Why does myasthenia gravis occur?

External environmental factors are one of the causes of myasthenia gravis, such as environmental pollution can cause a decline in the immune system, overexertion can cause the body's immune function to be disordered, and myasthenia gravis can be induced; Viral infections or the use of certain antibiotic drugs can trigger certain genetic defects.

Clinical findings show that immunity is weakened by certain environmental factors such as environmental pollution; Excessive exertion constitutes immune dysfunction, which can easily lead to the emergence of myasthenia gravis; Viral infections or myasthenia gravis, such as certain genetic defects induced by drugs**.

In recent years, many autoimmune diseases have found that they are not only closely related to the often histocompatibility antigen complex genes, but also the incompatible antigen complex genes, such as T cell receptors and immunoglobulins, cytokines, apoptosis and other genes. For this reason, this is also the main factor that predisposes to the detection of myasthenia gravis.

The causes of myasthenia gravis include abnormalities of the autoimmune system, and clinical observation shows that many immune indicators in patients with myasthenia gravis are abnormal, and the clinical symptoms disappear after diagnosis and treatment, but the abnormal immune indicators do not change, which may be an important factor in the instability of myasthenia gravis, which is more likely to attack.

Myasthenia gravis can be caused by muscular dystrophy, diseases of nerve endings, thymoma, etc. Abnormalities in the patient's autoimmune system are an important cause of this disease, and it is also the main one. Genetics is also an important cause of myasthenia gravis.

There are also some external factors in myasthenia gravis, mainly including external environment and diet. All of them belong to myasthenia gravis**.

Immunity is weakened due to certain environmental factors such as environmental pollution; Excessive exertion constitutes immune dysfunction, which can easily lead to the emergence of myasthenia gravis;

Myasthenia gravis is an autoimmune disease, which is related to autoimmune dysfunction, and the postsynaptic membrane acetylcholine receptor of the neuromuscular junction is attacked by autoantibodies to cause muscle weakness symptoms, which is also closely related to genetic factors.

First, the main **.

1. Autoimmune dysfunction: This disease is mainly a humoral immunity-mediated disease, and its pathogenesis is that with the participation of complement, the ACHR antibody produced in the body and the ACHR of the postsynaptic membrane produce an immune response, so that the ACHR is damaged, so that it cannot produce enough endplate potential, and the postsynaptic membrane transmission disorder produces muscle weakness. Patients often have other autoimmune diseases, such as hyperthyroidism, thyroiditis, systemic lupus erythematosus, rheumatoid arthritis, and pemphigus.

2. Genetic factors: the discovery of familial myasthenia gravis and its close relationship with human leukocyte antigen (HLA) suggest that the onset of myasthenia gravis is related to genetic factors.

2. Predisposing factors.

1. Excessive fatigue and surgery: Surgery and overwork will cause decreased immunity or immune dysfunction, which can induce the occurrence of the disease.

2. Infection: common upper respiratory tract infections, lung infections and systemic infections.

The presence of myasthenia gravis has a great impact on the health of patients, and the onset of myasthenia gravis is not only in young people, but also in some elderly people. In life, we must have an understanding of myasthenia gravis, especially "what are the reasons for the occurrence of myasthenia gravis", and we can only effectively prevent myasthenia gravis by fully mastering the knowledge, and patients can also choose scientific methods based on knowledge.

What causes myasthenia gravis?

1. Myasthenia gravis has physical factors; Endocrine disorders, hyperthyroidism and other diseases can cause myasthenia gravis.

2. External environmental factors, such as environmental pollution, can cause a weakened immune system; Overwork causes the body's immune function to be disordered; Certain genetic defects are induced by viral infections or the use of certain antibiotic drugs.

3. Mental factors: Excessive fatigue occurs due to playing mahjong and computer games for a long time, so it is necessary to combine work and rest to maintain a comfortable mood. It is one of the ** myasthenia gravis.

Fourth, the patient's own immune system is abnormal, clinical studies have found that many immune indicators in the patient with this disease are abnormal, and the clinical symptoms disappear after the first pass, but the abnormal immune indicators have not changed, which may be an important factor in the instability and ease of the disease.

Myasthenia gravis is a relatively rare neurological disease, which is clinically manifested by extreme fatigue and general fatigue. At present, the cause of the disease is not clear, and from a medical point of view, it is believed that the human innervated muscles produce movement, and if there is a disorder at the junction of the innervated muscles, the nerve motor signal can not be successfully conducted. In addition, myasthenia gravis is currently speculated to be related to genetics, infection, and autoimmunity.

