How to reduce the incidence of polycythemia vera in life

Hello, avoid exposure to environmental pollution, chemical factors, etc., maintain good living habits, and eat and rest reasonably.

Polycythemia vera (PV), abbreviated as polycythemia vera, is a clonal chronic myeloproliferative disease dominated by abnormal red blood cell proliferation. The total peripheral blood volume is absolutely increased, the blood viscosity is increased, and it is often accompanied by an increase in leukocytes and blood cells, splenomegaly, and complications such as bleeding and thrombosis may occur during the course of the disease. The clinical features include ** mucosal redness and purple, hepatosplenomegaly, vascular and neuropathic symptoms, insidious onset, and slow progression of the disease.

The annual incidence is 10,000 people, and the peak incidence is concentrated between 50 and 60 years old, so it is a middle-aged and senile disease. Exam big ** sorting.

Males are slightly more affected than females.

and pathogenesis.

True erythroid clonal hematopoietic stem cell disease is caused by the pathological proliferation of a hematopoietic stem cell. The evidence is that the two eu-red patients were also heterozygous for glucose-6 monophosphate dehydrogenase (G-6-PD) deficiency, and that the patient's tissues that were not affected by eured such as ** and fibroblasts had type A and type 8 G6-PD, while the affected erythrocytes, granulocytes, and megakaryocytes had only one type (type A) G-6-PD, confirming that the affected cells were derived from a hematopoietic stem cell. However, the pathogenesis and pathogenesis have not been elucidated.

Thrombotic complications associated with true red are mainly due to increased hematocrit, activation of leukocytes and platelets, and increased blood viscosity.

True red is a clonal, progressive, unexplained bone marrow proliferative disorder with predominantly erythrocyte proliferation, often accompanied by leukocyte and thrombocytosis.

It begins with an increase in red blood cells and hemoglobin, then enters the myelofibrosis phase, and then the anemia phase with splenomegaly, myeloid metaplasia, and pancytopenia. A small number can turn into leukemia. If the diagnosis is confirmed, you need to go to the hospital for a bone puncture examination.

Bye-bye polycythemia vera (PV) is a clonal chronic myeloproliferative disorder of hematopoietic stem cells. PV has an insidious onset and progresses slowly, usually through two stages of progression: Proliferative or erythrocytosis Erythrocytosis is common; Late erythrocytosis manifests as pancytopenia, extramedullary hematopoiesis, hepatosplenomegaly, hypersplenism, and myelofibrosis.

Hemorrhage and thrombosis are the two main clinical manifestations of PV, and a small number of patients can progress to acute leukemia.

Polycythemia vera is diagnosed by blood examination, bone marrow examination, arterial oxygen saturation measurement, etc.

Basis for diagnosis. 1.Clinical manifestations of polyemia.

2.Hemoglobin measurement and red blood cell count are markedly increased.

3.Increased hematocrit: male; Female.

4.There is no infection or other causes, and the white blood cell count is multiple times".

5.Platelet count is more than 300 1012 L on several occasions.

6.The bone marrow showed that the proliferation was obvious, and the granulocytes, erythrocytes, and megakaryocyte lines were all proliferated, especially the erythroid cells.

7.Secondary polycythemia is excluded, especially due to cardiopulmonary insufficiency, kidney, liver, cerebellum and ** tumors.

First of all, the number of peripheral blood is significantly increased, and it may also be accompanied by an increase in the number of white blood cells and platelets, and secondary causes need to be ruled out, such as large lung cysts, emphysema, and polycythemia due to physiological reactions to plateaus; Genetic tests such as JAK2 and MPN are then done to determine whether it is polycythemia vera.

Diagnosis of polycythemia vera can be made by history, clinical manifestations, and laboratory tests; Diagnosis is based on the exclusion of other types of polycythemia, such as some secondary polycythemias; Secondary erythrocytosis includes high-altitude erythrocytosis, neoplastic erythrocytosis, and erythrocytosis caused by smoking; In addition, diagnosis can be made by testing the level of hematocrit, bone marrow, genes, erythropoietin, etc.

Polycythemia vera is a hematologic abnormality in Human Genetic Sequence Changes and Human Disease Characterization. There are two main directions for clinical diagnosis and diagnosis. One is a routine blood test and the other is a genetic test.

There are many types of genetic testing, and some test a small number of genes and few gene loci. False-negative results can occur. False positives also exist.

The main basis for genetic testing is the Human Genetic Mutation Database, which mainly records the genetic mutations that have been discovered, but not all of them are clearly marked as if these mutations cause disease. Gene decoding is a tool that is essentially and methodically beyond data-based genetic information. It is characterized by the use of whole exome sequencing method, which obtains all gene mutations at one time, which avoids the loss of gene mutations caused by the selection of a small number of sequences in genetic testing packages, genetic testing**, genetic testing panels, and regional capture sequencing.

In addition, taking the structural basis of proteins and constituent substances in life activities as a means of analyzing genes, rather than checking the dictionary-style database comparison of primary school students, overcomes the limitations of database capacity, species, and regional differences, so that every detected mutation can be interpreted, thereby bringing a higher positive rate, a higher detection rate, and a better clinical performance, and the coincidence rate between the development process and gene mutations. Therefore, genetic testing or gene decoding should be used to determine true red disc hyperplasia, and gene decoding is better than genetic testing.

Polycythemia vera, abbreviated as euphoria, is a disease of unknown cause, chronic progressive bone marrow hematopoietic activity is generally hyperactive, and belongs to myeloproliferative syndrome. In the early stage, there may be no symptoms or only fatigue, weakness, dizziness, etc. Signs include hepatosplenomegaly, dark red with mucous membranes, most obvious on the lips, tip of the nose, earlobes, palms and conjunctiva, and the appearance is like a drunken appearance.

Gua sha site] 1 head and neck: Fengchi, Fengfu, Yintang.

2 abdomen: mid-navel.

3. Upper limbs: Quchi, Neiguan, Shenmen.

4 lower limbs: Zusanli, Yinling Spring, Sanyinjiao.

**Best way to answer for polycythemia vera: Ren Licun's polycythemia vera is a clonal stem cell disorder characterized by hypervolemia, increased blood viscosity, and splenomegaly. It is more common in older people.

**The goal is to bring blood volume and red blood cell volume close to normal as soon as possible, inhibit bone marrow hematopoietic function, thereby alleviating the condition and reducing complications. Generally, it is phlebotomy, chemotherapy and interferon application.

Is there a specific drug for polycythemia vera now Answerer: Hello Liu Xingzhi, there is no specific drug for this situation, you can take carylurea tablets**, and if the platelets are normal, you can apply phlebotomy**.

Your situation requires an in-person physical examination and auxiliary examination to clarify the ** plan, which cannot be done through online consultation, so it cannot be accurately judged. It is recommended to go to the hospital for a detailed examination to determine the ** plan.

Disease analysis: polycythemia vera is a chronic myeloproliferative disease dominated by abnormal proliferation of erythroid cells with clonal disorder of pluripotent hematopoietic stem cells, and is a rare disease guidance: phlebotomy is still recommended as the preferred method for this disease.