What causes motor neuron disease?

The current causes of MND are usually not a single factor, and multiple causes are considered, as follows:

1. Genetic background: At present, it has been found that about 10% of the pathogenic genes are clearly the pathogenic genes of motor neuron disease, and susceptibility factors have also been found, and there are hundreds of genes or mutation sites, which are easy to lead to the occurrence of motor neuron disease;

2. Aging: The incidence of motor neuron disease is less before the age of 50, the incidence is lower, and the incidence is high in the age group of 50-75 years. Apoptosis may be one of the causes as we age;

3. Environmental factors: such as lead poisoning, overwork, physical labor, and high-intensity exercise, may increase the incidence of motor neuron disease.

MND can manifest as weakness and atrophy of the limbs, clumsiness and weakness of finger movements, muscle weakness and atrophy over the course of the disease, extending to the trunk and neck, and finally involving the facial and throat muscles. Patients may have bulbar paralysis, mostly in the late stage, the tongue muscles are first involved, manifested as tongue muscle atrophy, fasciculation, and tongue protrusion weakness, followed by pharyngeal, laryngeal, and masticatory muscle atrophy and weakness, resulting in the patient's slurred arthria, dysphagia, chewing weakness, and the orbicularis oculi muscle in the facial muscle is more obviously involved. There is often a pattern of disease progression in MND, usually from the upper extremity that is first affected, then to the contralateral upper extremity, to the ipsilateral lower extremity, to the contralateral lower extremity, and finally to the bulb involvement.

Motor neuron disease can be life-threatening, mostly within 3 to 5 years, death from respiratory muscle paralysis or lung infection, so motor neuron disease is more harmful. You can come to Beijing Renxuan Traditional Chinese Medicine to find Sheng Jinqiangfu**, and through one-to-one conditioning of Yiyuan Muscle Formula, the patient's symptoms can be improved.

Motor neuron is also known as ALS, as the name of the disease suggests, patients will gradually appear as if they are "frozen", and the patient will gradually develop from limb weakness to muscle atrophy; The limbs gradually develop from the hands and feet, and eventually to the torso. Patients may experience dyspnea, dysphagia, and most eventually die of paralysis of the respiratory muscles. At present, Western medicine does not have a good method for motor neurons, but there is no way for motor neurons, and choosing the right professional method as soon as possible plays a vital role in motor neurons.

Motor neuron is an incurable disease, and the most important thing is to treat the symptoms**, so that it will slowly recover.

The ** of the MND is not clear. Since familial amyotrophic lateral sclerosis (ALS) and sporadic ALS have been observed to have strong overlap in phenotype, many scholars support the hand-like hypothesis that MND is caused by the exposure of genetically susceptible individuals to adverse environments.

There is some evidence to support the following mechanisms of acre skin as contributing factors to the pathophysiology of Mnd in Latent Diotics, including neurofilament structure and dysfunction, mitochondrial damage and dysfunction, glutamate excitotoxicity, oxidative damage secondary to free radical toxicity, and impaired neural regeneration secondary to microglial activation.

Middle-aged and elderly people may be affected by motor neuron disease in real life, and the occurrence of the disease will lead to the patient's behavior and activities being greatly limited, seriously affecting the quality of life of the patient, viral infection, inflammatory factors and metal element poisoning.

The occurrence of motor neuron disease, a chronic progressive neurodegenerative disease, can not ignore the damage caused to our health, although we can choose some scientific and reasonable ways to carry out motor neuron disease, but the related ** can not help us achieve the effect of complete motor neuron disease, so we must recognize the ** of motor neuron disease, and prevent the occurrence of the disease in time.

The occurrence of motor neuron disease is closely related to the following factors:

1. Viral infection is one of the leading causes of our health being damaged by motor neuron disease. Viruses such as enterovirus, poliovirus, and human immunodeficiency may directly invade our motor nervous system when they invade the human body, thus causing motor neuron disease.

2. The appearance of motor neuron disease may also be caused by inflammatory lesions. Our motor nerve companion system may be inflammatory due to the invasion, and the inflammatory factors caused by the rapid nucleation of inflammatory diseases are likely to damage our motor neurons through cascade reactions, resulting in our motor neuron death and disease damage.

