What are the side effects of paclitaxel chemotherapy? Can patients tolerate it?

In the process of tumor, paclitaxel chemotherapy is relatively common, and this method brings more ... For example, people may experience symptoms such as nausea, vomiting, hair loss, loss of appetite, etc., and may also cause physical pain or poor mental state. The following will introduce the manifestations of paclitaxel chemotherapy*** and ways to reduce paclitaxel chemotherapy***.

What are paclitaxel chemotherapy***?

1.Gastrointestinal reactions.

The reaction of paclitaxel to the human digestive tract is more common and more severe, and patients will experience nausea, vomiting, loss of appetite, and even abdominal pain, diarrhea, and make patients lose weight day by day.

2.Bone marrow suppression.

The use of paclitaxel will cause a lot of damage and reduction to white blood cells, platelets, low platelets, coagulation dysfunction, and patients will find unexplained bruising on the body. Leukopenia can lead to a decrease in the body's immunity, which can easily cause infections and symptoms of fever, inflammation and fatigue.

3.Anaphylaxis.

Some patients will have an allergic reaction to paclitaxel, and may have mild allergic reactions such as itching, rash, flushing, and increased blood pressure, and in severe cases, dyspnea, urticaria and anaphylactic shock, which need to be rescued immediately, otherwise it is life-threatening.

4.Hair loss. Hair loss is a problem that most chemotherapy patients will have to a greater or lesser extent, often occurring about 2-3 weeks after **, and some occur after several chemotherapy treatments, which may be gradual or clump at a time.

But patients don't need to be afraid, after the chemotherapy is over, there is no pharmacological reaction, and the hair will grow back.

How to alleviate the *** of paclitaxel chemotherapy?

In terms of diet, eating small, frequent meals, eating light and easily digestible foods, and eating small amounts of food frequently during the day can help resist nausea and vomiting associated with chemotherapy. Increase food diversity, rich in nutrients, and promote the improvement of appetite. You should pay more attention to keeping warm, add clothes according to the climate, pay attention to personal hygiene, and avoid infection.

Observe yourself for nosebleeds, bleeding gums, and if there is significant bleeding, you should seek medical attention immediately for further observation. With Dr. R&F's ginseng Baiyi, it helps to control the disease without deterioration and prevent the spread and metastasis of tumor cells. It can significantly improve the decline of white blood cells caused by radiotherapy and chemotherapy and surgery, alleviate adverse reactions, reduce toxicity and increase efficiency of radiotherapy and chemotherapy, and improve human body function and immune function.

Analysis:1Allergic reaction 2

Hematology: Myelosuppression is the major dose-limiting toxicity of paclitaxel. The most common hematologic adverse reaction was dose-related neutropenia, which occurred in 68% of patients.

In the first cycle of paclitaxel**, 58% of patients experienced severe neutropenia. Patients who have received prior radiotherapy or cisplatin** are more likely to have bone marrow suppression and are more severe. Thrombocytopenia has been reported to be less frequent and more severe after paclitaxel** than neutropenia.

Paclitaxel's ***, such as body aches, numbness at the ends of limbs, hair loss, etc. Body aches: This patient is in great pain, usually appearing 2-3 days after paclitaxel administration and lasting 3-5 days.

Numbness at the end of the limbs: This *** is caused by the toxicity of paclitaxel to nerve endings, which can be seen as neuritis**, and drugs that nourish nerves such as vitamin B can be used, but the effect is not very good, and there is no clinical data to support it. The pain of this kind of *** is relatively small and the patient can tolerate it.

Hair loss: Almost 70% of patients will lose their hair.

It is generally believed that the dose-limiting toxicity of paclitaxel is mainly neurotoxicity and bone marrow suppression, 6 cases in this group have muscle, joint pain or numbness, and its joint pain is mainly manifested in the lower limbs, after oral vitamins and symptomatic treatment, it disappears within about a week, and no sequelae are seen: 9 cases in this group, 7 cases have different degrees of bone marrow suppression, mainly ° suppression, and accompanied by slight cardiotoxicity (conduction block), which is consistent with the literature report 4. In addition, compared with other antineoplastic drugs, paclitaxel has fewer gastrointestinal reactions, and only 3 of the 9 patients we treated had gastrointestinal reactions, and 2 of them were combined cases, which further confirmed that the gastrointestinal reactions caused by purple were mild.

Paclitaxel is a drug widely used in cancer, and is often used in the following types of cancers

Breast Cancer:Paclitaxel is often used in combination with other chemotherapy drugs for both early and advanced breast cancer**.

Ovarian Cancer:Paclitaxel can be used in ovarian cancer** and can be used alone or in combination with other drugs.

Esophageal cancer:Paclitaxel is often used in combination with drugs such as cisplatin for advanced esophageal cancer.

Lung Cancer:Paclitaxel is often used in combination with drugs such as cisplatin or carboplatin for non-small cell lung cancer.

Pancreatic Cancer:Paclitaxel can be used in patients with advanced pancreatic cancer** and is often used in combination with other drugs.

In addition, paclitaxel can also be used for other types of cancer, including head and neck cancer, cervical cancer, colon cancer, stomach cancer, prostate cancer, etc. The specific mode of use and regimen should be determined by the doctor according to the patient's condition and needs. Patients in need can consult or purchase through formal overseas medical platforms (such as Hong Kong Maijikang Closed Xiaona Medical Center, etc.).

Please note that for specific cancer** regimens, other medications may also be used in combination with paclitaxel. If you or someone you know has been diagnosed with cancer, it is advisable to consult a medical professional for personalized** advice and protocols.

For nasopharyngeal carcinoma, carboplatin combined with paclitaxel induction chemotherapy and concurrent chemoradiotherapy with cisplatin **, nasopharyngeal carcinoma patients, induction chemotherapy effective primary lesion 16, regional lymph node 58, 2-year overall survival rate and progression-free survival rate were acceptable, respectively, and the patient tolerability was acceptable. Paclitaxel is still used more.

During chemotherapy, taking traditional Chinese medicine such as ginsenoside rh2 (life protectonin), cordyceps, etc. can reduce the production of chemotherapy drugs, improve the effect of chemotherapy, and prevent metastasis.

Three cycles of docetaxel (75 mg m2) and cisplatin (75 mg m2) chemotherapy were administered prior to radiotherapy, with an efficacy rate of 89 (37 complete responses). According to the results of the dose escalation clinical trial of the weekly use of Tysol chemotherapy for locally advanced nasopharyngeal carcinoma during the same period of radiotherapy, the recommended dose of Tysol was 30mg m2, and the main reaction was mucositis, ** reaction. In addition, as a first-line or second-line metastasis of nasopharyngeal carcinoma, Taxol monotherapy or combined platinum-based chemotherapy is effective.

Monotherapy is used in a 3-week regimen with a dose of 135 mg m2 and 175 mg m2 with an effective rate of 22 months and an effective duration of one month, and 60% with an effective rate of 72 in combination with carboplatin as a first-line median progression of 7 months. In another study, it was reported that with the support of growth factors with carboplatin (AUC per minute

7 mg ml) and Tysol 200 mg m2, with an effective rate of 57 months, the disease progression time was months, and the toxicity was significantly increased when the dose was further increased, while the efficacy was similar.

Paclitaxel is now the first-line drug for ovarian and breast cancers. It also has a certain effect on head and neck tumors and throat cancer. Drug resistance can develop with long-term use. Imported wild paclitaxel** is expensive. Domestic drugs are all artificially cultivated.