What are the causes of high uric acid and what are the causes of high uric acid

In recent years, we have paid more and more attention to the problem of uric acid, which is known as the fourth highest, which can induce the appearance of gout. We have uric acid in our body, and we will produce and metabolize uric acid every day, so our body is in a state of balance.

**In case of high uric acid, you can eat more daylily.

In terms of the amount of uric acid produced and excreted in the body every day, one-third is produced by food, two-thirds is synthesized by the body, one-third is excreted from the intestines, and two-thirds is excreted from the kidneys. Problems in any of these pathways can lead to an increase in uric acid.

Uric acid rises because it blocks the process of secreting uric acid in the bloodstream, making it impossible to excrete uric acid.

High levels of uric acid can also lead to other diseases. In the past ten years, there has been an increase in the number of gout patients who were relatively rare in the past, and it has become a common disease not only in middle-aged and elderly people, but also in younger people. The reason for this can be said to be that they eat too well and do not pay attention to self-care.

Therefore, it is known as the "disease of wealth".

Gout is a metabolic disease caused by the metabolism of a substance called purines in the human body, resulting in an increase in uric acid in the blood. So, who is susceptible to gout? Genetic factors.

Gout is a hereditary metabolic disease with a genetic predisposition, and people with a family history of gout are prone to gout if they do not pay attention to eating and drinking. This is because there is a lack of an enzyme in the body, which cannot completely break down proteins, and the purines accumulate too much in the body, and the uric acid in the blood also increases and forms crystals, which are deposited in the joints, causing inflammation and causing severe pain.

The main reason for high uric acid is the disorder of purine substance metabolism in the human body, uric acid is the end product of purine metabolism, which is mainly broken down by nucleic acids and other purine compounds metabolized by cells, as well as purines in food, under the action of enzymes.

Mainly endogenous purine metabolism, and exogenous purine metabolism, the increase in blood uric acid is mainly caused by the decrease in uric acid excretion or excessive uric acid, but also includes the decrease in renal tubular secretion, urate crystal deposition, and decreased renal tubular secretion is the most important.

The increase in uric acid production is mainly due to enzyme deficiencies, including an increase in phosphoribose pyrophosphate synthase activity, an increase in the concentration and activity of phosphoribopyroxyltransferase, a partial deletion of guanine phosphoribosyltransferase, and an increase in xanthine oxidase activity. Nowadays, high uric acid is a very common phenomenon, and the age of onset tends to be younger, which has a lot to do with the usual dietary habits, this situation of elevated uric acid is called hyperuricemia, and the kidney function shows that uric acid is greater than 420umol l.

There are two problems to consider when uric acid rises, one is excessive uric acid production in the body, and the other is impaired uric acid excretion. The main reason is the poor eating habits, such as excessive intake of high-purine vision, staying up late to drink alcohol, and drinking less water after exercise.

Lifestyle changes can be made with drugs that promote the excretion of uric acid.

Introduction: High uric acid is not only complicated, but also very difficult, so the best way to prevent high uric acid is to understand the reasons for high uric acid and take necessary measures, so what is the reason for high uric acid? Let me introduce it to you!

Causes of high uric acid are 1

If the metabolism of purines in the human body is abnormal, it will often lead to an increase in uric acid.

The ** of uric acid in the human body is not only metabolized by the external diet, but also the excessive production of endogenous purines is also the cause of high uric acid.

1. Excessive metabolism of exogenous purines, the amount of uric acid produced in the human body is proportional to the intake of exogenous purines, uric acid is generated by nucleotide metabolism, and nucleic acids exist in the DNA and RNA of the nucleus.

Generally, it is highest in animal cells, poultry, and aquatic products, so it is better to eat as little as possible in daily life.

2. Endogenous purines are produced excessively, compared with endogenous purines in the human body, endogenous purines are more important than exogenous factors, and the amount of uric acid generated by endogenous purine metabolism is much higher than that generated by exogenous purines.

The second reason for high uric acid is two

The metabolism of purine substances in the body is disordered, resulting in a continuous decrease in uric acid excretion, and more patients will have abnormal renal processing urinary function'Phenomenon.

Abnormal renal metabolism, such as glomerular absorption and tubular reabsorption, can cause abnormal uric acid metabolism, and abnormal kidney function may be congenital or acquired, which is relatively rare.

There are three reasons for high uric acid

If these two causes exist at the same time, it will be more likely to lead to high uric acid.

Causes of high uric acid are four

Other factors contribute to high levels of uric acid.

For example, strenuous exercise, excessive diet, mental stress, excessive alcohol intake, etc., will cause an increase in uric acid; When you sweat a lot and don't have enough water in your body, the amount of urine excreted decreases, or your kidneys are weakened, so you can't excrete uric acid, and your uric acid level rises quickly.

High uric acid is a very common phenomenon, high uric acid may be caused by a variety of diseases, so we should pay attention to it, find the cause in time, and then prescribe the right medicine, so I will talk to you about what is the cause of high uric acid.

1.First, it is caused by abnormal excretion of visceral functions, and the kidneys are the main way to excrete uric acid, and when uric acid is not exhausted, the concentration of uric acid in the blood will increase. Professor Zhu believes that the reason why the human body exhibits high uric acid is mainly due to hyperuricemia caused by higher than normal uric acid concentration in the blood.

2.Second, high uric acid may be caused by inattention to diet, when uric acid is high, still do not pay attention to diet, usually eat more foods containing high purine content, such as various offal of animals, seafood, meat, beer, stay up late, socialize and other dietary behaviors, which can lead to the appearance of high uric acid.

3.Third, high uric acid may be caused by drugs, intoxication, or increased uric acid excretion and/or reabsorption by drugs, intoxication, or endogenous metabolites. This occurs when the anion transport system is inhibited, and two of the important inhibitors are lactic acid and ketoacids, so when the hands inhibit it, high uric acid occurs.

Precautions. If uric acid is too high, you must be more appropriate, control your diet, control your weight, eat more vitamin-rich fruits and vegetables, eat a low-fat diet, and prohibit eating spicy food.

If the patient finds that the blood uric acid level is elevated, it is necessary to pay attention to it, and it is necessary to go to a regular hospital for examination in time to avoid aggravating the condition.

Because there are many harms of elevated blood uric acid, such as the harm that may bring to the kidneys, if the blood uric acid is elevated, the patient may develop from gouty nephropathy to uremia, and in terms of method, it needs to be carried out by hemodialysis.

In addition, high uric acid may also bring cardiovascular and cerebrovascular system related diseases, such as hyperlipidemia, diabetes, hypertension, etc., which may be related to the level of blood uric acid, so the increase in blood uric acid level will bring more harm, such as common symptoms of gout attacks such as severe joint pain. The main causes of high uric acid are the disorder of the metabolism of purine substances in the body, which increases the synthesis of uric acid, and the disorder of the metabolism of purine substances in the body, which reduces the excretion of uric acid, or due to the coexistence of both.

For example, the main reason for the increase in uric acid synthesis is due to excessive intake of foods containing purines, such as seafood and alcohol, which can easily lead to purine metabolism disorders and increase uric acid synthesis.

Uric acid production can be increased in patients with kidney disease, such as if glomerular secretion is suppressed, glomerular filtration rate is reduced, tubular reabsorption is increased, and dehydration** or diuretics are given to patients with diabetes.

In addition, it is possible that both factors may be present at the same time, which can also lead to an increase in uric acid. For example, patients with hereditary lactose intolerance and glucose hexaphosphatase deficiency are prone to urinary retention and increased uric acid, which can lead to high uric acid.