Thymic hyperplasia can be seen in some patients with myasthenia gravis, such as thymus disease**, myasthenia can also be resolved with a clear homeopathy.

1. Nerve and muscle junction transmission disorder is an autoimmune disease of acetylcholine receptors on the postsynaptic membrane at the neuromuscular junction.

2. Food contamination and poisoning: A considerable part of the patients are caused by eating unclean fried fritters, inferior drinks contaminated by chemicals, and some are caused by patients eating mushrooms.

3. Viral infection: This disease is related to immunocompromise and infection with thymic chronic disease virus.

4. Mental factors: Excessive fatigue is caused by playing mahjong and computer games for a long time, so it is necessary to combine work and rest to maintain a comfortable mood.

5. Other factors: hyperthyroidism, autoimmune diseases, polymyositis, lupus erythematosus, etc.

The cause of myasthenia gravis is considered to be thymus. Myasthenia gravis is an autoimmune disease that affects the transmission of neuromuscular junctions, and the exact pathogenesis is unknown, but studies on this disease confirm that the thymus gland is involved in the development of the disease, and it is possible that the thymus gland causes problems at the neuromuscular junction. The occurrence of this disease is generally closely related to the thymus, but it cannot be fully explained by thymic disease.

Then there's genetic predisposition. Myasthenia gravis has been found to have a family history of this disease. Other reasons are considered to be related to immunomodulatory mechanisms.

Therefore, the exact cause of myasthenia gravis is not clear, but for myasthenia gravis, the symptoms are more obvious, such as eyelid weakness, eye muscle weakness, dysphagia in severe cases, and symptoms may also occur in both upper arms and lower limbs. In addition, most patients may have eye muscles affected, resulting in severe symptoms.

1. In recent years, according to ultrastructural studies, myasthenia gravis is mainly caused by the lesion of acetylcholine receptor (ACHR) in the postsynaptic membrane.

2. Many clinical phenomena also suggest that the disease is related to the disorder of immune mechanism.

3. Myasthenia gravis is an autoimmune disease that affects the transmission of neuromuscular junctions, and its exact pathogenesis is still unclear, but there are still many studies on the disease, among which, the most studied is the relationship between myasthenia gravis and thymus, and the role of acetylcholine receptor antibodies in myasthenia gravis, and a large number of studies have found that the number of acetylcholine receptors (ACHR) on the postsynaptic membrane at the neuromuscular junction in patients with myasthenia gravis is reduced, and there are anti-ACHR antibodies at the receptor site. and the deposition of IgG and C3 complexes on the postsynaptic membrane.

It has also been shown that the increase in anti-ACHR antibodies in the serum and the decrease in the number of effective ACHR caused by the deposition on the postsynaptic membrane are the main causes of the disease. The thymus gland is the main site of ACHR antibody production, so the occurrence of this disease is generally closely related to the thymus. Therefore, regulating the number of ACHR in the human body, increasing its number, resolving the deposition on the postsynaptic membrane, and inhibiting the production of anti-ACHR antibodies are the key to this disease.

Pathological diagnosis of myasthenia gravis.

The pathological morphology of myasthenia gravis includes three parts: muscle fibers, neuromuscular junctions, and thymus.

1. Changes in muscle fibers: In the early stage of the disease, there are mainly lymphocyte infiltrates between muscle fibers and around small blood vessels, mainly small lymphocytes, which is called lymphatic leakage; In acute severe disease, there is coagulative necrosis of muscle fibers, accompanied by macrophage exudation of polymorphonuclear leukocytes; In advanced stages, muscle fibers may have varying degrees of optic nerve changes, and the muscle fibers are small.

2. Changes at the neuromuscular junction: The morphological changes at the neuromuscular junction are the most characteristic changes in the pathology of myasthenia gravis, which are mainly manifested in: the postsynaptic membrane fold disappears, flattens, and even breaks.

3. Changes in the thymus: about 30 patients with myasthenia gravis have thymoma, 40 to 60 patients have thymus hypertrophy, and more than 75 patients have central hyperplasia of thymus. Adenomas are classified according to their cell type:

Lymphocytic, epithelial, mixed-cell, the latter two are often associated with myasthenia gravis.