset, insidious occurrence, and diverse and varied clinical manifestationsAn autoimmune disease involving many systems and organs, due to cellular and humoral immune dysfunction, a variety of autoantibodies are produced, so, what are the symptoms of systemic lupus erythematosus? Let's take a closer look at the following experts. The symptoms of systemic lupus erythematosus are varied:

1. Photoallergy: The patient has a rash on the face or exposed part of the skin after being exposed to sunlight or ultraviolet rays. It is a red macules, papules, or patchy rash.

with burning, itching, or stinging. Sometimes erythema multiforme, urticaria, discoid erythema, or bullous rash. 2. Bullous lupus erythematosus:

Blister-like lesions (rare). 3. Alopecia discoid erythema: the periphery of the rash is slightly higher than the center, the peripheral pigment is deepened, the central pigment disappears, the capillaries are dilated, and the old lesions have ** atrophy.

4. Mucosal ulcers: the mucosa of the oral cavity, hard palate, buccal mucosa and lip are the most susceptible to involvement. 5. Arthralgia:

It is common in the interphalangeal joints, wrists, and knee joints. This is followed by ankles, elbows, shoulders, and hips, which are swollen and painful, and sometimes have effusion. Bone damage is uncommon.

6. Myalgia: 70% of patients with systemic lupus erythematosus have myalgia, muscle weakness and muscle tenderness. 7. Pleural lesions:

Pleural inflammation presents with chest pain, fever, dyspnea, pleural effusion. 8. Lupus pneumonia: the patient has fever, cough, and rales in the lungs.

Lupus nephritis: patients have proteinuria, microscopic hematuria, leukocytouria, casts of urine, edema, hypertension, or renal insufficiency.

Systemic lupus erythematosus is a specific autoimmune disease involving multiple factors (including genetics, sex hormones, environment, infection, drugs, and immune response). The disease is more common in women, accounting for about 90%, often women of childbearing age, about 25% of patients have kidney as the first manifestation, of which 5% of patients with renal disease persist for several years before systemic manifestations. The main symptoms include the following.

In the early stages, most patients have no obvious symptoms, and some patients may present with fever, tiredness, fatigue, and weight loss. Patients in the acute phase may present with fever, muscle pain, arthralgia, hair loss, mouth ulcers, etc., and patients with heart involvement may have palpitations, shortness of breath, and discomfort in the precordial area. Patients with renal involvement may have eyelid puffiness or edema of both lower extremities; Relevant data show that 10% of patients with lupus erythematosus can affect the central nervous system, and neurological symptoms such as agitation, hallucinations, delusions, and suspicion occur; About 15% of patients have seizures; If the disease affects the digestive system, symptoms such as loss of appetite, abdominal pain, nausea and vomiting may occur.

Only by doing an examination can you find it accurately.

At the mention of lupus erythematosus, many people immediately change their faces and are terrified. In fact, lupus erythematosus is not as serious as most people think, and patients can not only continue to work, but also get married and have children, the problem is to detect it early. If the disease can be detected at an early stage, the lesion will often only invade ** and do not damage the internal organs, or even if the internal organs are damaged, it is relatively mild and easy to control and recover.

At present, as an individual or family, in order to detect lupus erythematosus early, it is necessary to grasp the following symptom characteristics:

1. There is butterfly erythema on the face.

2. Discoid erythema.

3. Light allergy.

4. Arthritis but not accompanied by deformity.

5. Canker sores.

6. Pleurisy or pericarditis.

7. Epilepsy or psychiatric symptoms.

If you can find 3 or more of the above symptoms, you can suspect that you have the disease. Specifically, if the patient has ** lesions such as butterfly erythema, it will be easier to diagnose early, but about 10% 20% of patients can have no ** damage at all, which is easy to be mistaken for other diseases, such as chronic nephritis, rheumatism, blood diseases, etc. Therefore, the possibility of lupus erythematosus should be considered in patients with long-term fever that does not go away and the cause is unknown, especially if there is a combination of multiple organ damage or long-term blood abnormalities such as leukopenia, thrombocytopenia, hemolytic anemia, etc.

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According to daily life, it can be found that there is a constant fever, and there may be a large amount of hair loss for a long time, and there is a lot of damage to the internal organs, but it is necessary to go to the hospital for a blood test.

Butterfly erythema on the face, swelling of the prometacarpal joint, early morning stiffness of the feet, fatigue, severe hair loss, and fever may be present in the early stage.

This disease affects many systems of the body, mucous membranes, internal organs, etc., and the main symptoms are facial erythema, erythema, alopecia, joint pain, fever, kidney lesions, pleurisy, etc.

The symptoms of systemic lupus erythematosus can be manifested in various aspects, especially in the middle and late stages of the disease, patients must be aware of their symptoms, and if they find that there are particularly serious symptoms or sudden symptoms, they should contact the doctor in time for their own diagnosis and **.

What causes systemic lupus erythematosus? The cause of systemic lupus erythematosus remains unclear to this day. Numerous studies have shown that genetic, endocrine, infectious, immunological, and environmental factors are associated with the pathogenesis of lupus erythematosus.

Genetic factors have been found in epidemiological investigations, and some alleles of HLA are associated with the occurrence of lupus, and complement gene defects are significantly increased in lupus patients. In addition, the abnormal formation of apoptosis information of some apoptosis genesis genesis leads to tolerance or inactivation, and loses its effect in the body, resulting in the prolongation of the lifespan of activated TB lymphocytes, a significant increase in the number, and the production of a large number of autoantibodies. In addition, among environmental factors, such as ultraviolet radiation, drug application and viral infection, which are infectious factors, including Epstein-Barr virus, herpes virus, etc., are also related to the pathogenesis of lupus erythematosus, and estrogen levels also play an important role in the pathogenesis of lupus.

In addition, the combined effect of the above factors induces autoimmune diseases, and various autoantibodies and corresponding antigens form soluble immune complexes, which are deposited in target organs, such as kidneys, etc., with the participation of complement, causing inflammatory reactions in blood vessels and corresponding tissues and organs throughout the body, causing damage to lupus erythematosus.

Systemic lupus erythematosus is a chronic autoimmune disease with multiple system impairments, usually starting in the twenties to forties.

An autoimmune disease characterized by increased antinuclear antibodies in the blood, the cause of which is unknown. But it is related to genetics, environmental factors, estrogen, etc.

Environmental factors mainly include sunlight, ultraviolet rays, drugs or some biochemical agents, which may cause the occurrence of this disease. At the same time, systemic lupus erythematosus is more common in women, so it may also be related to estrogen.