What are the dangers of lupus erythematosus? What causes lupus erythematosus?

It affects the work and life of patients, and causes a huge financial burden on individuals and families.

Skin rashes and long-term use of hormones cause changes in appearance, causing psychological stress and affecting social and interpersonal relationships.

The hazards of lupus erythematosus are as follows:

Clause. 1. Lupus patients will have pathological changes in the kidneys, including urine protein, and urine red blood cells are positive.

Clause. 2. Some patients will have renal insufficiency and hypertension.

Clause. 3. Some patients will have hematologic changes, such as low white blood cells, which may cause a lack of granulocytes and very serious infections; Some patients develop anemia and thrombocytopenia.

Clause. 4. Some patients will have respiratory changes, including pleural effusion, and diffuse alveolar hemorrhage, and respiratory failure.

Clause. 5. Some patients will have cardiac insufficiency and symptoms of heart failure.

Clause. 6. Some patients also have neurological symptoms, including epilepsy.

The harm of lupus erythematosus is mainly seen in the decline of the function of important organs. Because lupus erythematosus is a systemic autoimmune disease, patients can have damage to multiple organs such as kidneys, lungs, heart, nervous system, and blood system. If drugs are not applied in a timely manner** in the early stage, patients may develop kidney damage as the course of the disease prolongs, leading to rapidly progressive glomerulonephritis and even acute renal failure, which seriously affects the quality of life of patients.

If the blood system is involved, life-threatening thrombocytopenic purpura major or hemolytic anemia may occur. Involving the central meridian system, cerebral thrombosis, epilepsy or cognitive dysfunction can occur, and lupus erythematosus can only be prevented from involving important organ functions if it is diagnosed early and drugs are used rationally.

The biggest harm in lupus erythematosus patients is multisystem damage, because the disease is ultimately autoimmune disease. The idea that autoimmune disease is definitely my low immunity is wrong, and it is actually an autoimmune disorder of the body. It is equivalent to saying that there will be civil strife, which does not mean that there is no strength or inability to defend against external enemies, but that it is the identification of oneself with oneself, including that one's own body is made an enemy by one's own antigen.

So I contradict myself, in this case it is called immune disorder, there will be damage to the organs of the whole body, the most critical is the kidneys, brain, sometimes lupus nephropathy, lupus subtype is more serious, the second lupus encephalopathy will appear mental nervous system damage, similar to what we say psychosis, mania, depression, at the same time, the damage of the blood system is similar to blood disease, which is the most important manifestation, and at the same time, it has a more acute onset in this area, and the damage to the body is relatively large.

The dangers of lupus erythematosus are manifold. Patients with mild symptoms will have fever, rash, photophobia, hair loss, mouth ulcers, and joint pain; In severe cases, hematuria, proteinuria, and even kidney damage may occur; There will also be polyserous effusion, pericardial effusion, ascites effusion, and even lupus encephalopathy, lupus lung disease, lupus enteritis, and severe lupus can even be life-threatening.

Most of the lupus erythematosus talked about is systemic lupus erythematosus, what is systemic, it is very characteristic of multi-organ damage, that is, in a patient, often in a short period of time, there will be multiple organs, that is, more than three organs of damage. The most common damage to organs, for internal organs, is the kidneys account for more than 50% of the 60% of the population, in addition to the kidneys, such as **, liver, blood, lungs, central nervous system, all of these organs may be damaged. Therefore, it is a severe, complex disease characterized by multi-organ damage.

In the active phase of systemic lupus erythematosus, patients mainly die from infections and severe multi-organ damage, especially neurological and renal damage; In the remission period, patients mainly die of chronic renal insufficiency, pulmonary hypertension and long-term use of hormones, such as infection, atherosclerosis, etc.

**Lupus erythematosus If there is no visceral involvement, the prognosis is good; However, some types of ** lupus erythematosus can be combined with visceral damage and even develop into systemic lupus erythematosus, and the prognosis will be similar to that of systemic lupus erythematosus, which may affect the quality of life and even threaten life.

1.Genetic factors. The onset of systemic lupus erythematosus tends to run in families.

