Why is cancer genetically determined?

Cancer is the most common genetic disease, and when all cancers appear, they will be abnormalities in the DNA sequence, because different cancers have different causes and symptoms, but most cancers can be explained by genetic mutations, so there is a certain relationship between cancer and genes.

Because many cancers are hereditary, if parents carry a certain disease, they will pass on the genes that carry the disease to their children, so that children may have sudden outbreaks of disease when they grow up.

This is because some cancers are hereditary, so cancer and genes are also related, and if there is a gene lesion or cancer cells, cancer will occur.

Because cancer is formed by genetic mutations, this is why there is such an idea. In our daily life, we must have correct eating habits and living habits.

Because there are some genes that cause cells to be more prone to cancer, there is such a statement, and it is indeed related to genes.

Some cancers have a clear genetic predisposition, which means that if someone in the family has these cancers, then the risk of other family members will also be greatly increased. Here are some of the cancers that may be inherited and passed on to the next generation:

Breast cancer: If there is a patient with breast cancer in the family, then the probability of developing breast cancer increases significantly.

Ovarian cancer: In some families, ovarian cancer often occurs at the same time as breast cancer because the two are genetically similar. If someone in the family has ovarian cancer, then the risk of ovarian cancer also increases.

Colorectal cancer: Colorectal cancer is a relatively common genetic cancer. If there are more than one family member with colorectal cancer, then the risk of developing this cancer will be greatly increased.

Stomach cancer: If someone in the family has stomach cancer, then there is also an increased risk of stomach cancer.

Overall, cancer is a very complex disease, and its pathogenesis involves several factors, of which genetic factors are only some of the many factors. Genetic predisposition does not mean that you will have the disease, but paying attention to the influence of genetic factors on the occurrence of cancer can help you avoid risk factors and take effective preventive measures. If there is a family member with cancer, regular check-ups should be done to detect the cancer as early as possible.

In addition, a healthy lifestyle such as eating a sensible diet, exercising in a hinge province, quitting smoking and limiting alcohol, reducing stress and environmental pollution can also help reduce the risk of cancer.

Carcinoma is caused by mutations in oncogenes. The causes of oncogene mutations can be divided into two categories: one is caused by acquired natural aging, lifestyle and environmental factors, such as smoking, drinking, radiation, etc.; The other is caused by a congenital inheritance of a certain oncogene mutation.

Some types of cancer are hereditary because some oncogenes mutate. However, most cancers are caused by acquired factors and are not passed on to the next generation. About 5%-10% of cancers are directly caused by inherited genetic mutations, and it is very likely that they will be passed on to the next generation.

Inherited gene mutations can increase the risk of many types of cancer, so it's important to know your family history of cancer. If there is a lack of grandchildren in the family and patients with bowel cancer, it should be noted that routine physical examinations should be performed. Colonoscopy is recommended after the age of 40 and if there are no abnormalities, the colonoscopy should be repeated at least every 5 years.

Familial breast and ovarian cancer syndrome: caused by mutations in the BRCA1 and BRCA2 genes, inherited in an autosomal dominant manner. The risk of this genetic cancer is high, with a high risk of breast cancer and ovarian cancer of up to 60%-80% and 30%-40% in women.

Hereditary colorectal cancer: caused by a variety of genetic mutations, the most common of which is the APC gene mutation. The risk of this genetic cancer is high, with patients having a 70%-80% risk of colorectal and rectal cancer.

Hereditary gastric cancer: caused by mutations in the CDH1 gene, inherited in an autosomal dominant manner. The risk of this genetic cancer is high, with a risk of up to 70%-80% for patients developing stomach cancer.

Neurofibromatosis type 1: caused by mutations in the NF1 gene and inherited in an autosomal dominant manner. The risk of this genetic cancer is high, with a risk of up to 50% for neurofibromas and other types of tumors with bridges.

Hereditary breast cancer: caused by mutations in multiple genes, such as the Chek2 and ATM genes, and is inherited in an autosomal dominant manner. The risk of this genetic cancer is higher, with patients having up to 40% of the risk of developing breast cancer.

These cancers may be passed on to the next generation, but not every genetic mutation causes cancer. As in the case of hereditary cancer, genetic cancer is not the only risk factor for cancer, but also factors such as environment and lifestyle may also play a role in cancer risk.

Carcinogenesis should occur only when both proto-oncogenes and tumor suppressor genes are mutated, which can also explain why cancer always occurs in people of a certain age, because the probability of all these mutations is low, so it takes a long time. However, cancer has congenital sensitivities, such as congenital defects in proto-oncogenes or tumor suppressor genes, which are more likely to become cancerous, so they will show a certain familial genetic tendency

Activation of proto-oncogenes is the root cause, but if the mutation of the tumor suppressor gene is inactive, its function is weakened, and the cells will replicate repeatedly in an uncontrolled state, eventually forming tumors and metastasizing