What is the muscle atrophy cycle of motor neurons?

Motor neuron disease is also divided into many types, each type of survival cycle is still different, if it is a type of amyotrophic lateral sclerosis, patients will have upper motor neuron and lower motor neuron damage at the same time, the survival cycle is generally 3 to 5 years, generally due to lung infection and respiratory failure and death, if it is progressive bulbar palsy, the disease progresses faster, the survival cycle is about 1 to 2 years.

If it is primary lateral sclerosis, this disease is relatively rare, the patient progresses slowly, can survive for a long time, if it is progressive amyotrophy, the survival cycle can reach more than 10 years or longer, of course, the survival cycle and the patient's care, nutritional status are obviously related.

The survival time of neurogenic muscular atrophy varies depending on the damaged part of neurogenic muscular atrophy.

If the anterior horn cells of the spinal cord are damaged, such as acute polio, that is, polio, which does not affect the life expectancy, if the muscle atrophy caused by the damage of the anterior horn cells of the spinal cord caused by motor neuron disease such as ALS, the prognosis of the patient is relatively poor, and the general patient has a continuous progression, and the paralysis of the respiratory muscles or lung infection leads to death within five years. If muscle atrophy occurs due to nerve root or nerve trunk damage, it is most common in cervical spondylosis, lumbosacral trauma, and lumbar spondylosis, often affecting lifespan. Muscle atrophy due to damage to the plexus, common in brachial plexitis, lumbosacral plexopathy, and traumatic tumors, does not affect lifespan.

Muscle atrophy caused by peripheral nerve damage due to various causes causes atrophy of muscles in a localized mononeurvular distribution and generally does not affect lifespan. Common traumatic and grounded mononeuropathy, as well as infectious metabolic toxicity, polyneuropathy, and hereditary metabolic neuropathy such as peroneal muscular atrophy and porphyria, do not affect the life expectancy of patients.

Patients with neurogenic muscular atrophy need a high-protein, high-energy diet to provide the necessary substances for the reconstruction of nerve cells and skeletal muscle cells, mainly semi-liquid and liquid food, and adopt small and frequent meals to maintain the patient's nutrition, water and electrolyte balance.

Muscle atrophy, usually more severe. Muscular atrophy is most commonly seen in motor neuron disease, peripheral neuropathy, and myopathy, among others, as follows:

1. The most common type of motor neuron disease is amyotrophic lateral sclerosis, which occurs at an age of 30-60 years old, and is more common in men than in women, showing typical clinical features of simultaneous damage of upper and lower motor neurons. Patients may have muscle atrophy, accompanied by fasciculations, and the progression of the disease can usually involve respiratory muscles, swallowing muscles, etc., and the prognosis of patients is mostly poor, and most of them die of respiratory muscle paralysis within 3-5 years.

2. Peripheral nerve diseases, such as Guillain-Barré syndrome, can also cause muscle atrophy, which is difficult to improve.

3. Some myopathies, such as muscular dystrophy, can also cause muscle atrophy and the prognosis is not good.

Lower motor neuron damage syndrome is a condition in which paralyzed muscles are limited to a few muscles, and paralysis of a certain movement is the main manifestation, such as the inability to extend the dorsum of the wrist; The muscle tone of the paralyzed muscles is significantly reduced, and the paralysis is flaccid; loss of tendon reflexes of paralyzed muscles; There is significant amyotrophy; There is no pyramidal tract sign.