2.Environmental factors. If exposed to ultraviolet rays, it can trigger or aggravate systemic lupus erythematosus, which may damage keratinocytes and form immune complexes that cause damage.

3.Sex hormone. It is more common in women of childbearing age, and pregnancy may induce the disease or worsen systemic lupus erythematosus.

4.Infectious factors. For example, Epstein-Barr virus (herpes virus) and streptococcal infections can induce or worsen the disease.

Lupus erythematosus is a typical autoimmune connective tissue disease, which can be divided into subtypes such as discoid lupus erythematosus, systemic lupus erythematosus, deep lupus erythematosus, and drug-induced lupus erythematosus.

Lupus erythematosus is an autoimmune disease, which is a spectrum of disease, with discoid lupus erythematosus at one end, the lesion is confined to **, and the other end is systemic lupus erythematosus, which can involve multiple systems of internal organs with ** damage. When the skin of people is infected, the bacteria will enter the body of the person through the wound, affect the internal organs of the patient, and cause lupus erythematosus disease. Lupus erythematosus is the result of abnormal immune regulation due to the interaction of genetics, viral infections, environmental factors and hormones, which change the structure of its own tissues and cells or mutations in immune cells, thereby losing its own tolerance.

If the autoimmunity is strong, it will have a good resistance to germs and will not be easy to get sick, while if the autoimmunity is low, the germs will be easily infected. Hope it helps!

** type of lupus erythematosus is more common in women, with young and middle-aged women as the main manifestations, and can be manifested as two types on **, first: it can show annular or multi-annular lesions, mainly edematous erythema or plaques, gradually expanding to the periphery, and showing a ring or arc. Adjacent lesions may coalesce into a polycyclic or gyrus with red raised margins, may be covered with fine scales on the medial,** and usually remain pigmented or telangiectasias.

Type II: Generally papules, scaly, small red papules at the beginning, gradually enlarged, maculopapular rashes of different sizes, covered with thin scales, it has no follicular embolism and adherent scales.

Systemic lupus erythematosus affects multiple systems, it can affect multiple organs, and multiple organs can be damaged. It can affect ** and joints on the surface, and internal organs can involve the heart, lungs, kidneys, blood, and nerves, so it is a disease with multi-system involvement. If it affects the blood system, leukopenia, erythrocytopenia, thrombocytopenia can occur.

If the kidneys are involved, proteinuria, hematuria, facial edema, and edema of both lower extremities may occur.

If the joint is affected, swelling and pain may occur. If it is involved, it can be typical of butterfly spots on the face. Why is it called lupus erythematosus?

It is that it has a typical facial rash on the face of some patients, which is distributed on the face in the form of a butterfly, and the origin of its name is this. It can also present with a variety of rashes, which do not necessarily have to be butterfly-shaped. In addition, if it affects the nervous system, it can even have various manifestations of mental disorders, mania, and depression, so its manifestations are varied.

If the heart is involved, a variety of manifestations can occur, including pericardial effusion, arrhythmias, valvular heart disease, and even coronary ischemia. If the lungs are involved, a variety of manifestations of pleural effusion, interstitial pneumonia, and lupus pneumonia can occur.

1.It will make ** very bad2As the disease drags on, internal organ lesions may occur3Severe can be life-threatening4It can cause some mental damage.

It will lead to a decrease in the body's immunity, causing damage to the body's organs, if not in time, uremia, heart failure, anemia, mental abnormalities may occur, after the discovery must go to the hospital in time, the right medicine, timely.

It will cause serious damage to the human body, and it will also be very painful, unbearable, sometimes it will crack and bleed, there will be many diseases, and it will also cause some infections, which is difficult to **.

It may cause people to become more and more sensitive, and then there may be anemia, which may affect blood circulation, may affect the mucous membranes, and may affect the respiratory system and kidneys.

The human body will experience weakness in the limbs, loss of appetite, pain, itching and lack of sleep.

During this time, very purple-red patches appeared on the body inexplicably, which were not many at first, but within a few days, they were covered in many places, and when I went to the hospital for examination, the doctor said that I had lupus erythematosus. Let's learn what causes lupus erythematosus.