3. Metal element poisoning is also a kind of motor neuron that causes the occurrence of **. The occurrence of mercury poisoning, lead poisoning and aluminum poisoning will cause patients to have some similar symptoms of motor neuron disease, so the occurrence of these metal poisoning and motor neuron disease have a certain relationship, and we must pay attention to prevent metal poisoning in practical life.

Relevant clinical studies show that middle-aged and elderly people are the main incidence groups of motor neuron disease, and the appearance of this disease will lead to muscle atrophy, muscle weakness, increased muscle tone, fasciculations and tendon hyperreflexia and other abnormal manifestations, timely and effective diagnosis and treatment can help us control the development of motor neuron disease and effectively improve our quality of life.

The exact nature and pathogenesis of motor neuron disease are unknown. It may cause the accumulation of toxic substances in the nervous system for various reasons, especially the increase of free radicals and excitatory amino acids, and damage nerve cells and cause disease.

First, the main **.

1. Genetic factors: most of the motor neuron disease is sporadic, a few have a family history, and the inheritance mode is mainly autosomal dominant. The most common causative gene is the copper (zinc) superoxide dismutase (SOD-1) gene on chromosome 21.

2. Infection and immunity: Some researchers believe that the onset of the disease may be related to poliovirus, enterovirus, and human immunodeficiency virus (HIV), and when the infection invades neurons, patients will have corresponding clinical manifestations.

3. Metallic elements: The onset of motor neuron disease may be related to certain metals, such as lead, mercury, aluminum, etc., and the difference in the content of metallic elements in the environment may also be the reason for the high incidence of geography in some regions.

4. Nutritional disorders: Some researchers have found that vitamin B1 and vitamin B1 monophosphate in the plasma of patients with amyotrophic lateral sclerosis (ALS) are reduced, which may lead to normal metabolic disorders of neurons, which in turn leads to amyotrophic lateral sclerosis.

5. Neurotransmitters: The level of inhibitory neurotransmitter GABA in the cerebrospinal fluid of ALS patients is significantly reduced, while norepinephrine is increased, and the more severe the disease, the more obvious this change is, and some studies have shown that the neurocytotoxic effect of excitatory amino acids (mainly glutamate and aspartic acid) plays an important role in the pathogenesis of ALS.

Motor neuron disease (MND) is a series of chronic progressive neurodegenerative diseases in which lower motor neuron damage is prominent.

There are a variety of hypotheses about the pathogenesis and pathogenesis of motor neuron disease, including genetic mechanisms, oxidative stress, excitotoxicity, neurotrophic factor disorders, autoimmune mechanisms, viral infections and environmental factors, etc., although the exact pathogenic mechanism is not yet known, but the current consensus is that oxidative damage and excitotoxicity on the basis of genetic background jointly damage motor neurons, mainly affecting the structure and function of mitochondria and cytoskeleton.

Some data show that older men, a history of trauma, and excessive physical exertion may be risk factors for the disease.

In addition, there may be factors such as immunity and infection, metallic elements, genetic factors, nutritional disorders, neurotransmitters.

In short, the pathogenesis of this disease is still unclear, and it may cause the accumulation of toxic substances in the nervous system due to various reasons, especially the increase of free radicals and excitatory amino acids, and damage nerve cells and cause disease.

Infection and immunity.

Some scholars believe that it may be related to prions and human immunodeficiency virus (HIV). Immunofunction assays have found that the number and function of T cells in the blood of patients with amyotrophic lateral sclerosis are abnormal, and immune complexes are formed, and it is speculated that the serum of patients may have a toxic effect on nerve blocks such as anterior horn cells.

Metal poisoning. Motor neuron disease may be associated with certain metal poisoning or deficiencies in certain elements. Studies have found that retrograde axonal flow of aluminum can cause anterior horn cell toxicity, leading to the development of disease.

Genetic factors. The disease is mostly sporadic, with 5% to 10% of patients having a family history, and the mode of inheritance is mainly autosomal dominant. The most common causative gene is the copper (zinc) superoxide dismutase gene. About 20% of familial and 2% of sporadic amyotrophic lateral sclerosis are associated with mutations in this gene.

Nutritional disorders. The study found that patients with amyotrophic lateral sclerosis had a decrease in both vitamin B and B monophosphate in their plasma. Motor neuron disease is mainly caused by genetic factors. One in 10 motor neuron cases is genetic, and adults are chromosomally dominant.

