What does Down s screening check? What does the Down Syndrome Screening look for?

Children with Down syndrome have severe intellectual disability, are unable to take care of themselves, and are accompanied by complex cardiovascular diseases, which require long-term care from their families, which will cause great mental and financial burden to their families.

Screening for Down syndrome usually refers to the detection of high-risk pregnant women who are pregnant with birth defects through the detection of maternal serum markers. Down syndrome is an episodic condition, so every pregnant woman has the potential to have a "Down syndrome". The chance of having a baby with Down syndrome increases with the age of the pregnant woman.

Down's screening needs to be carried out on an empty stomach, and the serum of pregnant women is taken to detect the indicators of pregnancy-related plasma protein A (PAPP-A), free HCGB subunits (early two items) or alpha-fetal protein (AFP) and chorionic gonadotropin (HCG) and free estriol (UE3) (three items in the middle stage) in the maternal serum, combined with the expected date of delivery, weight, age and gestational age at the time of blood collection, to calculate the risk factor of "Down syndrome", so that 80% of Down's children can be detected.

How is it screened? During the Down syndrome screening, you should not eat or drink after 12 p.m. the night before the test, and come to the hospital the next morning on an empty stomach for the test. In addition, the examination is also related to the menstrual cycle, weight, height, exact gestational age, gestational age, and it is best to consult your doctor about other preparations before the examination.

Screening includes the sampling of pregnant women's serum, the detection of pregnancy-associated plasma protein A (PAPP-A), free HCGB subunits (two early years) or alpha-fetal protein (AFP) and chorionic gonadotropin (HCG) and free estriol (UE3) in maternal serum, combined with the expected date of delivery, weight, age and gestational age at the time of blood collection, to calculate the risk factor of "Down syndrome", which can detect 80% of Down's syndrome children.

The clarity of the neck, the length of the nasal bone, femur and humerus, ventricular bright spots, cardiovascular deformities, etc. are mainly checked.

Down Syndrome Screening is the abbreviation of Prenatal Screening Test for Down Syndrome, which is a special examination method. The purpose is to test the blood of pregnant women, detect the concentration of alpha-fetal protein, chorionic gonadotropin and free estriol in maternal serum, and judge the risk factor of fetal congenital stupidity and neural tube defects in combination with the age, weight, gestational age and other aspects of pregnant women.

First of all, it is recommended that you must understand that Down's child itself is a child with chromosomal abnormalities and a series of diseases, and the most common thing in general is that there is an extra chromosome 21 in the human body, so Down's child's self-care ability is basically zero. In this case, it means that the baby does not cry or make trouble, and any eating, drinking, and Lazar needs to be cared for, and the impact on the family is very heavy. In the screening process of Down syndrome, it can help pregnant women to know whether their child has Down's syndrome as soon as possible, and if they know it as soon as possible, they can solve it as soon as possible.

In general, the screening method for children with Down syndrome is mainly based on the Down's screening method, which is very simple to draw blood for testing. Thankfully, this test is very low-cost, risk-free, and has a wide range of applications in hospitals, but it is only about 60% accurate, so it has been mixed. There is also a method of DNA screening, which has a high accuracy rate of more than 98%, which shows that it is much higher than the Down's screening method alone.

The test method is also based on blood testing, but the fee may be higher, but there is no risk, and the main test is to check whether chromosome 21 in the fetus chromosome is normal.

What is the screening method for Down's syndrome? There is also an amniocentesis test, which is the method that is chosen after the above two methods have been examined and the results are found to be abnormal. And it must be required for women to be carried out after 20 weeks of pregnancy, the cost is relatively high, but amniotic fluid can be extracted, and the chromosomes can be fully examined, and the accuracy rate is as high as 100%.

However, it is important to note that there may be a slight risk in this case, but there is no harm to the baby.

1.Down's screening is the abbreviation of prenatal screening examination for Down syndrome, and is one of the must-do items for prenatal examination, which is a detection method that selects high-risk pregnant women with fetal aneuploidy 21-trisomy and trisomy 18 by sampling the serum of pregnant women and detecting the level of certain biochemical indicators in the maternal serum, and calculates the risk factor of giving birth to a Down syndrome.

2.Down syndrome is a chromosomal defect with an extra strip on chromosome 21, so it is also called trisomy 21. The main manifestations are severe intellectual disability, strange face, low ear position, wide eye distance, thick neck, and limb deformities.

Because children with Down syndrome have severe intellectual disability, congenital stupidity, and dementia with protruding tongue, they are completely unable to take care of themselves and are accompanied by complex cardiovascular diseases, and they are unable to ** for life. In China, for example, a Down's child is born every 20 minutes, which can be a heavy mental and financial burden for families.

3.Down serologic screening is an effective way to check for Down syndrome, and any pregnant woman can conceive a fetus with Down syndrome. In the past, it was believed that those over 35 years old were at high risk, and the chance of having a child with Down syndrome increased with the age of the pregnant woman.