1.The first aspect: lupus erythematosus is one of the autoimmune diseases, which belongs to the scope of connective tissue diseases, which are divided into discoid lupus erythematosus (DLE), systemic lupus erythematosus (SLE), subacute ** lupus erythematosus, deep lupus erythematosus and other types.

2.The second aspect: the first aspect of lupus erythematosus has genetic factors, infectious factors, endocrine factors, and environmental factors. Among them, genetic factors are important factors in the pathogenesis, and long-term ultraviolet radiation and indiscriminate use of drugs can directly induce lupus erythematosus.

3.The third aspect: lupus erythematosus is caused by immune disorders, not genetic diseases, but in the predisposing factors, drugs, environment, pregnancy, endocrine, and heredity are all triggers, so lupus erythematosus has a certain genetic tendency, but if you are pregnant during the stable period of the disease, it is generally not hereditary.

Precautions. Lupus erythematosus patients are effectively controlled, and their condition is completely controllable and stable, so patients and their families must have confidence and actively cooperate.

First, the cause of the occurrence is related to genetic factors.

Second, it is related to sex hormones, which is more common in women of childbearing age, and pregnancy can aggravate or induce the occurrence of systemic lupus erythematosus.

Third, related to environmental factors, UV exposure can provoke and aggravate lupus erythematosus, which may damage keratinocytes

Lupus erythematosus is a typical representative of connective tissue disease, the incidence is higher than that of other connective tissue diseases, this disease is a spectrum disease, one end of the spectrum is discoid lupus erythematosus, the lesion is mainly limited to **, lupus erythematosus is divided into three types: discoid lupus erythematosus, subacute ** lupus erythematosus and systemic lupus erythematosus. 1.

Discoid lupus erythematosus.

The damage mainly violates **, the age of onset is mostly young and middle-aged people in 20 and 40 years, more women than men, and the most common parts are mainly exposed parts, such as the face, nose bridge, cheeks, symmetrical distribution, like a butterfly, followed by the lips, ears, back of the hands, forehead, scalp, etc. The rash is persistent discoid erythema, with clear boundaries and a slight elevation on the skin surface, which is covered with a thick layer of adhesive scales, which is not easy to peel off, if the scales are peeled off vigorously, most of the spiny keratin plugs can be seen on the bottom surface of the scales, and the hair follicle opening at the bottom of the rash is significantly enlarged, which corresponds to the keratin plugs on the scales. Over time, the damage ** gradually atrophies, the center is depressed, telangiectasia is visible, hypopigmentation, and a dark red halo of darkened pigmentation is encircled around the edges.

The edges are red, sometimes erosive, forming shallow ulcers and eventually atrophy. In a small number of patients, the rash is extensive, affecting the head, face, limbs, trunk, etc., and is called disseminated discoid lupus erythematosus. Occasionally, discoid lesions are markedly elevated and wart-like on the surface, called hypertrophic lupus erythematosus.

Systemic symptoms are rare, and some patients may have low-grade fever and arthralgia as the disease progresses. The course of the disease is slow, can last for years to decades, a small number of patients on the basis of chronic lesions, can develop **calcinosis, basal cell carcinoma or squamous cell carcinoma, there are also keratoacanthomatoma, 1% 5% of DLE can be transformed into subacute ** lupus erythematosus The ** damage of the disease is widely distributed in the face, neck, trunk, shoulder, and can extend to the forearm and back of the hand. The lesions are superficial, without atrophic scars, and are characterized by papular plaques overlying scales that resemble psoriasis, or are annular, multi-annular, erythema, telangiectasias, and well-defined.

3.The early manifestations of systemic lupus erythematosus are varied. The initial attack may involve only a single organ, such as **, kidneys; or multi-system simultaneous involvement.

Systemic symptoms such as fever, fatigue, tiredness, weight loss, etc. Joints and ** are the most common early symptoms of the disease, followed by fever, light sensitivity, Raynaud's phenomenon, nephritis and serositis.