It may also be due to some immune factors, although serum tests in people with motor neuron disease show a lot of antibodies and immune complexes. However, immune factors are one of the typical factors that induce MND, and toxic factors are also strongly associated with MND. Viral infections, due to acute poliopathy, are predisposed to cause motor neuron disease.

Therefore, once the symptoms of motor neuron disease appear, it is necessary to go to a regular hospital for systematic examination as soon as possible, and then carry out symptomatic treatment after clarification.

Motor neuron disease is a neurodegenerative disease that primarily affects the motor system and not the sensory system. Motor neuron disease (MND) also invades upper and lower motor neurons, and often begins with weakness of the small muscles in one hand, accompanied by atrophy, and gradually progresses to other limbs, eventually affecting the respiratory and swallowing muscles, causing dyspnea and swallowing.

Motor neuron disease often progressively worsens, the course of the disease is about 3-5 years, you can come to Beijing Renxuan TCM to find Sheng Jinqiangfu**, through Yiyuan Muscle Formula one-to-one conditioning, can improve the patient's symptoms.

The human nervous system is composed of neurons, among which motor neurons are responsible for motor function. A group of diseases in which motor neurons are damaged and progress, known as motor neuron disease (MND), are known as motor neuron disease (MND).

Amyotrophic lateral sclerosis.

ALS, also known as ALS), progressive bulbar palsy, primary lateral sclerosis, and progressive amyotrophy.

Motor neuron degenerative disease is a chronic neurocannibalization disease, which is difficult to heal in the later stage of the disease, and when the disease is severe, it can invade the anterior horn cells of the spinal cord and the nerve nucleus of the brainstem and the pyramidal cells of the motor cortex of the brain, resulting in dyspnea, dysphagia and life-threatening, about 5%-7% of patients are caused by abnormal genetic immunity or viral infection. The remaining patients** are unknown, but have been reported to be related to heavy metals, chemical poisoning, and the surrounding environment.

Motor neurons are neurons that are responsible for transmitting messages from the spinal cord and brain to the muscles and endocrine glands that innervate organ activity. Motor neuron disease (MND) is a rare disease that is a series of chronic progressive neurodegenerative diseases characterized by motor neuron changes. At present, the cause of the disease is not clear, and patients present with muscle weakness, muscle atrophy, bulbar paralysis, etc., and usually have no paresthesias.

The disease mostly occurs in middle-aged and elderly people, and the course of the disease is mostly 2 to 6 years, and most of them have a poor prognosis, and often die of respiratory muscle paralysis or lung infection due to respiratory muscle involvement.

There is still a lack of drugs that can effectively reverse or control the progression of the disease. The motor neuron disease pathogen is diverse and affects each other, so it must be a combination of multiple methods. The ** of motor neuron disease includes **, symptomatic ** and various non-pharmacos**.

At present, there is no specific diet to avoid for MND, and a balanced diet is sufficient.

The nursing of patients with motor neuron disease should always pay attention to the nutritional status, swallowing function and respiratory status of the patients, care about the psychological status of the patients, keep the environment clean and tidy, and reduce the occurrence of complications.

Take the drug according to the doctor's instructions, understand the possible adverse reactions of the drug, and regularly review the blood routine and liver and kidney function during the medication.

Depending on their condition, patients should do some appropriate exercises under the guidance of a doctor.

For patients who have been bedridden for a long time, the surrounding environment should be kept clean and tidy, and family members or nursing staff should help patients turn over, pat their backs, massage, and scrub on time every day to reduce the occurrence of complications such as infections and bedsores.

Patients with dysphagia should slow down their eating and try to avoid aspiration.

What causes MND? Write.

774 Causes of motor neuron disease: 1. Immune factors, although a variety of antibodies and immune complexes have been detected in the serum of patients with motor neuron disease, there is no evidence that these antibodies do not selectively target motor neuron cells, and immune factors are one of the typical factors that induce motor neuron disease. Second, genetic factors, 10% of the causes of motor neurons are hereditary, called familial amyotrophic lateral sclerosis, adult form is autosomal dominant inheritance, young form is normal color dominant or recessive inheritance.

Third, the cause of poisoning, the cause of motor neurons has a significant relationship with poisoning. Fourth, viral infection, because both MND and acute polio invade motor neurons in the anterior horn of the spinal cord and a small number of polio, MND occurs later in patients with disease, so it is speculated that the ** of motor neurons is related to poliovirus-like postoperative infection.