What are the early symptoms of glioma?

1. Headache: About 30% of glioma patients present with headache, and about 70% of them will gradually worsen their headache. Most of these headaches are nonspecific, but intermittent, mostly on the same side of the lesion, and often present as a dull ache rather than a throbbing pain, and are sometimes not easily distinguishable from tension headaches.

Gliomas usually present with pain in the forehead, while gliomas in the cerebellum tend to present with pain in the occipital and neck. If the tumor is too large and produces high intracranial pressure, the headache is significantly worsened, sometimes awakened by pain during sleep, and significantly worse when the head is vigorously moved, sometimes accompanied by nausea and vomiting. If intracranial hypertension persists for too long, there may also be signs of vision loss.

2. Mental changes: About 15-20% of glioma patients have changes in mental status as the first symptom, which is mainly manifested as changes in mood, personality, cognitive function, calculation and memory.

3. Focal neurological symptoms: different locations of tumors can also cause corresponding nerve loss symptoms, such as paralysis of limbs, sensory impairment, aphasia, unsteady gait, hemianopia, dyslexia and agraphia.

4. Cranial nerve symptoms: Different cranial nerve damage will produce corresponding neurological symptoms, such as decreased vision, diplopia, squint and facial paralysis.

In general, gliomas can present with all the symptoms of neurological disorders, but not all symptoms will appear in a single person, and these early symptoms can vary depending on the type of tumor, tissue characteristics, location and speed of growth. Therefore, it is best to have glioma as early as possible.

The signs and symptoms of glioma depend on the mass effect and the function of the brain region affected. Gliomas are due to their "mass" effect in space (mass

effect), which can cause symptoms such as headache, nausea and vomiting, epilepsy, and blurred vision. In addition, due to its effect on local brain tissue function, patients can also develop other symptoms. For example, optic nerve gliomas can cause loss of vision; Spinal glioma can cause symptoms such as pain, numbness and weakness in the limbs; **Gliomas can cause motor and sensory disturbances; Gliomas in the language area can cause difficulties with language expression and comprehension.

Depending on the degree of malignancy of glioma, the rate at which symptoms develop varies. For example, patients with low-grade gliomas tend to have a history of months or even years, while patients with high-grade gliomas tend to have a history of weeks to months. Based on the patient's medical history, symptoms, and signs, the location of the lesion and the degree of malignancy can be preliminarily inferred.

However, the final positioning and qualitative diagnosis should also consider other examinations, including magnetic resonance and the final diagnostic criteria - pathological diagnosis.

—The above information** is self-———

Name of the tertiary hospital]--Beijing 304 Hospital Neuro-Oncology ** Center ---Tumor ** Technology] --DC-CIK Biological Immunity**.

The early symptoms of gliomas are usually subtle and progress at different rates depending on the grade, with symptoms gradually appearing over months or years in low grades, as follows:

1. It usually manifests as headache, nausea, vomiting, and some patients will have epilepsy;

2. Glioma grows near the ** groove of the functional area, and motor and sensory impairments may occur. People with optic nerve gliomas experience visual impairment. Gliomas grow in the language area, and language expression and comprehension can be impaired.

Patients with symptoms such as early morning headache, projectile vomiting, epilepsy, memory impairment or speech impairment are advised to seek medical attention and confirm the diagnosis**.

Gliomas rank first in the incidence of neurological tumors. According to the WHO classification, it is divided into 4 grades: grade I and grade II gliomas have slower cell growth, also known as low-grade gliomas; Grades III and IV, which grow rapidly, are defined as high-grade gliomas.

In recent years, with the development of sequencing technology and big data analysis, the classification of glioma tends to rely more on molecular pathological classification, which has important practical significance for the biological characteristics, best strategies and prognostic judgment of tumors, and is conducive to the development and popularization of personalized diagnosis and treatment.

But today, we still have to start with glioma classification, after all, this classification is relatively mature:

So what is a low-grade glioma?

1.Pilocytic astrocytoma.

The medical term is abbreviated as "Mao Xing", and this subtype specifically targets young people under the age of 25, but it is the slowest and slowest in development, and can be said to be one of the few "malleable talents" in glioma.

2.Diffuse astrocytoma.

The most common low-grade glioma, which tends to occur in people between the ages of 35 and 40, is divided into two subtypes depending on whether there is an IDH gene mutation (more on this later);

3.Oligodendroglioma.

This guy is characterized by both a mutation in IDH and a codeletion of 1p 19q, and the tumor grows very slowly;

4.Gangliocytic glioma.

These rare tumors are mixed with glioma and neuron** tumor components and generally do not grow quickly. In summary, although few of these tumor patients are completely aware, most of them can work, study and live normally and have a high quality of life as long as they actively cooperate and control secondary epilepsy, cerebral edema and related complications.

Absolute demon – high-grade glioma.

Anaplastic astrocytoma.

Anaplastic oligodendrogliomas and anaplastic ependymomas, which are classified as WHO grade III;

Glioblastoma, which belongs to WHO grade IV.

In addition, there are mixed gliomas in which there are two types of tumour cells (oligodendrocytes and astrocytes**): oligodendroastrocytomas (grade II) and anaplastic oligoastrocytomas (grade III).

The symptoms of glioma have some things in common with those of other brain tumors. Symptoms such as headaches, vomiting, and seizures are usually caused first. Therefore, when headache and vomiting occur, it is not immediately judged as a symptom of glioma, but can only be diagnosed through clinical examination and pathological diagnosis.

Let's give you a detailed introduction to the symptoms of glioma.

Symptoms of Glioma:

1. Headache: The first symptom of glioma is headache, which is caused by the compression and involvement of painful and sensitive structures in the skull after the increase in intracranial pressure, such as blood vessels, dura and some cranial nerves.

2. Vomiting: Vomiting occurs when the headache is severe, which is projectile. However, in children, headache may be subtle due to craniosynostomy, especially in posterior fossa glioma, where vomiting is the most pronounced.

3. Epilepsy: Some symptoms of glioma are the first or early main symptom of epilepsy. Brain tumors should be considered if epilepsy begins in adulthood and is not easily controlled by medication or the nature of the seizures is altered.

4. Psychiatric symptoms: Mental abnormalities are symptoms of frontal glioma, which can be manifested as personality changes, apathy, decreased speech and activities, poor concentration, memory loss, lack of care about things, and lack of neatness.

5. Local symptoms: the corresponding symptoms will be produced according to the location of the tumor, and the symptoms will be progressively aggravated. The local symptoms of malignant gliomas are very pronounced and develop rapidly.

After the tumor enlarges, the intracranial pressure increases, and symptoms such as headache and vomiting appear. If you only find out at this time, it is relatively difficult and the effect is relatively poor. When it occurs in other functional areas, there may be visual loss, visual field changes, seizures, and unsteady walking.