How was EDTA discovered?

The synthesis of such substances is mainly based on Mannich condensation, which links alkyl groups to amine groups, and then to carboxyl groups, so a look at the history of the Mannich reaction should be able to find the relevant development process. (I'm an organic scumbag, and I'm not sure if I'm right about synthesis, so please correct the organic god.) There are many similar ammonia carboxyl complexes, such as:

Amine triacetic acid (TEA) Isopropyldiaminetetraacetic acid (IPDTA) Ethylenediaminetetrapropionic acid (EDTP) Cyclohexanediaminetetraacetic acid (DCTA) Diethyl etherdiaminetetraacetic acid (EEDTA) Ethylene glycol diethylethertetraacetic acid (EGTA) The molecular formula is too lazy to draw, you can. In addition to the carboxyl group, the amine group can also be a phosphate group, such as ethylenediamine tetramethyl fork phosphate, which is a water treatment agent that is still widely used. All of the above have strong complexation capabilities, but EDTA is the most widely used.

EDTA, as a multi-valent weak acid, will have a good complexation effect for 2-valent and 3-valent metal cations, effectively reduce the ion concentration of free metal cations, and stabilize pH by the way (although this is not the main purpose, but it really has this effect, you can use EDTA buffer yourself to know the ...... of pH toneThe presence of a lot of metal cations is not good news for the preservation of some biological macromolecules, such as RNA DNA, reducing the concentration of plasma such as ca mg mn can effectively extend the shelf life of these molecules, in addition, EDTA can also be used to abolish some enzymatic reactions, after all, so many enzymes need metal cations to participate in order to work normally, if you do sequencing-related experiments, you will find that various instructions often say, do not dissolve nucleic acids in TE buffer, TE will affect the sequencing results. <>

1. Ethylenediaminetetraacetic acid (EDTA) is an organic compound with a chemical formula of C10H16N2O8, which is a white powder at room temperature and pressure.

2. It is a chelating agent that can bind to divalent metal ions such as Mg2+, Ca2+, Mn2+, Fe2+, etc. Since most nucleases and some egg white enzymes require Mg2+ before the effect, Huiqingkong is often used as inhibitors of nucleases and proteases; It can also be used to remove the inhibition of enzymes by heavy metal ions.

EDTA is ethylenediaminetetraacetic acid

Ethylenediaminetetraacetic acid (EDTA) is an organic compound with the chemical formula C10H16N2O8, which is a white powder at room temperature and pressure. It is a chelating agent that can bind to Mg2+, Ca2+, Mn2+, Fe2+ and other divalent metal ions. Because most nucleases and some proteases require Mg2+, they are often used as inhibitors of nucleases and proteases; It can also be used to remove the inhibition of enzymes by heavy metal ions.

Uses:

EDTA is an important complexing agent. EDTA has a wide range of applications and can be used as a bleaching fixer, a dyeing auxiliary, a fiber treatment auxiliary, a cosmetic additive, a blood anticoagulant, a detergent, a stabilizer, and a polymerization initiator for synthetic rubber.

EDTA is a representative substance of chelating agents. It can form stable water-soluble complexes with alkaline earth metals, rare earth elements and transition metals. In addition to sodium salts, there are ammonium salts and.

Iron, magnesium, calcium, copper, manganese, zinc, cobalt, aluminum and other salts, each of which has different uses.

In addition, EDTA can also be used to rapidly excrete harmful radioactive metals from the human body and play a detoxifying role. It is also a water treatment agent. EDTA is also an important indicator, but it is used to titrate metal nickel, copper, etc., and it must be used with ammonia to play the role of an indicator.

EDTA is an important complexing agent. EDTA has a wide range of uses, and can be used as a bleaching fixer, a dyeing auxiliary, a fiber treatment auxiliary, a cosmetic additive, a blood anticoagulant, a detergent, a stabilizer, and a synthetic rubber polymerization initiator. It can form stable water-soluble complexes with alkali metals, rare earth elements and transition metals.

Name. Chinese name: ethylenediaminetetraacetic acid.

edta[1]

Chemical name: ethylene

diamine

tetraacetic

acid。Chemical abbreviation: EDTA Chinese alias:

Diaminoethylene tetraacetate, supporting ruler grip briton. Common name: edetic acid (especially its calcium salt complex, medically known as sodium calcium edetate).

Product Name: ethylenediaminetetraacetic

Synonyms for acid: (ethylenedinitrilo)tetraacetic

acid,edathamil [linear molecular formula. (hocch

nchchn(ch

COH) molecular formula. chno

Molecular weight. Note: EDTA disodium is: [CAS number.]

60-00-4 [density.

g cm3 [melting point.]

250 [Storage.

Keep tightly sealed. Hope it works for you.

White odorless and odorless bridging, colorless crystalline powder, melting point 240 (decomposition). Insoluble in cold water, alcohol and general organic solvents, slightly soluble in hot water, soluble in sodium hydroxide, sodium carbonate and ammonia solution, soluble in 160 parts of 100 boiling water. Its alkali metal salt can be dissolved in water, and the solubility of sodium salt in water is shown in the following table (g l).

Sodium salt of ethylenediaminetetraacetic acid is generally used instead of EDTA

Uses: It is an important complex song. EDTA has a wide range of uses, and can be used as a bleaching fixer, a dyeing auxiliary, a fiber treatment auxiliary, a cosmetic additive, a blood anticoagulant, a detergent, a stabilizer, and a polymerization initiator for synthetic rubber. It can form stable water-soluble complexes with alkali metals, rare earth elements and transition metals.

In addition to sodium salts, there are ammonium salts and various salts such as iron, magnesium, calcium, copper, manganese, zinc, cobalt, and aluminum, each of which has different uses. In addition, EDTA can also be used to rapidly excrete harmful radioactive metals from the human body and play a detoxifying role. It is also a water treatment agent.

In the food industry, it can be used as a chelating agent in the food industry such as canned food processing to drive away the interference of Jin Min Sakura ions.

EDTA is an important complexing agent. EDTA is widely used as a bleaching fixer for the processing of color photosensitive materials, a dyeing auxiliary, a fiber treatment auxiliary, a cosmetic additive, a blood anticoagulant, a detergent, a stabilizer, and a synthetic rubber polymerization initiator. It can form stable water-soluble complexes with alkali metals, rare earth elements and transitional gold.

Chinese name: ethylenediaminetetraethyl acid (EDTA), pt

Molecular weight.

Ethylenediamine four attacks annihilation acetic acid.

Divide and change the royal formula: C10H16N2O8

Molecular weight.

cas no： 60-00-4

Physicochemical properties of EDTA: EDTA is a white crystalline powdery pat wheel solid, acidic, insoluble in cold water, slightly soluble in hot water; Soluble in alkaline (such as sodium hydroxide, ammonia) aqueous solution.

Applications: As a chelating agent, it is widely used in industrial water treatment, boiler cleaning, oilfield well washing, chemical analysis, chelating trace element fertilizers, daily chemical additives, photographic chemicals, etc.

It is disodium EDTA, if you say that this product is also marked with concentration specifications before making regrets, for example, then this is the disodium EDTA standard solution, and the accuracy of the standard solution will be more pure. It is generally used for titration analysis in the laboratory of Qianxin. That's what our company does.