It is now thought that 80% of cases of Down syndrome occur in pregnant women younger than 35 years of age.

4.Down's screening can narrow down the scope of amniotic fluid testing without missing pregnant women who may be pregnant with Down's baby, so it is recommended that every pregnant woman undergo Down's screening to prevent it from happening. Serum AFP and HGG can also screen for high-risk pregnant women with neural tube defects, trisomy 18 and trisomy 13.

Down's screening is mainly to check whether there are congenital genetic abnormalities such as trisomy 21, and if there is, it is not recommended to be born.

Down's screening is to see if there is a probability and risk of developing Down syndrome.

Down's screening is to test the blood of pregnant women, detect the concentration of alpha-fetal protein, chorionic gonadotropin and free estriol in maternal serum, and combine the age, weight, gestational age and other aspects of the pregnant woman to determine the risk factor of fetal congenital stupidity and neural tube defects. The optimal testing time is generally 15-20 weeks.

1. Pregnant women will be tested for serum in the Down syndrome screening, and whether the fetus has neural tube defect symptoms and trisomy syndrome can be determined. Pregnant women can go to the same hospital for blood screening one week before the prenatal examination, and wait until the prenatal examination time to get the results, once the screening is seropositive, the biopsy chorion and puncture amniotic fluid examination should be done to confirm the diagnosis.

2. Pregnant women should ensure sufficient rest the day before the Tang screening, do not drink water and eat from 12 o'clock at night until the end of the examination, and keep an empty stomach after getting up in the morning. During the examination, the doctor will ask the pregnant woman some relevant questions, and the pregnant woman's answers must be accurate.

3. In the screening of Down syndrome, the doctor will judge the probability of the fetus suffering from "Down syndrome" based on the various indicators detected and the pregnant woman's own situation, and the accuracy of this result is very high.

1. Down's screening is a kind of ante belt to detect the concentration of type A fetal protein, chorionic gonadotropin and free estriol in maternal serum by sampling the serum of pregnant women, and combined with the expected date of delivery, weight, age and gestational age of pregnant women at the time of blood collection, etc., to determine the risk factor of fetal congenital stupidity and neural tube defects.

2 Any pregnant woman can conceive a fetus with Down syndrome. Children with Down syndrome have severe intellectual disability, congenital stupidity, dementia with protruding tongue, complete inability to take care of themselves, and complex cardiovascular diseases, which will bring heavy mental and economic burden to the family. It is recommended that every pregnant woman be screened for Down syndrome.

If the fetus is eventually diagnosed with these congenital conditions, the pregnant woman can make her own decision about whether to continue the pregnancy.

3. This examination is mainly in the 10th, 13+6th week of pregnancy, and the two screening methods of "ultrasound" and "blood drawing" are used. Through ultrasound, the thickness of the nuchal translucency of the fetus can be clearly measured, and the risk of Down syndrome can be estimated by blood tests to measure the plasma protein A value and chorionic gonadotropin in the maternal serum.

At the 15th and 20th week of the mother's blood, the hospital will measure the serum levels of alpha-fetal protein, chorionic gonadotropin, free estriol and inhibin, and calculate the risk of Down syndrome in the fetus according to the mother's age, number of weeks of pregnancy and weight.

It is important to discuss this test with your doctor before you want to do it, as it is an invasive test that requires you to take a sample of cells from the developing placenta. For example, when a pregnant mother undergoes screening during the first trimester, if the nuchal translucency of the fetus exceeds 3 mm, chorionic sampling can be considered for chromosome examination. However, the results will not be known until 14 days later.

This is also an invasive test, but it is less risky than chorionic sampling. Dr. Huang Xuguang said that by taking the amniotic fluid from the amniotic cavity in the uterus of the pregnant mother for testing, we can know whether the chromosomes of the fetus are abnormal, and then know whether there is a possibility of Down syndrome. It takes 14 days to get the results, and the accuracy rate is more than 99%.

Down's screening mainly uses laboratory tests of the pregnant woman's blood, combined with other clinical information, to comprehensively determine the risk of the fetus with Down syndrome, if the results of the Down screening test show that the risk of the fetus has Down syndrome is relatively high, further confirmatory tests should be carried out - amniocentesis or chorionic villus examination.

4. Preparation before the examination: There is no need to have an empty stomach when doing Down's screening, and it is enough to draw the peripheral blood of pregnant women, but Down's screening is related to menstrual cycle, weight, height, accurate gestational age, and gestational age, so it is best to consult the doctor about other preparations before the examination.

Down's screening refers to the screening of Down's syndrome (congenital stupidity, tongue-sticking dementia), which is to draw chorionic blood or amniotic fluid for cell culture, and then do karyotype analysis, such as the 21-triparrow syndrome map, the fetus can be diagnosed as Down's comprehensive middle-aged orange sign.